Modulated expression of genes associated with NO signal transduction contributes to the cholesterol-lowering effect of electro-acupuncture

Li, Ling; Tan, Guangming; Zhang, Yizheng

doi:10.1007/s10529-012-0892-9

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…We suspected IMT assesses structural changes, so IMT changes appears more inconspicuous than PWV improvement. Lipid levels are also necessary to achieve ideal cardiovascular health [32] , and previous study indicated that electroacupuncture at ST40 can lower the levels of serum cholesterol and triacylglycerols [33] , so we selected Lipid levels as secondary outcomes. Despite the results show no changes in lipid levels, we speculated this might be associated with different acupoints selection or bias caused by diary.…”

Section: Discussionmentioning

confidence: 99%

Effect of Acupuncture on Artery Elasticity for Atherosclerosis: A Randomized Controlled Trial

Zhao

Zhang

et al. 2022

Preprint

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Background Atherosclerosis (AS) is a chronic arterial disease. Atherosclerosis related diseases, like myocardial infarctions (MI) and strokes have the highest mortality and disability rate. However, limited evidence verified the effects of acupuncture on arterial stiffness for subclinical atherosclerosis. We hypothesized that acupuncture could improve arterial stiffness in subclinical atherosclerosis and resist plaque progression. The aim of this study is to assess the effect of acupuncture on arterial elasticity via ultrafast pulse wave velocity (ufPWV) and explore the effect of acupuncture on lipid level and platelet function for subclinical atherosclerosis patients.MethodsThis was a randomized parallel controlled trial included 44 patients. Patients were assigned in a 1:1 ratio to acupuncture group and sham acupuncture group. Patients completed 24 treatments in total within 12 weeks of intervention. The primary outcome was ultrafast pulse wave velocity (ufPWV) assessed after every 4-weeks treatment; the secondary outcomes were carotid intima-media thickness (cIMT), blood lipid levels, fibrinogen (FIB) and blood platelet. Intention-to-treat (ITT) principle was applied and data sets were analyzed using SPSS 20.0 software.ResultsAmong the 44 randomly assigned patients, changes of right-side BS value in TA group (0.841) at week 12 were greater than SA group (-0.189), with a mean difference of 1.030 (95% CI, 0.320, 1.739; P=0.006). Similar results were observed in right-side ES, left-side BS, left-side ES at week 12. As to secondary outcomes, compared with SA group(1.08mm), the TA group(0.98mm) showed a significant decline in mean of left-side IMT at week 12. (Z= -2.118; P=0.034). There were no serious adverse events.ConclusionsAmong patients with Carotid intima-media thickening, both-side carotids arterial elasticity is significantly improved after 12-week acupuncture compared with sham acupuncture. The effects of acupuncture are more noticeable at week 12 during end-systole.Trial registrationThe trial was registered at http://www.chictr.org.cn (NO. ChiCTR1900025551, 31/08/2019)

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Section: Discussionmentioning

confidence: 99%

Effect of Acupuncture on Artery Elasticity for Atherosclerosis: A Randomized Controlled Trial

Zhao

Zhang

et al. 2022

Preprint

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“…Hyperglycemia and oxidative damage were relieved after preventive acupuncture by reducing LPO level and enhancing SOD activity in the serum and the pancreas of streptozotocin-induced hyperglycemia rats [74]. More studies confirmed that EA exerts its antioxidative effect through inducing nNOS and iNOS expressions which are involved in NO signal transduction and increasing total NO concentration in hypercholesterolemia rats [75], acetylsalicylic acid-induced acute gastritis rats [76], and LPS-induced kidney injury rats [77]. …”

Section: Other Diseasesmentioning

confidence: 99%

Acupuncture Mechanism and Redox Equilibrium

Zeng

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Oxidative stress participates in the pathological process of various diseases. Acupuncture is a component of the health care system in China that can be traced back for at least 3000 years. Recently, increased evidences indicate that acupuncture stimulation could reduce oxidative damage in organisms under pathological state, but the exact mechanism remains unclear. This review focuses on the emerging links between acupuncture and redox modulation in various disorders, such as vascular dementia, Parkinson's disease, and hypertension, ranging from redox system, antioxidant system, anti-inflammatory system, and nervous system to signaling pathway. Although the molecular and cellular pathways studies of acupuncture effect on oxidative stress are preliminary, they represent an important step forward in the research of acupuncture antioxidative effect.

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“…as to promote reverse cholesterol transport [17]. Furthermore, real-time PCR and western blot indicate that electroacupuncture at ST 40 induces the expression of nNOS and Mt1, two genes involved in NO signal transduction [18]. Acupuncture treatment for hypercholesterolemia thus involves the modulation of several biological pathways and provides a physiological link between NO signal transduction and the cholesterol-lowering effect of acupuncture [18].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture in Cardiology

Cheng¹

2013

Acupuncture in Modern Medicine

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Modulated expression of genes associated with NO signal transduction contributes to the cholesterol-lowering effect of electro-acupuncture

Cited by 8 publications

References 23 publications

Effect of Acupuncture on Artery Elasticity for Atherosclerosis: A Randomized Controlled Trial

Effect of Acupuncture on Artery Elasticity for Atherosclerosis: A Randomized Controlled Trial

Acupuncture Mechanism and Redox Equilibrium

Acupuncture in Cardiology

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