Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis

Filho, Manoel D. Souza; Medeiros, Jand Venes R.; Vasconcelos, Daniel Fernando Pereira; Silva, Durcilene Alves da; Leódido, Ana Carolina Machado; Fernandes, Hygor Ferreira; Silva, Felipe Rodolfo Pereira da; França, Luiz Felipe C.; Lenardo, David Di; Pinto, Giovanny R.

doi:10.1016/j.ijbiomac.2017.09.087

Cited by 32 publications

(13 citation statements)

References 69 publications

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“…The metabolities mainly the secondaries metabolities as phenolics and flavonoids are necessaries for the plant survive, including activities in growth regulation, enzyme inhibition, antioxidant activity and ultraviolet light (UV) (Jia et al, 2014;Räisänen et al, 2008). The phenolic compounds and flavonoids are the major groups referred to with antioxidant activity in hydrophilic or lipophilic systems, such as cardanol, comprised among the phenolic lipids found in Anacardium occidentale, with antiinflammatory action (Cossetin et al, 2019;Souza Filho et al, 2018a). Under stressful environmental conditions, as observed in the Caatinga, there is a natural increase in the concentration of phenolic compounds as a self-defense mechanism (Sharma et al, 2019).…”

Section: Chemical Composition Of Plants Observed In the Caatingamentioning

confidence: 99%

Caatinga: barn of antioxidant and nutraceutical bio-actives

Diniz

Santos²,

Barbosa³

et al. 2022

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The Caatinga, of Brazilian exclusivity, is compound by adapted plants for the climate-specific conditions present in this region. The natural resources in this phytogeography domain are used for local communities as foods source, regional economics develops, and traditional medicine. Folk medicine is applied as a local tradition through the fraction of the plants, such as roots, leaves, and fruits, to treat inflammation, tumor, metabolic or degenerative diseases. Although the technological pharmaceutical industrial process shows exponential development in benefits for human health, the search for new treatments, naturals, and alternatives linked with the significant consciousness of the populations some knowledge about folk medicine and their natural compounds are not vast. In this way, the present review aimed to realize the systematic research considering 26 species endemics in Caatinga and their most significant biological potential. As a result, it was observed that have more studies with the antioxidative and immunomodulatory activities. The previous knowledge shows the relation between the accumulation of reactive oxygen species (ROS) and the development of different immunological diseases. With this review, we propose to contribute to the biotechnological potential of the Caatinga for science health.

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Section: Chemical Composition Of Plants Observed In the Caatingamentioning

confidence: 99%

Caatinga: barn of antioxidant and nutraceutical bio-actives

Diniz

Santos²,

Barbosa³

et al. 2022

RSD

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“…In pharmaceutical applications, natural cashew gum has been used in conjunction with phthalocyanines to develop a layer-by-layer film for an electrochemical sensor to detect dopamine, with an acceptable detection limit for the pharmaceutical industry (Araújo et al 2012). Cashew gum has also been used as a pharmaceutical excipient (a natural muco-adhesive polymer) in dental pastes containing aceclofenac (AC) for pain management in periodontitis (Hasnain et al 2018); in bucal-adhesive curcumin tablets with the potential to improve the bioavailability of the active ingredient (Gowthamarajan et al 2012); and in an Orabase formulation for periodontitis treatment (Souza Filho et al 2018). The dental paste demonstrated sustained AC release over 6 h with good oral mucosa adhesion, resulting in effectual management of dental inflammation and pain through prolonged local delivery of AC in periodontitis treatment (Hasnain et al 2018).…”

Section: Anacardium Occidentale L (Anacardiaceae)mentioning

confidence: 99%

“…The bucal-adhesive tablet bypasses first pass metabolism and provides sustained release of curcumin, a phenolic compound whose therapeutic effectiveness is often limited due to its poor absorption from the gastrointestinal tract (Gowthamarajan et al 2012). The Orabase formulation with cashew gum polysaccharide decreased inflammation and bone loss (hallmarks in experimental periodontitis) (Souza Filho et al 2018). A. occidentale was also used to produce nanoparticles in varied applications.…”

