Modified halloysite nanoclay as a vehicle for sustained drug delivery

Abstract

This paper presents the effect of modified halloysite nanotubes on the sustained drug release mechanisms of sodium salicylate. Acid treatment and composite polymer-halloysite modification techniques were adopted in this study. After each modification, sodium salicylate drug was loaded, and in vitro release properties were evaluated and compared with the raw unmodified halloysite nanotubes. The results obtained from SEM, TEM and FTIR analyses indicate that both acid treatment and composite formation have no effect on the tubular structure and morphology of halloysite. However, modification of the halloysite nanotubes did influence the drug release rate. In the acid treatment modification, there was an improved loading of sodium salicylate drug which resulted in the sustain release of large amount of the sodium salicylate. In the polymer/halloysite composite formation, a consistent layer of polymer was formed around the halloysite during the composite formation and thus delayed release providing sustained release of sodium salicylate drug over a longer period of time as compared to the acid treated and unmodified halloysite. The results from the invitro release were best fitted with the Higuchi and the Koresymer-Peppas models.

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

“…Thus, the release of drugs from the lumen is mostly controlled by the diffusion of the drug molecule from the nanotube interior that is substantially retarded by the 1D nanotube structure. Thus, the release of analgesics (ibuprofen, 18 aspirin, 35 sodium salicylate 36 ) from bare HNTs obeys the Fickian diffusion model. Different modifications of the HNT lumen allow adjusting the affinity of the drug to the HNTs and therefore controlling the release rate.…”

Synthesis and Application of Fe-Doped TiO2-Halloysite Nanotubes Composite and Their Potential Application in Water Treatment

“…Halloysite nanotubes have high adsorption capacity and are biocompatible, relatively cheap, readily available, and nontoxic. ese unique properties of HNTs have enabled them to be used in different applications such as oil spill remediation, drug delivery systems, electronics, catalysis, water purification, and composite materials for construction [31][32][33][34][35]. Unlike the different adsorbent materials used in developing adsorbent-photocatalyst systems, naturally occurring HNTs are readily available and are low cost when compared with carbon nanotubes.…”

Optical and pH-Responsive Nanocomposite Film for Food Packaging Application

“…Similarly, natural indicators extracted from various plants have been used as non-toxic pH-indicators for preparing the colorimetric and optical pH-responsive films [7,8]. Incorporation of nanomaterials such as nanoclays as a reinforcing matrix enhance the mechanical properties, durability and biodegradability of the bionanocomposite [9,10].…”