Modified protocol including topical minocycline in orabase to manage medication‐related osteonecrosis of the jaw cases

Abstract

In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat MRONJ lesions.

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

“…The authors reported controlling pain, infection, and less dependence on home care using topical minocycline (Karasneh et al, 2016). They concluded that its use as a treatment for BRONJ requires large and well-controlled prospective clinical studies (Karasneh et al, 2016). Bone morphogenetic proteins (BMPs) BMPs are multi-functional growth factors that belong to the transforming growth factor-ß (TGFß) superfamily (Begam, Nandi, Kundu, & Chanda, 2017;Lombard et al, 2016) and are considered the most important growth factors implied in bone and cartilage formation during development, growth, and healing (Begam et al, 2017;Lombard et al, 2016).…”

“…Tetracyclines (doxycycline and minocycline among others) are a bacteriostatic group of broad spectrum antibiotics which inhibit protein synthesis by binding to 30S bacterial ribosomes and preventing the access of aminoacyl tRNA to the receptor site on the mRNAribosome complex (Javed & Kohli, 2010). These drugs were described more than 50 years ago and since then have been used in the treatment (Karasneh et al, 2016). The authors reported controlling pain, infection, and less dependence on home care using topical minocycline (Karasneh et al, 2016).…”

“…These drugs were described more than 50 years ago and since then have been used in the treatment (Karasneh et al, 2016). The authors reported controlling pain, infection, and less dependence on home care using topical minocycline (Karasneh et al, 2016). They concluded that its use as a treatment for BRONJ requires large and well-controlled prospective clinical studies (Karasneh et al, 2016).…”

Antiresorptive treatment-associated ONJ

“…Bermudez-Bejarano et al, 2017). Accordingly, it includes administration of systemic antibiotics, mouth rinses with chlorhexidine, topical applied minocycline(Karasneh, Al-Eryani, Clark, & Sedghizadeh, 2016) and chlorhexidine mouth gel for local disinfection of the exposed bone.Oral antibiotics usually include penicillin-based regimens. Accordingly, it includes administration of systemic antibiotics, mouth rinses with chlorhexidine, topical applied minocycline(Karasneh, Al-Eryani, Clark, & Sedghizadeh, 2016) and chlorhexidine mouth gel for local disinfection of the exposed bone.Oral antibiotics usually include penicillin-based regimens.…”

“…Non-surgical management of ONJ seeks to reduce local inflammation and intraoral bacterial load and attain symptom control-in the context of preventing ONJ deterioration(Table 4). Accordingly, it includes administration of systemic antibiotics, mouth rinses with chlorhexidine, topical applied minocycline(Karasneh, Al-Eryani, Clark, & Sedghizadeh, 2016) and chlorhexidine mouth gel for local disinfection of the exposed bone. Oral antibiotics usually include penicillin-based regimens.…”