Modified McFadyen-Stevens Reaction for a Versatile Synthesis of Aromatic Aldehydes

Partial reductions of carboxylic acids and their derivatives to aldehydes

“…94 This method displays excellent chemoselectivity and allows the highly selective reduction of amides in the presence of other unsaturated groups such as alkenes, nitriles, esters, ketones, and even aldehydes. Different N,N-substituted amides (111) were well reduced. The reduction efficiency was closely affected by the electronic properties of the aromatic rings of aromatic amides and the steric environment of the α-position of aliphatic amides.…”

“…The synthetic practicability of this modified McFadyen-Stevens reaction was further emphasized by Shimokawa. 111…”