Modifizierte Technik zur autologen Bindehauttransplantation nach Hornhautverätzung

Mönks, Thomas; Busin, Massimo

doi:10.1055/s-2008-1035508

Cited by 4 publications

(4 citation statements)

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“…[3][4][5][6][7][8][9][10][11] Among them was the use of conjunctival flaps, which could restore ocular surface integrity [12][13][14][15] and provide metabolic and mechanical support for corneal healing. 12,16,17 Described by Gunderson, 1 the most accepted and popular technique involved making a 360°peritomy, mobilizing tissue from the upper bulbar conjunctiva, removing the corneal epithelium, and securing the flap to the lower limbal conjunctiva. Coverage of the entire cornea with the conjunctiva obstructed any view of the anterior chamber, 1,2 precluded monitoring of corneal disease progression, and made it difficult to determine the presence and progress of secondary glaucoma.…”

Section: Commentmentioning

confidence: 99%

Microsurgical Approach to the Conjunctival Flap

Khodadoust¹

2003

Arch Ophthalmol

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To describe a microsurgical approach to a selective pedunculated conjunctival flap for the treatment of chronic corneal ulceration with or without corneal perforation, and to present the results of 50 consecutive cases. Design: Retrospective, noncomparative case series and case reports. Patients: All patients who had microsurgical conjunctival flap procedures for the treatment of chronic corneal ulcers between 1982 and 1996 at the Connecticut Eyecare Center, New Haven. Interventions: Partial pedunculated conjunctival flap surgery. Methods: Review of the initial ocular diagnoses and characteristics as well as retrospective study of the postoperative course. Main Outcome Measures: Resolution of the corneal ulcer and postoperative stability of the conjunctival flap. Results: Sixty-two percent of the corneal ulcers treated were nonperforated, and 38% were perforated. The diagnoses included herpes simplex virus (14 patients), bacterial ulcer (11 patients), rheumatoid arthritis (8 patients), aphakic bullous keratopathy (6 patients), graft rejection (4 patients), herpes zoster virus (5 patients), and other (2 patients). Postoperatively, 94% of the conjunctival flaps were stable, and 3% had failed. The procedures were definitive in 64% of cases and temporary in 36%; 61% of patients received a corneal transplant 6 to 24 months postoperatively, and in 38% the flaps were removed 6 to 12 months after the original lesion had healed. Conclusion: A selective pedunculated conjunctival flap is an effective and practical surgical approach to the treatment of perforated and nonperforated corneal ulcers that have not responded to other types of medical therapy.

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Section: Commentmentioning

confidence: 99%

Microsurgical Approach to the Conjunctival Flap

Khodadoust¹

2003

Arch Ophthalmol

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“…However, the procedure of Meller et al did not address tear deficiency because no conjunctiva was transplanted (goblet cells derive from a cellular lineage separate from LESCs) and a sterile corneal perforation occurred. Bilateral ocular surface diseases (but not GVHD) have been treated previously by HLA-matched allogenic transplantation of conjunctiva with or without limbus …”

Section: Discussionmentioning

confidence: 99%

“…Best spectacle-corrected visual acuity (BSCVA) was 20/200 OD and light perception in the left eye. In February 2015, a transplant of conjunctiva and LESCs from the same brother was performed in the right eye according to a modification of the technique described previously . Postoperative treatment included only corticosteroid and tetracycline ointment.…”

Section: Report Of Casesmentioning

confidence: 99%

Conjunctival and Limbal Transplantation From the Same Living-Related Bone Marrow Donor to Patients With Severe Ocular Graft-vs-Host Disease

Busin¹,

Giannaccare

Sapigni³

et al. 2017

JAMA Ophthalmol

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“…The concept of ocular surface reconstruction was introduced with the application of autologous conjunctiva for unilateral ocular chemical alkali burns [25]. Since then, several surgical approaches have been developed with the aim of restoring the corneal epithelium on the diseased ocular surface.…”

Section: Limbal Stem Cell Deficiency (Lscd)mentioning

confidence: 99%

Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface

Casaroli-Marano

Nieto‐Nicolau

Martínez-Conesa

et al. 2015

JCM

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The integrity and normal function of the corneal epithelium are crucial for maintaining the cornea’s transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio replacement—cultured limbal epithelial transplantation (CLET) and cultured oral mucosal epithelial transplantation (COMET)—present very encouraging clinical results for treating limbal stem cell deficiency (LSCD) and restoring vision. Another emerging therapeutic approach consists of obtaining and implementing human progenitor cells of different origins in association with tissue engineering methods. The development of cell-based therapies using stem cells, such as human adult mesenchymal or induced pluripotent stem cells (IPSCs), represent a significant breakthrough in the treatment of certain eye diseases, offering a more rational, less invasive, and better physiological treatment option in regenerative medicine for the ocular surface. This review will focus on the main concepts of cell-based therapies for the ocular surface and the future use of IPSCs to treat LSCD.

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Modifizierte Technik zur autologen Bindehauttransplantation nach Hornhautverätzung

Abstract: The modified conjunctival plastic employed in the two cases reported herein led to excellent anatomic results while allowing partial recovery of corneal transparency and improvement of vision.

Cited by 4 publications

References 0 publications

Microsurgical Approach to the Conjunctival Flap

Microsurgical Approach to the Conjunctival Flap

Conjunctival and Limbal Transplantation From the Same Living-Related Bone Marrow Donor to Patients With Severe Ocular Graft-vs-Host Disease

Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface

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