Modified natural clinoptilolite with quercetin and quercetin dihydrate and the study of their anticancer activity

Tomečková, Vladimı́ra; Rehákovà, M.; Mojžišová, Gabriela; Magura, Jozef; Wadsten, T.; Zelenáková, Katarína

doi:10.1016/j.micromeso.2011.05.031

Cited by 27 publications

(19 citation statements)

References 22 publications

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“…Thus, loading of flavanols in nanoporous silica systems can stabilize and protect them from degradation, ensuring high loading capacity [22][23][24][25][26][27]. Preliminary studies show that immobilization of quercetin in the mesoporous silica, like MCM-41, successfully stabilized quercetin, improving its antioxidant efficacy [28,29,31]. In addition, the increased specific surface area of mesoporous silica particles could eventually improve the bioavailability of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the increased specific surface area of mesoporous silica particles could eventually improve the bioavailability of bioactive compounds. Application of clinoptilolite zeolite as a carrier of quercetin [29] led to higher cytotoxicity especially for those with particle size up to 200 µm and can be used for treatment of different tumor cell lines. The effect of quercetin alone or in complex with NH 2 -MSN (amino modified Mesoporous Silica Nanoparticles) on proliferation of JR8 human melanoma cells was evaluated by Berlier et al [31] and the results show that the complex with NH 2 -MSN is more effective than quercetin alone, causing about 50% inhibition of cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

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Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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SBA-16 and MCM-41 silica materials were synthesized and modified by post-synthesis method with different amounts of Zn (2 and 4 wt.%). Quercetin, a flavonol compound, was loaded by incipient wetness impregnation method on the pure silica and Zn-modified mesoporous MCM-41 and SBA-16 supports. The parent and drug loaded formulations were characterized by powder XRD, N 2 physisorption, thermal analysis, TEM, UV Vis and FT-IR spectroscopies. The formation of Zn:quercetin complex was studied by FT-IR spectroscopy and quantum-chemical calculations. Loading of quercetin on mesoporous carriers made the sustained delivery of the bioactive compound possible in a buffer with pH = 5.5, typical of dermal formulations. The results from the release experiments are in good accordance with the inter-action energy between the bioactive molecule and non-modified and Zn-modified mesoporous materials, predicted by the quantum-chemical calculations. For the first time the formation of the most stable Zn quercetin complexes loaded on the mesoporous silica materials were determined. The obtained mesoporous delivery systems with Zn-quercetin complex are promising as dermal formulations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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show abstract

“…The modified clinoptilolite has been reported to exhibit antidiarrhetic [10], antacidic [11] and antiviral properties [12]. Also, it has been shown that natural clinoptilolite is a promising material for anticancer therapy [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of modified natural clinoptilolite against clinical isolates of Acinetobacter baumannii

Hrenović

Milenković

Goić-Barišić

et al. 2013

Microporous and Mesoporous Materials

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“…The tumor cell lines studied after the application of modified zeolite CTQ or CTQD had lower antiproliferative activity in comparison with the natural zeolite of the clinoptilolite-type CT. The modified zeolite CTQD had greater antiproliferative effects than modified zeolite CTQ [124].…”

Section: Organic/inorganic Hybrid Nanosystemsmentioning

confidence: 91%

Flavonoid Complexes as Promising Anticancer Metallodrugs

Uivaroşi¹,

Arbănași²

2017

Flavonoids - From Biosynthesis to Human Health

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Flavonoid metal complexes commonly exhibit an improvement of biological activity compared to the parent ligands. This chapter is focused on the antioxidant and anticanccer properties of flavonoid metal complexes, in correlation with their binding ability to vital macromolecules such as nucleic acids and serum proteins. Perspectives for an adequate formulation of these complexes were also discussed.

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Modified natural clinoptilolite with quercetin and quercetin dihydrate and the study of their anticancer activity

Cited by 27 publications

References 22 publications

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Antibacterial activity of modified natural clinoptilolite against clinical isolates of Acinetobacter baumannii

Flavonoid Complexes as Promising Anticancer Metallodrugs

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