Delirium and frailty are prevalent geriatric syndromes and significant public health issues among older adults. The prevalence of delirium among hospitalized older adults can be from 15% to 75%, and the prevalence of frailty ranges between 12% and 24%. The exact pathophysiology of these two conditions is not clearly identified, and there are several hypotheses. But it is thought that they are multifactorial in their etiology and are associated with inflammation related to aging, alteration of vascular systems, genetics, and nutritional deficiency. Furthermore, clinically, they are significantly associated, that frailty increases the risk of delirium almost 2~3 times among hospitalized older adults. With their multifactorial etiology and unknown pathophysiology, the current evidence supports a more practical multicomponent patient-centered approach to prevent and manage delirium among hospitalized older adults. Such a comprehensive and organized bundled approach can identify high-risk patients with frailty and manage delirium more effectively.