Modular microfluidic interconnects using photodefinable silicone microgaskets and MEMS O-rings

Miserendino, Scott; Tai, Yu‐Chong

doi:10.1016/j.sna.2007.07.019

Cited by 19 publications

(10 citation statements)

References 7 publications

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“…In general, two modular microfluidic design strategies have been proposed previously: systems analogous to electronic breadboards (6, 7) and interconnected monolithic chips (8)(9)(10). Burns and coworkers demonstrated a variation to breadboard-style systems by fabricating planar microfluidic puzzle pieces with self-aligning channels (11,12).…”

mentioning

confidence: 99%

Discrete elements for 3D microfluidics

Bhargava¹,

Thompson

Malmstadt³

2014

Proc. Natl. Acad. Sci. U.S.A.

260

226

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Microfluidic systems are rapidly becoming commonplace tools for high-precision materials synthesis, biochemical sample preparation, and biophysical analysis. Typically, microfluidic systems are constructed in monolithic form by means of microfabrication and, increasingly, by additive techniques. These methods restrict the design and assembly of truly complex systems by placing unnecessary emphasis on complete functional integration of operational elements in a planar environment. Here, we present a solution based on discrete elements that liberates designers to build large-scale microfluidic systems in three dimensions that are modular, diverse, and predictable by simple network analysis techniques. We develop a sample library of standardized components and connectors manufactured using stereolithography. We predict and validate the flow characteristics of these individual components to design and construct a tunable concentration gradient generator with a scalable number of parallel outputs. We show that these systems are rapidly reconfigurable by constructing three variations of a device for generating monodisperse microdroplets in two distinct size regimes and in a high-throughput mode by simple replacement of emulsifier subcircuits. Finally, we demonstrate the capability for active process monitoring by constructing an optical sensing element for detecting water droplets in a fluorocarbon stream and quantifying their size and frequency. By moving away from large-scale integration toward standardized discrete elements, we demonstrate the potential to reduce the practice of designing and assembling complex 3D microfluidic circuits to a methodology comparable to that found in the electronics industry. modular microfluidics | microfluidic circuit design | 3D-printed microfluidics

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mentioning

confidence: 99%

Discrete elements for 3D microfluidics

Bhargava¹,

Thompson

Malmstadt³

2014

Proc. Natl. Acad. Sci. U.S.A.

260

226

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“…Stereo lithography 3D printing was used to fabricate the blocks for this system, which were interconnected using mini-Luer connections. Miserendino [23] showed a system used a clamping to seal, with patternable silicone micro gaskets between the baseplate and functional blocks.…”

Section: Introductionmentioning

confidence: 99%

Standardized and modular microfluidic platform for fast Lab on Chip system development

Dekker

Buesink

Blom

et al. 2018

Sensors and Actuators B: Chemical

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a b s t r a c tSince the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.

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“…To overcome these issues, they proposed non planar (3D) modular systems. In addition a number of researchers underline the movement of microfluidics towards modularity (Castellino, 2004, Fitzgerald, 2003, Gilde et al 2005, Grodzinski et al 2003, Grodzinski et al 2004, Miserendino, 2007, Miserendino and Tai, 2008.…”

Section: Introductionmentioning

confidence: 99%

Design practices used in the development of microfluidic devices: a services-based view

Panikowska

Tiwari

Alcock

et al. 2016

IJMTM

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This paper presents the current state of microfluidic design from a practitioner's perspective. The capture of microfluidic design practice was facilitated through a combination of industry survey and expert interviews, allowing the authors to draw out models for microfluidic design. Exploration of the current practice of microfluidic design showed that formal design methodologies were not in use. This research has also found that subsection interactions have been addressed in an inadequate fashion by current design practices. The work presented in this paper outlines the scope for further research in the development of a formal design methodology for microfluidics.

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Modular microfluidic interconnects using photodefinable silicone microgaskets and MEMS O-rings

Cited by 19 publications

References 7 publications

Discrete elements for 3D microfluidics

Discrete elements for 3D microfluidics

Standardized and modular microfluidic platform for fast Lab on Chip system development

Design practices used in the development of microfluidic devices: a services-based view

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