Modified electroconvulsive therapy for the treatment of refractory schizophrenia-like psychosis associated with Huntington’s disease

Nakano, Takeshi; Ono, Shinji; Yamaguchi, Junji; Sugimoto, Ryu; Yamaguchi, Naohiro; Morimoto, Yoshiro; Kubo, Tatsuya; Ozawa, Hiroki; Kurotaki, Naohiro

doi:10.1007/s00415-012-6720-2

Cited by 12 publications

(21 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for psychotic disorders, the five cases reported in the literature 8 show positive results of ECT. ECT was effective and well tolerated in 13 of 14 cases.…”

Section: Discussionmentioning

confidence: 92%

Differential Response to ECT of Psychotic and Affective Symptoms in Huntington’s Disease: A Case Report

Petit¹,

Hozer²,

Youssov³

et al. 2016

JNP

View full text Add to dashboard Cite

“…As for psychotic disorders, the five cases reported in the literature 8 show positive results of ECT. ECT was effective and well tolerated in 13 of 14 cases.…”

Section: Discussionmentioning

confidence: 92%

Differential Response to ECT of Psychotic and Affective Symptoms in Huntington’s Disease: A Case Report

Petit¹,

Hozer²,

Youssov³

et al. 2016

JNP

View full text Add to dashboard Cite

“…Psychiatric intervention and support are particularly useful in the case of psychotic disorders occurring in HD, for treatment adjustments. If pharmacological treatments fail, the option of ECT can be discussed with psychiatrists (Grade C) (71, 73, 107).…”

Section: Resultsmentioning

confidence: 99%

International Guidelines for the Treatment of Huntington's Disease

et al. 2019

View full text Add to dashboard Cite

The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice for treatment of Huntington's disease (HD). The objectives of such guidelines are to standardize pharmacological, surgical and non-pharmacological treatment regimen and improve care and quality of life of patients. A formalized consensus method, adapted from the French Health Authority recommendations was used. First, national committees (French and English Experts) reviewed all studies published between 1965 and 2015 included dealing with HD symptoms classified in motor, cognitive, psychiatric, and somatic categories. Quality grades were attributed to these studies based on levels of scientific evidence. Provisional recommendations were formulated based on the strength and the accumulation of scientific evidence available. When evidence was not available, recommendations were framed based on professional agreement. A European Steering committee supervised the writing of the final recommendations through a consensus process involving two rounds of online questionnaire completion with international multidisciplinary HD health professionals. Patients' associations were invited to review the guidelines including the HD symptoms. Two hundred and nineteen statements were retained in the final guidelines. We suggest to use this adapted method associating evidence base–medicine and expert consensus to other rare diseases.

show abstract

“…Many of the referrals for depression alone were from some of the earliest reports, which lacked a clear description of the referral characteristics. 6,7 The remainder of patients had numerous coexisting factors such as paranoia, delusions and other manifestations of psychosis, including hallucinations 1,2,4,5,[8][9][10][11] . Coexistent motor symptoms were present in 20 patients [1][2][3]5,9,10,[12][13][14][15] (including our case), with chorea being the most commonly used term.…”

Section: Resultsmentioning

confidence: 99%

“…When coexistent disease such as depression was considered, 12 patients in total had prominent psychosis, and all responded to varying degrees, including our case. 1,5,9,10 Merida-Puga et al reported refractory psychosis thought to be due to use of depot dopamine antagonists, although the focus of their treatment was the refractory catatonia. 4 Hallucinations, either auditory (three cases including our case), 1,11,13 visual (two cases) 2,10 or both visual and auditory (two cases), 4,8 also responded well to treatment.…”

Section: Effects On Psychiatric Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Electroconvulsive therapy for severe depression, psychosis and chorea in a patient with Huntington's disease: case report and review of the literature

Mowafi

MILLARD

2020

BJPsych Bull

View full text Add to dashboard Cite

Aims and method The psychiatric manifestations of Huntington's disease are myriad and difficult to control. The use of electroconvulsive therapy (ECT) is not commonly considered for this condition. We describe a patient with severe depression, psychomotor retardation, delusions and weight loss who responded to ECT with good control of her symptoms. Results Both our case and the literature appear to confirm the efficacy of ECT in the treatment of depression in Huntington's disease and suggest that other psychiatric manifestations of Huntington's are also responsive. Clinical implications ECT is an effective and safe treatment that should be considered earlier in the course of the disease in cases that show limited response to pharmacological therapy. It should also be considered as an adjunct to medical therapy that may simplify polypharmacy and allow better control in patients with debilitating psychiatric manifestations of the disease. There is limited and conflicting evidence for its efficacy in chorea.

show abstract

Modified electroconvulsive therapy for the treatment of refractory schizophrenia-like psychosis associated with Huntington’s disease

Cited by 12 publications

References 9 publications

Differential Response to ECT of Psychotic and Affective Symptoms in Huntington’s Disease: A Case Report

Differential Response to ECT of Psychotic and Affective Symptoms in Huntington’s Disease: A Case Report

International Guidelines for the Treatment of Huntington's Disease

Electroconvulsive therapy for severe depression, psychosis and chorea in a patient with Huntington's disease: case report and review of the literature

Contact Info

Product

Resources

About