Modular design of multifunctional core-shell tecto dendrimers complexed with copper(II) for MR imaging-guided chemodynamic therapy of orthotopic glioma

Song, Cong; Ouyang, Zhijun; Gao, Yue; Guo, Huibin; Wang, Shunjuan; Wang, Dayuan; Xia, Jindong; Shen, Mingwu; Shi, Xiangyang

doi:10.1016/j.nantod.2021.101325

Cited by 27 publications

(25 citation statements)

References 56 publications

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Section: Cu‐based Nms For Cancer Monotherapymentioning

confidence: 99%

“…Herein, based on the recognition between β‐cyclodextrin (CD) and adamantane (Ad), supramolecular assembled tectodendrimers with acetyl termini (M‐CSTD. NHAc) were prepared for glioma theranostics (Figure 7d; Song et al, 2021). In this core–shell structure, the core of CSTDs was composed of CD‐modified generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers and Ad‐functionalized G3 PAMAM dendrimers (G3.…”

Section: Cu‐based Nms For Cancer Monotherapymentioning

confidence: 99%

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Copper‐based nanomaterials for cancer theranostics

Zhong

Wang

Qian

et al. 2022

WIREs Nanomed Nanobiotechnol

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Copper‐based nanomaterials (Cu‐based NMs) with favorable biocompatibility and unique properties have attracted the attention of many biomedical researchers. Cu‐based NMs are one of the most widely studied materials in cancer treatment. In recent years, great progress has been made in the field of biomedicine, especially in the treatment and diagnosis of tumors. This review begins with the classification of Cu‐based NMs and the recent synthetic strategies of Cu‐based NMs. Then, according to the abundant and special properties of Cu‐based NMs, their application in biomedicine is summarized in detail. For biomedical imaging, such as photoacoustic imaging, positron emission tomography imaging, and multimodal imaging based on Cu‐based NMs are summarized, as well as strategies to improve the diagnostic effectiveness. Moreover, a series of unique structures and functions as well as the underlying property activity relationship of Cu‐based NMs were shown to highlight their promising therapeutic performance. Cu‐based NMs have been widely used in monotherapies, such as photothermal therapy (PTT) and chemodynamic therapy (CDT). Moreover, the sophisticated design in composition, structure, and surface fabrication of Cu‐based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. To further improve the efficiency of cancer treatment, combined therapy based on Cu‐based NMs was introduced in detail. Finally, the challenges, critical factors, and future prospects for the clinical translation of Cu‐based NMs as multifunctional theranostic agents were also considered and discussed. The aim of this review is to provide a better understanding and key consideration for the rational design of this increasingly important new paradigm of Cu‐based NMs as theranostic agents. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

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Section: Cu‐based Nms For Cancer Monotherapymentioning

confidence: 99%

Section: Cu‐based Nms For Cancer Monotherapymentioning

confidence: 99%

Copper‐based nanomaterials for cancer theranostics

Zhong

Wang

Qian

et al. 2022

WIREs Nanomed Nanobiotechnol

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“…These contrast agents are summarized mainly from the following perspectives, including the constituent materials, targeting moieties, tumor models and imaging modalities (Table 1). Fe 3 O 4 @Au-C225 C225 Subcutaneous U251 mice model MRI(T2) [87] Gd-DTPA-DGLs-PEG-CTX CTX Orthotopic C6 mice model MRI(T1) [88] DPC-DTPA-Gd CD Orthotopic U87MG mice model MRI(T1) [42] Gd-NGO/Let-7 g/EPI -Orthotopic U87MG mice model MRI(T1) [89] Au@DTDTPA-Gd -Orthotopic 9LGS mice model MRI(T1) [90] Gd 3 N@C 80 (OH) x (NH 2 ) y ((amino-1)) Interleukin-13 Orthotopic U251 mice model MRI(T1) [91] iRPPA@TMZ/MnO iRGD Orthotopic C6 mice model MRI(T1) [92] Den-RGD-Reg + Gd 3+ -DTPA RGD and Regadenoson Orthotopic U87MG mice model MRI(T1) [93] NaGdF4-TAT-labeled T cell T cell Orthotopic GL261 mice model MRI(T1) [94] HA-MnO 2 HA Orthotopic C6 mice model MRI(T1) [95] CPP-2 Ang Orthotopic C6 mice model MRI(T1) [96] MnO 2 @Tf-ppIX Tf Orthotopic C6 mice model MRI(T1) [37] AGuIX@PS@KDKPPR KDKPPR Orthotopic U87MG mice model MRI(T1) [97] Fe 3 O 4 -ANG ANG Orthotopic U87L mice model MRI(T1) [98] M-CSTD.NHAC/Cu(II) RGD and DER Orthotopic C6 mice model MRI(T1) [99] Pt/MnO 2 @PVCL NGs Macrophage membrane Orthotopic C6 mice model MRI(T1) [56] HB-POEGMA-cRGD-Gd cRGD Subcutaneous U87MG mice model MRI(T1) [100] rUCNPs@HSA(Ce6-Mn)-RGD RGD Subcutaneous U87MG mice model MRI(T1) [101] Mn-ZIF-…”

