Modified gum arabic cross-linked gelatin scaffold for biomedical applications

Sarika, P.R.; Cinthya, Kuriakose; Jayakrishnan, A.; Anilkumar, P.R.; James, Nirmala Rachel

doi:10.1016/j.msec.2014.06.042

Cited by 68 publications

(32 citation statements)

References 53 publications

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“…Nishi et al prepared oxidised GA and conjugated it with different drugs and evaluated its application in drug delivery [38][39][40]. The preparation, characterisation and in vitro biomedical applications of gum arabic aldehyde cross-linked gelatin hydrogels [41,42] have been reported by us recently. However, no research effort has been made to prepare GA based nanogels.…”

Section: Q2mentioning

confidence: 99%

“…The present work reports the application of a novel cross-linker, GAA for the preparation of gelatin nanoparticles. Cross-linking of gelatin with GAA, resulting in the formation of macroscopic hydrogels suitable for tissue engineering applications and as a packed bed matrix for hepatocyte perfusion culture is recently reported [41,42]. However, the possibility of using such biopolymer aldehydes for the preparation of gelatin nanoparticles by miniemulsion technique is yet to be reported.…”

Section: Preparation Of Gel-gaa Nanogelsmentioning

confidence: 99%

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Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Sarika

James

2015

International Journal of Biological Macromolecules

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Section: Q2mentioning

confidence: 99%

Section: Preparation Of Gel-gaa Nanogelsmentioning

confidence: 99%

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Sarika

James

2015

International Journal of Biological Macromolecules

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“…The ability of biopolymer extracted from fish scale to form uniform blend with cellulose particles can be attributed to the protein-polysaccharide intermolecular bonding due to the presence of the amide linkage in protein of the fish scale which is essentially hydrolysed collagen and the OH group of the cellulose polysaccharide. These forces allow good compatibility ion protein polysaccharide composites (8). Both DSC and FTIR studies are not conducted because the aim of this study was the lidocaine release from microneedle polymeric composite.…”

Section: Discussionmentioning

confidence: 99%

Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

et al. 2017

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Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2.5 to 7.5% w/w after 36 h and pseudo steady state profile is observed from 5.0 to 10.0% w/w lidocaine-loaded microneedle. Swelling experiments have suggested that the microneedles have negligible swellability which implies that the patch would stick to the tissue when inserted. The experiments on MN dissolution have depicted that the lidocaine loaded in the patch is lower than the theoretical loading, which is expected as there can be losses of the drug during initial process manufacture.

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“…31,32 Polysaccharides have long been recognized as an excellent degradable and biocompatible scaffold to use in biomedical applications. 33,34 The use of polysaccharide as a coating for HA/TTCP granules was proposed to improve the cohesion of granules. Moreover, the polysaccharide gel degrades with time, leaving empty surrounding spaces where cells may migrate as well as being released by gel allowing their participation to the formation of new bone.…”

Section: Discussionmentioning

confidence: 99%

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate

et al. 2015

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The purpose of this study was to examine the in vitro cytocompatibility of a novel injectable multiphasic bone substitute (MBS) based on polysaccharide gel-coated OSPROLIFE(®) hydroxyapatite (HA)/tetracalcium phosphate (TTCP) granules combined with bone marrow concentrate (BMC). Polysaccharide gel-coated granules loaded in syringe were combined with BMC diluted in ionic crosslinking solution. The product was then maintained in culture to investigate the cytocompatibility, distribution, and osteogenic differentiation function of cells contained in the BMC. The in vitro cytocompatibility was assessed after 0, 24, and 96 h from the injectable MBS preparation using the LIVE/DEAD(®) staining kit. The results highlighted that cells remained viable after combination with the polysaccharide gel-coated granules; also, viability was maintained over time. The distribution of the cells in the product, observed using confocal microscopy, showed viable cells immersed in the polysaccharide gel formed between the granules after ionic crosslinking. The mesenchymal stromal cells (MSC) contained in the injectable MBS, the basic elements for bone tissue regeneration, were able to differentiate toward osteoblasts, producing an osteogenic matrix as evidenced by alizarin red-s (AR-S) staining. In conclusion, we found that the injectable MBS may have the potential to be used as a bone substitute by applying a "one-step" procedure in bone tissue engineering applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 894-902, 2016.

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Modified gum arabic cross-linked gelatin scaffold for biomedical applications

Cited by 68 publications

References 53 publications

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate

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Modified gum arabic cross-linked gelatin scaffold for biomedical applications

Cited by 68 publications

References 53 publications

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE® HA/TTCP granules and bone marrow concentrate

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Product

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Characterization and cytocompatibility of a new injectable multiphasic bone substitute based on a combination of polysaccharide gel‐coated OSPROLIFE^® HA/TTCP granules and bone marrow concentrate