Modified volumetric capnography-derived parameter: A potentially stable indicator in monitoring cardiopulmonary resuscitation efficacy in a porcine model

Xu, Jun; Yu, Xuezhong; Zhang, Lili; Fu, Yangyang; Jin, Kui; Yin, Lu; Yu, Shanshan; Liu, Danyu

doi:10.1016/j.resuscitation.2020.02.039

Cited by 9 publications

(14 citation statements)

References 25 publications

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“…Another Vcap-derived parameter, the volume of CO 2 eliminated per min (V'CO 2 ), can reflect metabolic CO 2 production, provided that ventilation and perfusion conditions remain unchanged (15). According to the results of our previous animal experiments (20), the accumulated and produced CO 2 is eliminated quickly by hyperventilation, as manifested by a rapid increase in V'CO 2 within 2-3 min after the change in ventilation status. The V'CO 2 then gradually decreases to a stable level, reflecting the true metabolic status of the body.…”

Section: Introductionmentioning

confidence: 86%

“…Animal preparation procedures, including anesthesia, fixation, mechanical ventilation, and instrumentation methodology, were undertaken as previously described (20). The catheter position, pressure probe, and flow probe placement are shown in Figure 1.…”

Section: Animal Preparationmentioning

confidence: 99%

“…In the first session of the experiment, no vasoactive drugs, including epinephrine or electric defibrillation, were used. Methods of CA induction and experimental processes were used as described previously (20). Briefly, ventricular fibrillation (VF) was induced after recording the baseline parameters.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…We resolved this problem using an ITD since its design principle allows the exhaled gas to be discharged in the compression phase and prevents the gas from entering the decompression phase (17). The reasons for this are explained in detail elsewhere (20).…”

Section: Experimental Protocolmentioning

confidence: 99%

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New volumetric capnography-derived parameter: a potentially valuable tool for detecting hyperventilation during cardiopulmonary resuscitation in a porcine model

et al. 2021

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Background: Volumetric capnography is increasingly being applied in cardiopulmonary resuscitation.However, during cardiopulmonary resuscitation, the abnormal ventilation state affects the monitoring effect of the most commonly used capnography-derived parameter, the partial carbon dioxide end-tidal pressure (PetCO 2 ). In this study, we evaluated the ability of a new volumetric capnography-derived parameter, the ratio between the PetCO 2 and the volume of carbon dioxide (CO 2 ) eliminated per min and per kilogram of body weight, for detecting hyperventilation during cardiopulmonary resuscitation. Methods: We used 12 porcine models of primary ventricular fibrillation-induced cardiac arrest. Ventricular fibrillation was induced and left untreated for 4 min. Standardized chest compressions were performed throughout the experiment using mechanical cardiopulmonary resuscitation. Following 5 min of normal ventilation as a washout period, each animal underwent 4 types of ventilation. The main outcome measures were the PetCO 2 , the ratio between the PetCO 2 and the volume of CO 2 eliminated per min and per kilogram of body weight with each ventilation type. Results: Different ventilation types had a significant effect on the volumetric capnography-derived parameters. The PetCO 2 and ratio between the PetCO 2 and the volume of CO 2 eliminated per min and per kilogram of body weight values during cardiopulmonary resuscitation was significantly higher in non-hyperventilating than in hyperventilating animals. The ratio reflected hyperventilation accuratelyand immediately, with an area under the curve (AUC) of 0.98. The optimal cut-off point of the ratio for discriminating hyperventilation from non-hyperventilation was 6.36, with a sensitivity and specificity of 0.99 and 0.89, respectively. Conclusions:The ratio between the PetCO 2 and the volume of CO 2 eliminated per min and per kilogram of body weight showed good performance in discriminating hyperventilation from non-hyperventilation and was sensitive to changes in ventilation status. This ratio may be a valuable clinical indicator for monitoring the ventilation status during cardiopulmonary resuscitation.

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Section: Introductionmentioning

confidence: 86%

Section: Animal Preparationmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

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New volumetric capnography-derived parameter: a potentially valuable tool for detecting hyperventilation during cardiopulmonary resuscitation in a porcine model

et al. 2021

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“…Para la fase II se seleccionó un modelo porcino, de comportamiento similar, desde el punto de vista funcional, a los seres humanos. Cabe señalar que este modelo ha sido ampliamente utilizado en múltiples estudios experimentales como paso intermedio al uso en humanos (15) . La fase final (uso del prototipo en seres humanos) exige en primer lugar la prueba en una cohorte de cinco pacientes para comprobar su seguridad y funcionamiento correcto, además de la replicación de los parámetros ventilatorios del modelo estándar y, en segundo lugar, la selección de una cohorte abierta de pacientes que requieran ser ventilados con el prototipo (12) .…”

Section: Introductionunclassified

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

García-Castro

Latorre-Galeano

Giraldo-Montoya

et al. 2021

Rev Peru Med Exp Salud Publica

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A raíz de la pandemia generada por el SARS-CoV-2, los sistemas de salud de los distintos países han experimentado un dramático aumento en la ocupación de las unidades de cuidado intensivo y, por ende, una alta demanda de ventiladores mecánicos. En este artículo se propone un protocolo de pruebas de ventiladores mecánicos de bajo costo en modelos porcinos, como parte del desarrollo de equipos biomédicos que pueden apoyar la crisis sanitaria suscitada por la pandemia. El protocolo aborda aspectos que incluyen la fase previa a la prueba, el manejo anestésico, de vía aérea, seguimiento de laboratorio, recuperación y seguimiento del animal. Como resultado, se presenta a la comunidad académica un protocolo de validación de prototipo de ventilador mecánico en espécimen porcino como un referente para su aplicación y revalidación por parte de grupos interesados en el desarrollo de tecnologías locales de bajo costo.

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Assessment of a new volumetric capnography-derived parameter to reflect compression quality and to predict return of spontaneous circulation during cardiopulmonary resuscitation in a porcine model

Zhang

Jin

Sun

et al. 2021

J Clin Monit Comput

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Modified volumetric capnography-derived parameter: A potentially stable indicator in monitoring cardiopulmonary resuscitation efficacy in a porcine model

Cited by 9 publications

References 25 publications

New volumetric capnography-derived parameter: a potentially valuable tool for detecting hyperventilation during cardiopulmonary resuscitation in a porcine model

New volumetric capnography-derived parameter: a potentially valuable tool for detecting hyperventilation during cardiopulmonary resuscitation in a porcine model

Protocolo de prueba de ventilador mecánico para atención de pacientes con COVID-19 en modelo porcino

Assessment of a new volumetric capnography-derived parameter to reflect compression quality and to predict return of spontaneous circulation during cardiopulmonary resuscitation in a porcine model

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