Section: Contrast Agents For Mri and Multimodal Imaging Modalitiesmentioning

confidence: 99%

“…Notably, Cu ions would greatly contribute to intratumoral Fentonlike catalyzation process with generation of large amount of reactive oxygen species for killing tumor cells [181]. Recently, a multifunctional core-shell tecto dendrimers with acetyl termini (M-CSTD.NHAc) was proposed to chelate Cu 2+ for theranostics of orthotopic glioma [99]. Briefly, β-cyclodextrin (CD)-modified G5 PAMAM dendrimers were selected as cores and adamantane (Ad)functionalized G3 PAMAM dendrimers (G3.…”

Section: Cu-based Npsmentioning

confidence: 99%

Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Zhuang

Zhang

2022

J Nanobiotechnol

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Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high incidence and degree of malignancy as well as poor prognosis. Due to the existence of formidable blood–brain barrier (BBB) and the aggressive growth and infiltrating nature of GBM, timely diagnosis and treatment of GBM is still very challenging. Among different imaging modalities, magnetic resonance imaging (MRI) with merits including high soft tissue resolution, non-invasiveness and non-limited penetration depth has become the preferred tool for GBM diagnosis. Furthermore, multimodal imaging with combination of MRI and other imaging modalities would not only synergistically integrate the pros, but also overcome the certain limitation in each imaging modality, offering more accurate morphological and pathophysiological information of brain tumors. Since contrast agents contribute to amplify imaging signal output for unambiguous pin-pointing of tumors, tremendous efforts have been devoted to advances of contrast agents for MRI and multimodal imaging. Herein, we put special focus on summary of the most recent advances of not only MRI contrast agents including iron oxide-, manganese (Mn)-, gadolinium (Gd)-, 19F- and copper (Cu)-incorporated nanoplatforms for GBM imaging, but also dual-modal or triple-modal nanoprobes. Furthermore, potential obstacles and perspectives for future research and clinical translation of these contrast agents are discussed. We hope this review provides insights for scientists and students with interest in this area. Graphical abstract

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“…Besides, iron superparamagnetic iron oxide nanoparticles were recently approved by the Food and Drug Administration (FDA) as a magnetic resonance agent (Tapeinos et al, 2019). With advances in nanoscience, new nanostructured gadolinium-based contrast gold nanoparticles (Choi et al, 2011;Indrasekara et al, 2013), distinct iron-based nanoparticles such as lipid and peptide-based delivery systems, quantum dots (QDs) (Sun et al, 2014;Cabral Filho et al, 2016), carbon-based nanomaterials (CBNs), including carbon nanotubes (CNT), graphene oxide (GO), and graphene quantum dots (GQDs), (Ashrafizadeh et al, 2020;Kirbas Cilingir et al, 2021), and other types of nanomaterials have been extensively evaluated to improve the detection of glioblastomas, especially in the early stages (Kang et al, 2015;Skripka et al, 2021;Song et al, 2021).…”

Section: Principal Types Of Nanoparticles For Gbm Diagnosismentioning

confidence: 99%

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Gusmão

Matsuo

Barbosa

et al. 2022

Front. Nanotechnol.

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The development of nano-based materials for diagnosis enables a more precise prognosis and results. Inorganic, organic, or hybrid nanoparticles using nanomaterials, such as quantum dots, extracellular vesicle systems, and others, with different molecular compositions, have been extensively explored as a better strategy to overcome the blood-brain barrier and target brain tissue and tumors. Glioblastoma multiforme (GBM) is the most common and aggressive primary tumor of the central nervous system, with a short, established prognosis. The delay in early detection is considered a key challenge in designing a precise and efficient treatment with the most encouraging prognosis. Therefore, the present mini-review focuses on discussing distinct strategies presented recently in the literature regarding nanostructures’ use, design, and application for GBM diagnosis.

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Modular design of multifunctional core-shell tecto dendrimers complexed with copper(II) for MR imaging-guided chemodynamic therapy of orthotopic glioma

Cited by 27 publications

References 56 publications

Copper‐based nanomaterials for cancer theranostics

Copper‐based nanomaterials for cancer theranostics

Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

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