Modified Prosthetic Vascular Conduits

Kapadia, Muneera R.; Popowich, Daniel A.; Kibbe, Melina R.

doi:10.1161/circulationaha.107.714170

Cited by 111 publications

(74 citation statements)

References 60 publications

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“…23 Chemical modulation of polyurethanes has resulted in the development of biostable polymers such as PCU, and with the incorporation of POSS nanoparticles improved mechanical strength, modulus, and rigidity. 24 Oxygen plasma treatment increased both the hydrophilicity of the POSS-PCU surface and subsequent HUVEC growth.…”

Section: Discussionmentioning

confidence: 99%

Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Chong

Turner

Gadegaard

et al. 2015

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Chong

Turner

Gadegaard

et al. 2015

European Journal of Vascular and Endovascular Surgery

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“…Poly(ethylene terephthalate) (PET®, Dacron), expanded poly(tetrafluoroethylene) (ePTFE, Gore-Tex®), and heparinbonded ePTFE (Propaten®) have demonstrated some degree of success as peripheral vascular grafts for larger vessel diameters due to high flow rates of blood past the luminal surface (Kapadia et al, 2008). In smaller diameter vessels (3-6 mm), early graft occlusion is frequently encountered, resulting from thrombogenicity of the synthetic surface and anastomotic hyperplasia (Chan-Park et al, 2009).…”

Section: Synthetic Prosthesesmentioning

confidence: 99%

Vascular Grafting Strategies in Coronary Intervention

2014

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With the growing need for coronary revascularizations globally, several strategies to restore blood flow to the heart have been explored. Bypassing the atherosclerotic coronary arteries with autologous grafts, synthetic prostheses, and tissue-engineered vascular grafts continue to be evaluated in search of a readily available vascular graft with clinically acceptable outcomes. The development of such a vascular graft including tissue engineering approaches both in situ and in vitro is herein reviewed, facilitating a detailed comparison on the role of seeded cells in vascular graft patency.

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“…Conversely, surfaces that allow specific cell growth have also great medical applicability. For instance, reconstitution of the endothelial cell layer on artificial catheters is desirable because it ensures optimal blood compatibility [18,19].…”

Section: Importance Of Protein-materials Interactions In Med-mentioning

confidence: 99%

Protein conformational changes induced by adsorption onto material surfaces: an important issue for biomedical applications of material science

Ballet¹,

Boulangé²,

Bréchet³

et al. 2010

Bulletin of the Polish Academy of Sciences: Technical Sciences

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Abstract. Protein adsorption on solid surfaces is a widespread phenomenon of large biological and biotechnological significance. Conformational changes are likely to accompany protein adsorption, but are difficult to evidence directly. Nevertheless they have important consequences, since the partial unfolding of protein domains can expose hitherto hidden amino acids. This remodeling of the protein surface can trigger the activation of molecular complexes such as the blood coagulation cascade or the innate immune complement system. In the case of extracellular matrix, it can also change the way cells interact with the material surfaces and result in modified cell behavior. In this review, we present direct and indirect evidences that support the view that some proteins change their conformation upon adsorption. We also show that both physical and chemical methods are needed to study the extent and kinetics of protein conformational changes. In particular, AFM techniques and cryo-electron microscopy provide useful and complementary information. We then review the chemical and topological features of both proteins and material surfaces in relation with protein adsorption. Mutating key amino acids in proteins changes their stability and this is related to material-induced conformational changes, as shown for instance with insulin. In addition, combinatorial methods should provide valuable information about peptide or antibody adsorption on well-defined material surfaces. These techniques could be combined with molecular modeling methods to decipher the rules governing conformational changes associated with protein adsorption.

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Modified Prosthetic Vascular Conduits

Cited by 111 publications

References 60 publications

Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Vascular Grafting Strategies in Coronary Intervention

Protein conformational changes induced by adsorption onto material surfaces: an important issue for biomedical applications of material science

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