Modified Th2 Responses at High-Dose Exposures to Allergen

Jeal, H.; Draper, Adrian; Harris, Jessica; Taylor, Alison; Cullinan, Paul; Jones, Meinir

doi:10.1164/rccm.200506-964oc

Cited by 78 publications

(78 citation statements)

References 22 publications

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“…In a cross-sectional study of rat workers, the risk of IgE sensitization was attenuated among those who handled the greatest number of rats per day, but the prevalence of rat-specifi c IgG and IgG4 was highest among this group [35]. Those in this highest exposure group were also less likely to have rat-associated allergic symptoms than workers with lower rat exposure.…”

Section: Ige Sensitizationmentioning

confidence: 98%

Role of mouse allergens in allergic disease

Matsui

2009

Curr Allergy Asthma Rep

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Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner cities. Inner city homes in major northeastern and midwestern US urban centers have levels as much as 100-fold higher than those found in other geographic regions. In addition, about 25% of inner city children with asthma have evidence of IgE sensitization to mouse. Several studies have shown that the combination of sensitization and exposure to higher levels of mouse allergen is associated with substantial asthma morbidity, including hospitalizations. Integrated pest management is efficacious in reducing mouse allergen levels and is recommended for sensitized patients with asthma. However, its impact on clinical outcomes has not yet been proven.

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Section: Ige Sensitizationmentioning

confidence: 98%

Role of mouse allergens in allergic disease

Matsui

2009

Curr Allergy Asthma Rep

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“…24,25 A recent report on serological responses to rat urinary allergens has confirmed that a ''modified T H 2 response'' can also occur among animal handlers. 26 The reason for calling the response to cat, dog, mouse, or rat allergens a ''modified T H 2 response'' is both that expression of IgG 4 is IL-4-dependent and that this response does not include evidence for a T H 1 response. [24][25][26][27] The reason for regarding it as a form of tolerance is that individuals who have allergen-specific IgG 4 antibody without IgE antibody do not experience symptoms.…”

Section: Immune Responses To Indoor Allergensmentioning

confidence: 99%

“…26 The reason for calling the response to cat, dog, mouse, or rat allergens a ''modified T H 2 response'' is both that expression of IgG 4 is IL-4-dependent and that this response does not include evidence for a T H 1 response. [24][25][26][27] The reason for regarding it as a form of tolerance is that individuals who have allergen-specific IgG 4 antibody without IgE antibody do not experience symptoms. The mechanisms by which high exposure to one type of allergen could give rise to tolerance are not clear.…”

Section: Immune Responses To Indoor Allergensmentioning

confidence: 99%

The role of indoor allergens in chronic allergic disease

Platts-Mills

2007

Journal of Allergy and Clinical Immunology

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“…A window of allergen exposure causing eosinophilia was evident particularly for animals sensitized when young and challenged as adults. Such attenuation of the allergic response at higher allergen exposures has been noted in clinical studies of cat, dust mite, and lab animal allergic populations (Jeal et al, 2006) and has been described as a modified T H 2 response. It is associated with lower rates of specific IgE and an increased frequency of specific IgG production.…”

Section: Discussionmentioning

confidence: 77%

Contributions of Age and Sex to Heterogeneity of Symptoms and Effectiveness of Secondary Prevention Strategies in Asthma as Modeled in the Guinea Pig

Regal

Meehan

et al. 2007

Journal of Immunotoxicology

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Previous studies in a guinea pig model of asthma have suggested that age and sex contribute both to the profile of asthma symptoms, i.e., asthma heterogeneity, as well as to the success of primary prevention strategies. The present study investigated the contributions of age and sex to the severity of central vs. peripheral airway hyperresponsiveness as well as to the effectiveness of secondary preventions strategies for asthma as modeled in the guinea pig. Experimental groups: Young/Young, sensitized and challenged before sexual maturity; Young/Adult, sensitized young and challenged after sexual maturity; Adult/Adult, sensitized and challenged after sexual maturity. Males and females were sensitized IP with 0.5 mg/kg ovalbumin (OVA) and challenged intratracheally with varying doses of OVA. Cellular infiltration into lung and lavage fluid, OVA specific IgG 1 as well as airway hyperresponsiveness to intravenous methacholine were determined 24 hr later. Airway hyperresponsiveness in central airways and peripheral lung was assessed by measurement of airway resistance, tissue damping and tissue elastance. Airway hyperresponsiveness with allergen sensitization and challenge was evident in male and female Adult/Adult animals and male Young/Young animals. Airway hyperresponsiveness in female Young/Young animals was not significant, despite marked airway eosinophilia. Changes in tissue elastance were more evident in OVA treated Adult/Adult compared to Young/Young animals. As allergen exposure decreased, a reduction in inflammation was seen in young females before other age sex groups. OVA induced increases in eosinophils were more pronounced in Young/Adult compared to Adult/Adult animals. Our results suggest that in asthmatic children, females may clinically Received 21 August 2006; accepted 27 October 2006. Address correspondence to Jean F. Regal, Department of Biochemistry and Molecular Biology, Medical School Duluth, University of Minnesota, 1035 University Dr., Duluth, Minnesota 55812, USA; e-mail: jregal@d.umn.edu benefit most from secondary prevention strategies to limit allergen exposure. In adult asthmatics, changes in tissue elastance may be significant, and secondary prevention strategies may be more effective in those sensitized as children compared to those sensitized as adults.

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Modified Th2 Responses at High-Dose Exposures to Allergen

Cited by 78 publications

References 22 publications

Role of mouse allergens in allergic disease

Role of mouse allergens in allergic disease

The role of indoor allergens in chronic allergic disease

Contributions of Age and Sex to Heterogeneity of Symptoms and Effectiveness of Secondary Prevention Strategies in Asthma as Modeled in the Guinea Pig

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