Modified gold surfaces by 6-(ferrocenyl)hexanethiol/dendrimer/gold nanoparticles as a platform for the mediated biosensing applications

Karadag, Murat; Geyik, Caner; Demirkol, Dilek Odaci; Ertaş, F. Nil; Tımur, Suna

doi:10.1016/j.msec.2012.10.008

Cited by 39 publications

(23 citation statements)

References 40 publications

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“…Rely on their large numbers of terminal functional groups, PAMAM can greatly increase the quantity of attached various biomolecules such as antibody, enzyme, or aptamer, and consequently improve sensitivity of detection (Akter, Jeong, Lee, Choi, & Rahman, 2017;Malvano, Albanese, Pilloton, & Matteo, 2017;Miodek, Omrani, Khoder, & Youssoufi, 2016). Meanwhile, it was also extensively applied in electrochemical sensor in order to additionally amplify the sensitivity and reach a low detection limit through association with others conductive nanomaterials such as AuNPs, Ag nanoparticles, grapheme, and so on (Araque et al, 2014;Karadag, Geyik, Demirkol, Ertas, & Timur, 2013;Ning, Zhang, & Zheng, 2014). However, to the best of our knowledge, it has rarely been used as a sensitization medium in lateral flow strip for the signal-enhancement process (Shen, Xu, Gurung, Yang, & Liu, 2013).…”

Section: Introductionmentioning

confidence: 99%

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Peng

Kang

Pang

et al. 2017

Food and Agricultural Immunology

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A signal-enhanced lateral flow strip biosensor has been constructed for ultrasensitive and on-site visual detection of bisphenol A (BPA). The signal amplification principle is based on the capacity of binding a large number of antibody-assembled gold nanoparticle (AuNP-antibody) conjugates of the poly amidoamine (PAMAM), which bears a multitude of amino groups. This signal-enhanced method could achieve BPA detection at 10 ppb based on naked eye visual observation, which represents an at least 50-fold improvement of the sensitivity of a traditional method without PAMAM. Moreover, good linearity was observed in the range from 2 to 100 ppb after quantitative analysis using the ImageJ software. This signal amplification method could be adopted as a potential generous technique in different fields. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Peng

Kang

Pang

et al. 2017

Food and Agricultural Immunology

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“…Table 2 summarizes the comparison of the analytical characteristics ofSNS-NH 2 /SNS-NH 2 -Fc/GOx biosensor with others reported in literature. According to the working conditions such as type of reference and working electrode, enzyme active centre, enzyme immobilization technique and whether bound or unbound of mediator, the applied potential to obtain biosensor response in second generation amperometric biosensors which use Fc as a mediator can be varied [ 20 , 21 , 33 – 35 ]. In our case, it can be said that the interaction of Fcon the polymer surface with the active center of the enzyme could be performed efficiently and followed properly at the applied potential of +0.45 V/Ag/AgCl.…”

Section: Resultsmentioning

confidence: 99%

“…Then Karadag et al reported an electrochemical biosensor mediated by using 6-(ferrocenyl)hexanethiol (FcSH) by construction of gold nanoparticles on the surface of polyamidoamine dendrimer (PAMAM)-modified gold electrode. GOx was used as a model enzyme and immobilized onto the gold surface, forming a self-assembled monolayer via FcSH and cysteamine [ 21 ]. Another glucose biosensor was fabricated based on a chitosan-bovine serum albumin cryogel with multiwalled carbon nanotubes (MWCNTs), Fc, and GOx [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors

Ayrancı

Demirkol

et al. 2015

Sensors

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Herein, we report a novel ferrocenyldithiophosphonate functional conducting polymer and its use as an immobilization matrix in amperometric biosensor applications. Initially, 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)amidoferrocenyldithiophosphonate was synthesized and copolymerized with 4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzenamine at graphite electrodes. The amino groups on the polymer were utilized for covalent attachment of the enzyme glucose oxidase. Besides, ferrocene on the backbone was used as a redox mediator during the electrochemical measurements. Prior to the analytical characterization, optimization studies were carried out. The changes in current signals at +0.45 V were proportional to glucose concentration from 0.5 to 5.0 mM. Finally, the resulting biosensor was applied for glucose analysis in real samples and the data were compared with the spectrophotometric Trinder method.

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“…The well‐established redox properties of ferrocenyl dendrimers have been used in the construction of electrochemical biosensors for molecular recognition . Generally, the presence of guest molecules in close proximity to the ferrocenyl groups can cause a significant change in their redox potential.…”

Section: Dendrimer‐based Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

et al. 2017

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The use of biosensors in point‐of‐care (POC) testing devices has attracted considerable attention in the past few years, mainly because of their high specificity, portability, and relatively low cost. Coupling these devices with miniaturized electrochemical transducers has shown great potential toward simple, rapid, and cost‐effective analysis that can be performed in the field, especially for healthcare, environmental monitoring, and food quality control. For this reason, the number of publications in this field has grown exponentially over the past decade, making it a trending topic in current research. Although great improvement has been achieved in the field of electrochemical biosensing, there are still some challenges to overcome, especially concerning the improvement of sensing materials and miniaturization. In this Review, we summarize some of the most recent advances achieved in POC electrochemical biosensor applications, focusing on new materials and modifiers for biorecognition developed to improve sensitivity, specificity, stability, and response time.

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Modified gold surfaces by 6-(ferrocenyl)hexanethiol/dendrimer/gold nanoparticles as a platform for the mediated biosensing applications

Cited by 39 publications

References 40 publications

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

A signal-enhanced lateral flow strip biosensor for ultrasensitive and on-site detection of bisphenol A

Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

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