Assessment of a new volumetric capnography-derived parameter to reflect compression quality and to predict return of spontaneous circulation during cardiopulmonary resuscitation in a porcine model

Zhang, Lili; Jin, Kui; Sun, Feng; Xu, Jun; Yu, Xuezhong; Zhu, Huadong; Fu, Yangyang; Liu, Danyu; Yu, Shanshan

doi:10.1007/s10877-020-00637-1

Cited by 5 publications

(7 citation statements)

References 34 publications

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“…Some authors suggested that VCO 2 and VCO 2 /kg were also good predictors of ROSC 17 , 20 , 21 , although these parameters did not demonstrate utility for this purpose in our study. Most of these studies induced a ventricular-fibrillation cardiac arrest.…”

Section: Discussioncontrasting

confidence: 79%

“…Zhang et al found that EtCO 2 was a useful parameter to predict ROSC, and that VCO 2 /kg ratio had similar capacity to predict ROSC in an experimental porcine cardiac arrest model 20 . This group also analyzed the relationship between EtCO 2 /VCO 2 /kg and ventilation during CPR in an experimental study with adult pigs, finding that this ratio showed good performance in discriminating hyperventilation from non-hyperventilation 13 .…”

Section: Discussionmentioning

confidence: 99%

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Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest

Navazo

Manrique

Fernández

et al. 2023

Sci Rep

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A secondary analysis of a randomized study was performed to study the relationship between volumetric capnography (VCAP) and arterial CO2 partial pressure (PCO2) during cardiopulmonary resuscitation (CPR) and to analyze the ability of these parameters to predict the return of spontaneous circulation (ROSC) in a pediatric animal model of asphyxial cardiac arrest (CA). Asphyxial CA was induced by sedation, muscle relaxation and extubation. CPR was started 2 min after CA occurred. Airway management was performed with early endotracheal intubation or bag-mask ventilation, according to randomization group. CPR was continued until ROSC or 24 min of resuscitation. End-tidal carbon dioxide (EtCO2), CO2 production (VCO2), and EtCO2/VCO2/kg ratio were continuously recorded. Seventy-nine piglets were included, 26 (32.9%) of whom achieved ROSC. EtCO2 was the best predictor of ROSC (AUC 0.72, p < 0.01 and optimal cutoff point of 21.6 mmHg). No statistical differences were obtained regarding VCO2, VCO2/kg and EtCO2/VCO2/kg ratios. VCO2 and VCO2/kg showed an inverse correlation with PCO2, with a higher correlation coefficient as resuscitation progressed. EtCO2 also had an inverse correlation with PCO2 from minute 18 to 24 of resuscitation. Our findings suggest that EtCO2 is the best VCAP-derived parameter for predicting ROSC. EtCO2 and VCO2 showed an inverse correlation with PCO2. Therefore, these parameters are not adequate to measure ventilation during CPR.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest

Navazo

Manrique

Fernández

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Some authors suggested that VCO 2 and VCO 2 /kg were also good predictors of ROSC [14,17,18], although these parameters did not demonstrate utility for this purpose in our study. Most of these studies induced a ventricular-brillation cardiac arrest.…”

Section: Discussioncontrasting

confidence: 65%

“…Zhang et al found that EtCO 2 was a useful parameter to predict ROSC, and that VCO 2 /kg ratio had similar capacity to predict ROSC in an experimental porcine cardiac arrest model [17]. This group also analyzed the relationship between EtCO 2 /VCO 2 /kg and ventilation during CPR in an experimental study with adult pigs, nding that this ratio showed good performance in discriminating hyperventilation from nonhyperventilation [10].…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Volumetric Capnography, Ventilation During Cardiopulmonary Resuscitation and Return of Spontaneus Circulation in an Experimental Model of Pediatric Asphyxial Cardiac Arrest

Navazo

Manrique

Fernández

et al. 2022

Preprint

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Purpose To study the relationship between volumetric capnography (VCAP) and arterial CO2 partial pressure (PCO2) during cardiopulmonary resuscitation (CPR) and to analyze the ability of these parameters to predict the return of spontaneous circulation (ROSC) in a pediatric animal model of asphyxial cardiac arrest (CA). Methods Secondary analysis of a randomized study. Asphyxial CA was induced by muscle relaxation and extubation. CPR was started two minutes after CA occurred. Airway management was performed with early endotracheal intubation or bag-mask ventilation, according to randomization group. CPR was continued until ROSC or 24 minutes of resuscitation. End-tidal carbon dioxide (EtCO2), CO2 production (VCO2), and EtCO2/VCO2/kg ratio were continuously recorded. Results Seventy-nine piglets were included, 26 (32.9%) of whom achieved ROSC. EtCO2 was the best predictor of ROSC (AUC 0.72, p < 0.01 and optimal cutoff point of 21.6 mmHg). No statistical differences were obtained regarding VCO2, VCO2/kg and EtCO2/VCO2/kg ratios. VCO2 and VCO2/kg showed an inverse correlation with PCO2, with higher a correlation coefficient as resuscitation progressed. EtCO2 also had an inverse correlation with PCO2 from minute 18 to 24 of resuscitation. Conclusion Our findings suggest that EtCO2 is the best VCAP-derived parameter for predicting ROSC. EtCO2 and VCO2 showed an inverse correlation with PCO2. Therefore, these parameters are not adequate to measure ventilation during CPR.

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Monitoring Ventilation

Briley,

Bailey,

Love

2024

Veterinary Anesthesia and Analgesia

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Assessment of a new volumetric capnography-derived parameter to reflect compression quality and to predict return of spontaneous circulation during cardiopulmonary resuscitation in a porcine model

Cited by 5 publications

References 34 publications

Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest

Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest

Relationship Between Volumetric Capnography, Ventilation During Cardiopulmonary Resuscitation and Return of Spontaneus Circulation in an Experimental Model of Pediatric Asphyxial Cardiac Arrest

Monitoring Ventilation

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