Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review

Bakhtiari, Sanaz Soleymani Eil; Karbasi, Saeed; Bahremandi-Toloue, Elahe

doi:10.1016/j.ijbiomac.2020.10.255

Cited by 69 publications

(16 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, PHB is well known and widely investigated in biomedical applications due to its high biodegradability and biocompatibility. PHB is a good substitute for conventional plastics, where mechanical properties are required [13]. The thermodynamic miscibility between polymer (PHB) and nano-clays plays an important role in enhancing the properties of polymer (PHB) blends [14].…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

View full text Add to dashboard Cite

Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As a member of the polyhydroxyalkanoates family, PHB has received considerable attention for several medical applications because of its advantageous properties such as good biocompatibility, nontoxic degradation products, and excellent mechanical strength compared to other polymers in different fields, including tissue engineering. For example, PHB was used as alloy scaffolds coated with ceramic-based stands to improve degradation rate, hydrophobicity, and brittleness . In addition, PHB electrospun fibers were used in various medical applications, as described in Figure .…”

Section: Pbat: Poly(butylene Adipate-co-terephthalate) Fabrication Ap...mentioning

confidence: 99%

“…For example, PHB was used as alloy scaffolds coated with ceramic-based stands to improve degradation rate, hydrophobicity, and brittleness. 318 In addition, PHB electrospun fibers were used in various medical applications, as described in Figure 5.…”

Section: Pbat: Poly(butylene Adipate-co-terephthalate) Fabrication Ap...mentioning

confidence: 99%

Recent Development of Polyhydroxyalkanoates (PHA)-Based Materials for Antibacterial Applications: A Review

Ladhari

Boisvert

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

The diseases caused by microorganisms are innumerable existing on this planet. Nevertheless, increasing antimicrobial resistance has become an urgent global challenge. Thus, in recent decades, bactericidal materials have been considered promising candidates to combat bacterial pathogens. Recently, polyhydroxyalkanoates (PHAs) have been used as green and biodegradable materials in various promising alternative applications, especially in healthcare for antiviral or antiviral purposes. However, it lacks a systematic review of the recent application of this emerging material for antibacterial applications. Therefore, the ultimate goal of this review is to provide a critical review of the state of the art recent development of PHA biopolymers in terms of cutting-edge production technologies as well as promising application fields. In addition, special attention was given to collecting scientific information on antibacterial agents that can potentially be incorporated into PHA materials for biological and durable antimicrobial protection. Furthermore, the current research gaps are declared, and future research perspectives are proposed to better understand the properties of these biopolymers as well as their possible applications.

show abstract

“…However, the fabrication of such complex structures is crucial, and the manufacturing process should provide high reproducibility and accuracy [ 26 ]. Metal powder sintering [ 27 ], polymeric sponge replication [ 28 ], investment casting [ 29 ], and gas foaming [ 30 ] are some conventional manufacturing processes used for the fabrication of 3D scaffolds. The research on the manufacturing of porous scaffolds is mainly at the lab scale; however, the recent innovations in biomaterials for such applications have opened up the opportunity to adopt advanced manufacturing processes as an alternative to producing on-demand porous scaffolds for BTE precisely and accurately [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Material Extrusion 3D Printing (ME3DP) Process Simulations of Polymeric Porous Scaffolds for Bone Tissue Engineering

2023

View full text Add to dashboard Cite

Bone tissue engineering (BTE) is an active area of research for bone defect treatment. Some polymeric materials have recently gained adequate attention as potential materials for BTE applications, as they are biocompatible, biodegradable, inexpensive, lightweight, easy to process, and recyclable. Polyetherimide (PEI), acrylonitrile butadiene styrene (ABS), and polyamide-12 (PA12) are potential biocompatible materials for biomedical applications due to their excellent physical, chemical, and mechanical properties. The current study presents preliminary findings on the process simulations for 3D-printed polymeric porous scaffolds for a material extrusion 3D printing (ME3DP) process to observe the manufacturing constraints and scaffold quality with respect to designed structures (porous scaffolds). Different unit cell designs (ventils, grid, and octet) for porous scaffolds, virtually fabricated using three polymeric materials (PEI, ABS, and PA12), were investigated for process-induced defections and residual stresses. The numerical simulation results concluded that higher dimensional accuracy and control were achieved for grid unit cell scaffolds manufactured using PEI material; however, minimum residual stresses were achieved for grid unit cell scaffolds fabricated using PA12 material. Future studies will include the experimental validation of numerical simulation results and the biomechanical performance of 3D-printed polymeric scaffolds.

show abstract

Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review

Cited by 69 publications

References 96 publications

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Recent Development of Polyhydroxyalkanoates (PHA)-Based Materials for Antibacterial Applications: A Review

Material Extrusion 3D Printing (ME3DP) Process Simulations of Polymeric Porous Scaffolds for Bone Tissue Engineering

Contact Info

Product

Resources

About