Modified lipidomic profile of cancer-associated small extracellular vesicles facilitates tumorigenic behaviours and contributes to disease progression

Fyfe, Jordan; Malhotra, Pratibha; Falasca, Marco

doi:10.1016/j.jbior.2022.100935

Cited by 1 publication

(2 citation statements)

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“…EV composition is determined largely by the type and physiological state of the producer cells ( 19 ). EVs show a similar lipid profile as the cell that produced them, including glycosphingolipid, phospholipid, and cholesterol composition ( 20 , 21 , 23 ). Proteins displayed on the surface of nearly all EVs include Alix, tetraspanins (CD9, CD63, and CD81), heat shock protein 70 ( 24 , 25 ), and other proteins that are often associated with specific EV subsets ( 24 , 26 , 27 ).…”

Section: Understanding Ev Tropism Based On Cellular Source and Releva...mentioning

confidence: 99%

“…Along with the potential for EVs to deliver therapeutic cargo, several engineering strategies have been reported for luminal loading or surface display of functional proteins or RNA. EVs can be engineered with known or screened cargo and enhance the therapeutic efficacy in disease models (18)(19)(20)(21). Here, we review cell and organ tropism of EVs depending on the source and cellular target, and engineering strategies for EV surface display for targeting delivery.…”

Section: Introductionmentioning

confidence: 99%

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Defining tropism and activity of natural and engineered extracellular vesicles

Choi,

Park,

Eliceiri

2024

Front. Immunol.

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Extracellular vesicles (EVs) have important roles as mediators of cell-to-cell communication, with physiological functions demonstrated in various in vivo models. Despite advances in our understanding of the biological function of EVs and their potential for use as therapeutics, there are limitations to the clinical approaches for which EVs would be effective. A primary determinant of the biodistribution of EVs is the profile of proteins and other factors on the surface of EVs that define the tropism of EVs in vivo. For example, proteins displayed on the surface of EVs can vary in composition by cell source of the EVs and the microenvironment into which EVs are delivered. In addition, interactions between EVs and recipient cells that determine uptake and endosomal escape in recipient cells affect overall systemic biodistribution. In this review, we discuss the contribution of the EV donor cell and the role of the microenvironment in determining EV tropism and thereby determining the uptake and biological activity of EVs.

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