Breast cancer remains the most commonly diagnosed cancer in women in the United States. 1 Surgical options include breast conservation surgery or mastectomy, with similar survival rates. 2,3 Patients who undergo mastectomy can subsequently decide to pursue immediate or delayed breast reconstruction. Postoperative complications of these procedures remain a major concern and lead to significant morbidity, including surgical site infection, skin flap necrosis, loss of implant, and need for reoperation. Complications can result in prolonged hospital stays, increased costs, and the delay of adjuvant therapy. 4 It is important to identify risk factors for post-mastectomy complications to provide adequate counseling and mitigate risk.Several predictors of surgical outcomes have been analyzed, including body mass index (BMI), smoking status, age, and medical comorbidities. More recently, the concept of frailty was introduced as a surrogate for physiologic age, with the goal of developing a more accurate predictor. Frailty is defined as a generalized, aging-related clinical state in which there is a diminished physiological reserve and function and an increased vulnerability to stressors, including surgery. 5 Frailty has been shown to be strongly associated with adverse outcomes, including postoperative complications, mortality,