Modular micropumps fabricated by 3D printed technologies for polymeric microfluidic device applications

Alvarez-Braña, Yara; Etxebarria-Elezgarai, Jaione; Larrinaga-Vicente, L. Ruiz de; Benito‐Lopez, Fernando; Basabe‐Desmonts, Lourdes

doi:10.1016/j.snb.2021.129991

Cited by 21 publications

(10 citation statements)

References 37 publications

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“…We also show that the “T-shaped” microstructures can prevent the wetting of human plasma (Figure S4 in the Supporting Information), which is a huge advantage of reducing biofouling issues for in vivo applications . In the future, microvalves, micropumps, and LED light sources can also be 3-D printed and integrated with our optofluidics system as a single unit for sample loading, sensing, and treatment. , …”

Section: Resultsmentioning

confidence: 82%

“…36 In the future, microvalves, micropumps, and LED light sources can also be 3-D printed and integrated with our optofluidics system as a single unit for sample loading, sensing, and treatment. 37,38 ■ CONCLUSIONS In summary, different designed geometries of superhydrophobic-based optofluidic devices were built by high-resolution stereolithography techniques and examined via transmission and fluorescence measurements. The solid fraction within the range of theoretically required cladding thickness and the smoothness of the core's cross-section were investigated to optimize our fully enclosed optofluidic devices.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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On-Demand Fully Enclosed Superhydrophobic–Optofluidic Devices Enabled by Microstereolithography

et al. 2022

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Superhydrophobic surface-based optofluidics have been introduced to biosensors and unconventional optics with unique advantages, such as low light loss and power consumption. However, most of these platforms were made with planar-like microstructures and nanostructures, which may cause bonding issues and result in significant waveguide loss. Here, we introduce a fully enclosed superhydrophobic-based optofluidics system, enabled by a one-step microstereolithography procedure. Various microstructured cladding designs with a feature size down to 100 μm were studied and a "T-type" overhang design exhibits the lowest optical loss, regardless of the excitation wavelength. Surprisingly, the optical loss of superhydrophobic-based optofluidics is not solely decided by the solid area fraction at the solid/water/air interface, but also the cross-section shape and the effective cladding layer composition. We show that this fully enclosed optofluidic system can be used for CRISPR-labeled quantum dot quantification, intended for in vitro and in vivo CRISPR therapeutics.

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Section: Resultsmentioning

confidence: 82%

Section: ■ Results and Discussionmentioning

confidence: 99%

On-Demand Fully Enclosed Superhydrophobic–Optofluidic Devices Enabled by Microstereolithography

et al. 2022

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“…Leveraging the high resolution of stereolithography, the "T-shape" structures can be fabricated with a smaller dimension for microsurgery while still providing efficient light transmission 30 . In the future, microvalves, micropumps, and LED light sources can also be 3-D printed and integrated with our optofluidics system as a single unit for sample loading, sensing, and treatment 31,32 . Negative control (without target) is labeled as NTC.…”

Section: Resultsmentioning

confidence: 99%

On-Demand Fully-Enclosed Superhydrophobic-Optofluidic Device Enabled by High Precision Microstereolithography

Chang

Bao

Waitkus

et al. 2022

Preprint

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Superhydrophobic surface-based optofluidics have been introduced to biosensors and unconventional optics with unique advantages such as low light loss and power consumption. However, most of these platforms were made with planar-like micro- and nano-structures, which may cause bonding issues and resulting in significant waveguide loss. Here, we introduce a fully-enclosed superhydrophobic-based optofluidics system, enabled by a one-step high precision microstereolithography procedure. Various micro-structured cladding designs with a feature size down to 100 μm were studied and a “T-type” overhang design exhibits the lowest optical loss, regardless of the excitation wavelength. Surprisingly, the optical loss of superhydrophobic-based optofluidics is not solely decided by the solid area fraction at the solid/water/air interface, but also the cross-section shape and the effective cladding layer composition. We show that this fully-enclosed optofluidic system can be used for CRISPR-labeled quantum dot quantification, intended for in vitro and in vivo CRISPR therapeutics.

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“…To avoid channel clogging and improve the device fabrication throughput, the community of 3D printed microfluidics has been actively studying an additive alternative that makes devices from separately printed components, which simplifies the postprocessing and circumvents the structural degradation during complex material removal. This modularized approach employs a "LEGO®-like" method for device construction and is capable of multiple printing modalities, realizing a wide range of functionalities such as autonomous components, 89,90 logic circuitry components, 91 spatial microfluidic networks, 92,93 organs-on-a-chip, 94,95 and sensors, 96 etc.…”

Section: Modularized Integration Of 3d Printed Microfluidic Devicesmentioning

confidence: 99%

3D printed microfluidics: advances in strategies, integration, and applications

Wang

McAlpine

2023

Lab Chip

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Modular micropumps fabricated by 3D printed technologies for polymeric microfluidic device applications

Cited by 21 publications

References 37 publications

On-Demand Fully Enclosed Superhydrophobic–Optofluidic Devices Enabled by Microstereolithography

On-Demand Fully Enclosed Superhydrophobic–Optofluidic Devices Enabled by Microstereolithography

On-Demand Fully-Enclosed Superhydrophobic-Optofluidic Device Enabled by High Precision Microstereolithography

3D printed microfluidics: advances in strategies, integration, and applications

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