Modularly engineered alginate bioconjugate hydrogel as biocompatible injectable scaffold for in situ biomineralization

Kim, Seong Han; Thambi, Thavasyappan; Phan, Vu To-Anh; Lee, Sang Soo

doi:10.1016/j.carbpol.2020.115832

Cited by 50 publications

(37 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example post modification of alginate by conjugating temperature-responsive poly (ε-caprolactone-co-lactide)-b-poly(ethylene glycol)b-poly(ε-caprolactone-co-lactide) and Ophosphorylethanolamine as phosphorylation functional groups resulted temperature responsivity. 182 Again, glycidyl methacrylate-modified hydroxypropyl chitin was transformed to photo crosslinkable hydrogel with reversible thermoresponsive property even at low concentration (2 wt% in PBS). 183 A series of novel thermosensitive hydrogels containing chitosan (CS) and acid-soluble collagen (ASC) were demonstrated in the presence of α, β-glycerophosphate.…”

Section: Temperature Sensitivitymentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

View full text Add to dashboard Cite

Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

show abstract

Section: Temperature Sensitivitymentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Alginate scaffolds possess bone regeneration properties (Hwang et al, 2009;Kim et al, 2020), as embryonic stem cells encapsulated in alginate hydrogels cultured in a microgravity bioreactor, showed enhanced differentiation and osteogenesis (Hwang et al, 2009). HA mixed with alginate increased its mechanical strength, and the resulting scaffold possessed excellent osteogenic effects (Venkatesan et al, 2015).…”

Section: Alginate: a Marine Anionic Biopolymer From Brown Seaweeds Fomentioning

confidence: 99%

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

Zhang

Zhao

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bone is a dynamic organ with high regenerative potential and provides essential biological functions in the body, such as providing body mobility and protection of internal organs, regulating hematopoietic cell homeostasis, and serving as important mineral reservoir. Bone defects, which can be caused by trauma, cancer and bone disorders, pose formidable public health burdens. Even though autologous bone grafts, allografts, or xenografts have been used clinically, repairing large bone defects remains as a significant clinical challenge. Bone tissue engineering (BTE) emerged as a promising solution to overcome the limitations of autografts and allografts. Ideal bone tissue engineering is to induce bone regeneration through the synergistic integration of biomaterial scaffolds, bone progenitor cells, and bone-forming factors. Successful stem cell-based BTE requires a combination of abundant mesenchymal progenitors with osteogenic potential, suitable biofactors to drive osteogenic differentiation, and cell-friendly scaffold biomaterials. Thus, the crux of BTE lies within the use of cell-friendly biomaterials as scaffolds to overcome extensive bone defects. In this review, we focus on the biocompatibility and cell-friendly features of commonly used scaffold materials, including inorganic compound-based ceramics, natural polymers, synthetic polymers, decellularized extracellular matrix, and in many cases, composite scaffolds using the above existing biomaterials. It is conceivable that combinations of bioactive materials, progenitor cells, growth factors, functionalization techniques, and biomimetic scaffold designs, along with 3D bioprinting technology, will unleash a new era of complex BTE scaffolds tailored to patient-specific applications.

show abstract

“…Later on, hydrogel became a hotspot research subject for biomaterial scientists, where then numerous natural, synthetic and hybrid polymer hydrogels were extensively synthesized and studied [ 4 ]. The sol–gel phase transition properties, mucoadhesiveness and biodegradation through physiological stimuli (pH, enzyme and temperature) of these polymeric materials revolutionized the whole field because they were non-invasive therapeutic agents that provided a controlled/sustained delivery depot at the site of interest [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

et al. 2022

View full text Add to dashboard Cite

Injectable hydrogels (IHs) are smart biomaterials and are the most widely investigated and versatile technologies, which can be either implanted or inserted into living bodies with minimal invasion. Their unique features, tunable structure and stimuli-responsive biodegradation properties make these IHs promising in many biomedical applications, including tissue engineering, regenerative medicines, implants, drug/protein/gene delivery, cancer treatment, aesthetic corrections and spinal fusions. In this review, we comprehensively analyze the current development of several important types of IHs, including all those that have received FDA approval, are under clinical trials or are available commercially on the market. We also analyze the structural chemistry, synthesis, bonding, chemical/physical crosslinking and responsive release in association with current prospective research. Finally, we also review IHs’ associated future prospects, hurdles, limitations and challenges in their development, fabrication, synthesis, in situ applications and regulatory affairs.

show abstract

Modularly engineered alginate bioconjugate hydrogel as biocompatible injectable scaffold for in situ biomineralization

Cited by 50 publications

References 49 publications

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

Contact Info

Product

Resources

About