Section: Anacardium Occidentale L (Anacardiaceae)mentioning

confidence: 99%

Food Composition Data: Edible Plants in Cerrado

et al. 2021

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181negative correlation between the in vitro potential of many molecules and their ADME/T (absorption, distribution, metabolism, excretion/toxicity) profile is generally noted (Gleeson et al. 2011). Synthetic compounds present a significantly lower number of chiral centers and are both smaller and present greater flexibility, which results in weaker, less specific activity (Feher and Schmidt 2003). In contrast, plantderived natural products present a diversity of bioactive compounds with differing chemical scaffolds (Atanasov et al. 2015). Plant-derived products possess properties, such as binding affinities for specific proteins, that are evolutionary optimized (Appendino et al. 2010;Hunter 2008). Such characteristics make plant-derived products more advantageous for conducting ADME/T tests (Atanasov et al. 2015). Another advantage in drug discovery using medicinal plants is the known good correlation between ethnopharmacological information (well documented) and the medical use of the plant. Around 80% of identified compounds present some ethnomedicinal use, whether identical or related to current usage of the active plant elements (Fabricant and Farnsworth 2001). Further, technological advances in systems biology, bioinformatics, plant specialized metabolism, and synthetic biology present opportunities through which the medicinal properties of plants are discovered, utilized, and expanded toward developing new herb-inspired medicines (Li and Weng 2017). Accordingly, plant-derived natural products still represent a valuable source for drug discovery, this, motivated by global public health challenges, such as COVID-19, HIV/AIDS, malaria, hypertension, diabetes, and cancer (Thomford et al. 2018). About a quarter of all Food and Drug Administration (FDA)-and/or European Medical Agency (EMA)-approved drugs are plant-derived (Patridge et al. 2016;Thomford et al. 2018).In this context, Brazil possesses various biomes with a great portion of the world's biodiversity and approximately 20% of the plants and microorganisms on the planet (Calixto 2000). Among these biomes, the Cerrado is a neotropical savanna with rich flora (Klink and Machado 2005). Over 13,127 highly endemic plant species have been recorded within this biome (Myers et al. 2000;Overbeck et al. 2015;Silva and Bates 2002;Silveira et al. 2016). Yet, in regard to environmental conservation, only 41% of the original Cerrado still remains as native vegetation (Soares-Filho et al. 2014). This reduction is due to anthropogenic activities, such as monoculture, pasture expansions, mineral extraction, and the growth of urban areas (Faleiro et al. 2013). Considering only agricultural activity between 2002 and 2009, an estimated loss of 92,712 km 2 of natural Cerrado area has occurred (Overbeck et al. 2015). Preservation policies in Brazil need improvement, yet only 7% of the Cerrado is under legal protection (Soares-Filho et al. 2014).Both the bio-prospecting potential of the Cerrado for medicinal species and knowledge concerning traditional medicines are disappear...

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“…The use of anti-inflammatory agents has been proposed as another adjuvant approach in periodontitis treatment [ 13 ]. For example, the application of orabase cashew gum polysaccharide reduced alveolar bone destruction and inflammatory cytokine expression in a ligature-induced periodontitis model [ 14 ], and rice peptide injections inhibited bone loss and reduced osteoclast numbers compared to untreated experimental periodontitis [ 15 ]. These could represent therapeutic options to control the progression of periodontal disease and to promote a microenvironment conducive to periodontal regeneration.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

et al. 2021

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Background and Aim: Fibrin forms in the coagulation process, enhancing local hemostatic properties and promoting wound healing. The study aimed to evaluate the efficacy of bubaline-derived fibrin glue in silk ligature-induced periodontitis rats. Materials and Methods: Bubaline blood–derived fibrin glue was prepared using cryoprecipitation and cryocentrifugation. Periodontitis was induced in rats by placing 5-0 silk ligatures around the mandibular first molars. The animals were divided into two groups: (1) Non-treatment and (2) bubaline fibrin glue–treated groups. Plaque, gingival inflammation, and mobility index were scored on days 1, 7, and 14 after intervention. Histological examinations were performed. The mRNA expression of inflammatory cytokines and growth factors was evaluated using a real-time polymerase chain reaction. Ligature-induced periodontitis was confirmed by the increase in inflammatory cell infiltration as well as histological bone and attachment loss. Results: Compared to the non-treatment group, bubaline fibrin glue application reduced mononuclear cell infiltration into periodontal tissues corresponding to the reduction of collagen destruction. On days 7 and 14 after intervention, the inflammatory score and histological attachment loss were significantly lower in the bubaline fibrin glue–treated group than in the non-treatment group. A significant reduction in histological bone loss was observed in the treated group on day 7. Bubaline fibrin glue application led to a significant reduction of Tnfa and Il1b mRNA levels, while an increased expression of Pdgfa, Tgfb1, and Il10 was observed compared with the control. Conclusion: Bubaline fibrin glue could be beneficial in periodontitis treatment aiming to reduce inflammation and delay the progression of periodontal disease.

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Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis

Cited by 32 publications

References 69 publications

Caatinga: barn of antioxidant and nutraceutical bio-actives

Caatinga: barn of antioxidant and nutraceutical bio-actives

Food Composition Data: Edible Plants in Cerrado

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

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