Defining tropism and activity of natural and engineered extracellular vesicles
Wooil Choi,
Dong Jun Park,
Brian P. Eliceiri
Abstract:Extracellular vesicles (EVs) have important roles as mediators of cell-to-cell communication, with physiological functions demonstrated in various in vivo models. Despite advances in our understanding of the biological function of EVs and their potential for use as therapeutics, there are limitations to the clinical approaches for which EVs would be effective. A primary determinant of the biodistribution of EVs is the profile of proteins and other factors on the surface of EVs that define the tropism of EVs in… Show more
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