Modified multivisceral transplantation without a liver graft for Gardner/Desmoid syndrome and chronic intestinal pseudo-obstruction

Multivisceral transplant is a viable treatment option for patients with non‐resectable intra‐abdominal fibromatosis

“…Recently, non‐resectable intra‐abdominal fibromatosis involving the mesenteric root has been indicated for MVT. However, given the complex natures of MVT and associated high risks, only a handful of studies have been published (Table ) . The first MVT for intra‐abdominal fibromatosis was reported by Misiakos et al in 1999 .…”

“…Multivisceral transplant (MVT), as the last straw, is a potential treatment for patients with non‐resectable fibromatosis that is beyond conventional surgery. Rare MVT cases have been reported, although the prognosis and predicators are largely unknown . This report aimed to study the survival and recurrence in a series of six patients who had conventionally non‐resectable fibromatosis and underwent MVT.…”

Intestinal transplantation for the treatment of neoplastic disease

“…Unfortunately attempt of surgical resection often carries high risk of large amount of bleeding and possibility of short bowel as a consequence of massive intestinal resection because of its anatomical location and biological behavior [24]. Autograft (partial eviscerectomy, ex vivo resection of the tumor, and re-implantation of the small intestine) or allograft abdominal [25][26][27][28][29]. In fact, desmoid tumor has been the most indicated neoplastic disease in abdominal organ cluster transplantation.…”

Current status of the organ replacement approach for malignancies and an overture for organ bioengineering and regenerative medicine

“…97 Since then, its shortterm outcomes have improved significantly and indications of either intestinal, liver-intestinal, or multivisceral (full/modified) transplantations 98 have expanded for a wide variety of tumors such as desmoid (Gardner's syndrome), neuroendocrine, adenocarcinoma, schwannoma, lymphoma, and sarcoma that would otherwise be unresectable. [99][100][101][102][103][104][105][106][107][108][109][110][111][112] Currently, there is no standardized indication of intestinal and multivisceral transplantation for neoplastic disease. However, for high-grade malignancies such as adenocarcinoma and lymphoma, the disappointing oncological results in the earlier series obviously warrant deliberate patient selection, if not contraindicated.…”