Modulación de la resistencia a norfloxacina de Staphylococcus aureus por Croton A. campestris y Ocimum gratissimum L.

Coutinho, Henrique D.M.; Matias, Edinardo Fágner Ferreira; Santos, Karla K.A.; Santos, Francisco Antônio Vieira dos; Morais-Braga, Maria Flaviana Bezerra; Souza, Teógenes M.; Andrade, Jacqueline Cosmo; Souza, Celestina Elba Sobral de; Tintino, Saulo Relison; Guedes, Gláucia M.M.; Falcão-Silva, Vivyanne S.; Siqueira-Júnior, José P.; Costa, José G.M.

doi:10.7705/biomedica.v31i4.409

Cited by 15 publications

(11 citation statements)

References 24 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The best result was obtained against B. cereus ATCC 33018, when EOBCC reduced the MIC of kanamycin MIC (128 → 8 g/mL). Coutinho et al (2011) have demonstrated that extracts from C. campestris can modulate the norfloxacin effect against two strains of S. aureus, and one of these strains is considered to be resistant to several antibiotics.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and antibiotic modulatory effect of Croton campestris essential oils

Almeida

Rocha

Rodrigues

et al. 2013

Industrial Crops and Products

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and antibiotic modulatory effect of Croton campestris essential oils

Almeida

Rocha

Rodrigues

et al. 2013

Industrial Crops and Products

View full text Add to dashboard Cite

“…It is popularly known as "velame do campo" and is used through infusions of leaves and roots of the plant in alcoholic beverages and teas and is used in Brazilian folk medicine for gastric, hematological, and inflammatory disorders, as well as respiratory problems [14][15][16]. Substantial evidence from the literature indicates that Croton campestris A. St.-Hill displays antibacterial [14,15], antibiotic [15,17], molluscicidal [18], and antiinflammatory properties [19]. Recently, our research group reported the antiulcerogenic activity of the leaf extracts of Croton campestris A. St.-Hill [16].…”

Section: Introductionmentioning

confidence: 99%

Croton campestris A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in Drosophila melanogaster: Protective Role of Gallic Acid

Gomes

Macedo

Rodrigues

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Croton campestris A. St-Hill popularly known as “velame do campo” is a native species of the savannah from northeastern Brazil, being used in folk medicine due to its beneficial effects in the treatment of many diseases, inflammation, detoxification, gastritis, and syphilis; however, its potential use as an antidote against organophosphorus compound poisoning has not yet been shown. Here, the protective effect of the methanolic fraction of C. campestris A. St.-Hill (MFCC) in Drosophila melanogaster exposed to chlorpyrifos (CP) was investigated. Flies were exposed to CP and MFCC during 48 h through the diet. Following the treatments, parameters such as mortality, locomotor behavior, and oxidative stress markers were evaluated. Exposure of flies to CP induced significant impairments in survival and locomotor performance. In parallel, increased reactive oxygen species and lipoperoxidation occurred. In addition, the activity of acetylcholinesterase was inhibited by CP, and superoxide dismutase and glutathione S-transferase activity was induced. Treatment with MFCC resulted in a blockage of all CP-induced effects, with the exception of glutathione S-transferase. Among the major compounds found in MFCC, only gallic acid (GA) showed a protective role against CP while quercetin and caffeic acid alone were ineffective. When in combination, these compounds avoided the toxicity of CP at the same level as GA. As far as we know, this is the first study reporting the protective effect of MFCC against organophosphate toxicity in vivo and highlights the biotechnological potential of this fraction attributing a major role in mediating the observed effects to GA. Therefore, MFCC may be considered a promising source for the development of new therapeutic agents for the treatment of organophosphate intoxications.

show abstract

“…The turbidity of the solution was compared to a 0.5 McFarland scale control. A volume of 100 µL of each inoculum (corresponding to 10% of the total solution) was added to a tube containing 900 µL of 10% Brain Heart Infusion (BHI) [27] and then, 100 µL of these solutions were transferred to 96-well plates. The volume of each well was supplemented with 100 µL of the essential oil added after serial dilution at concentrations ranging from 512 µg/mL to 8 µg/mL.…”

Section: Determination Of the Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria

et al. 2020

Self Cite

View full text Add to dashboard Cite

This study is a pioneer in reporting the antibacterial properties of the species Croton ceanothifolius Baill. The genus Croton belongs to the family Euphorbiaceae composed of numerous species with documented biological activities. However, the pharmacological properties of C. ceanothifolius remain poorly understood. The leaves of this plant were submitted to hydrodistillation for essential oil (CcEO) extraction and the phytochemical characterization of the oil was performed by GC/MS. The minimum inhibitory concentration of the CcEO was determined for the evaluation of antibacterial activity against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The antibiotic-modulating activity of the oil, in combination with antibiotics, was also evaluated. The combination of the CcEO with penicillin, norfloxacin, and gentamicin presented a synergistic effect. This effect was more significant for the association with antibiotics of the quinolone and aminoglycoside classes against Escherichia coli. The association of oil with gentamicin showed better results with regard to the Gram-positive strain. The association of the oil with norfloxacin against P. aeruginosa also showed synergism, but the association with penicillin did not change the effect of this antibiotic. Thus, it is concluded that C. ceanothifolius essential oil selectively potentiates the action of antibiotics against multiresistant strains.

show abstract

Modulación de la resistencia a norfloxacina de Staphylococcus aureus por Croton A. campestris y Ocimum gratissimum L.

Cited by 15 publications

References 24 publications

Chemical composition, antibacterial and antibiotic modulatory effect of Croton campestris essential oils

Chemical composition, antibacterial and antibiotic modulatory effect of Croton campestris essential oils

Croton campestris A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in Drosophila melanogaster: Protective Role of Gallic Acid

Essential Oil of Croton ceanothifolius Baill. Potentiates the Effect of Antibiotics against Multiresistant Bacteria

Contact Info

Product

Resources

About