Modified Dioscorea hispida starch-based hydrogels and their in-vitro cytotoxicity study on small intestine cell line (FHS-74 Int)

Ashri, Airul; Amalina, Nurul; Kamil, Akhsan; Fazry, Shazrul; Sairi, Fareed; Nazar, Muhammad Faizan; Lazim, Azwan Mat

doi:10.1016/j.ijbiomac.2017.10.125

Cited by 20 publications

(8 citation statements)

References 33 publications

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“…11, the pore structure of the hydrogel depends on the ratios of starch, acrylic acid, and MBA. 48-h cell culture on 2 mg/L extract of the hydrogel demonstrated 100% viability [412].…”

Section: Starch-based Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Status and future scope of plant-based green hydrogels in biomedical engineering

Mohammadinejad

Maleki

Larrañeta

et al. 2019

Applied Materials Today

183

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Hydrogels are the most iconic class of soft materials and since their first report in the literature has attracted the attention of uncountable researchers. Over the past two decades, hydrogels become smart and sophisticated materials with plenty of applications possibilities. The biomedical research area has demonstrated a particular interest in hydrogels since they can be engineered from different polymers and due to their tunable properties. Moreover, hydrogels engineered from polymers extracted from biorenewable sources have been popularized in biomedical usages, as they are low-toxic, eco-friendly, biocompatible, easily accessible, and inexpensive at the same time. However, the multifaceted challenge is to find an ideal plant green hydrogel in the tissue engineering that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, these natural polymers are also idealized to be conveniently functionalized so that their chemical and physical behaviour can be manipulated for drug delivery and stem cell-guided tissue regeneration. Here, the most recent advances in the synthesis, fabrication and application of plant green hydrogels in biomedical engineering are reviewed. It covers essential and updated information about plant as green sources of biopolymers to be used in hydrogel synthesis, general aspects of hydrogels and plant green hydrogels and a substantive discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review addresses and detail the present status of the field and, also, answer several important questions about the potential use of plant green hydrogels in advanced biomedical applications including therapeutic, tissue engineering, wound dressing, diagnostic, etc.

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“…11, the pore structure of the hydrogel depends on the ratios of starch, acrylic acid, and MBA. 48-h cell culture on 2 mg/L extract of the hydrogel demonstrated 100% viability [412].…”

Section: Starch-based Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Status and future scope of plant-based green hydrogels in biomedical engineering

Mohammadinejad

Maleki

Larrañeta

et al. 2019

Applied Materials Today

183

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“…The swelling ratio (SR) of the SC was measured as previously described . The SC was immersed in deionized water at room temperature for 2 days until equilibrium was reached in terms of swelling.…”

Section: Methodsmentioning

confidence: 99%

“…The swelling ratio (SR) of the SC was measured as previously described. 22 The SC was immersed in deionized water at room temperature for 2 days until equilibrium was reached in terms of swelling. After absorbing excess water on the surface with filter paper, the swollen SC was immediately weighed (W s ).…”

Section: Hydrogel Characterizationmentioning

confidence: 99%

An in situ hydrogel based on carboxymethyl chitosan and sodium alginate dialdehyde for corneal wound healing after alkali burn

Liu

et al. 2018

J Biomedical Materials Res

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There is currently no optimal scaffold for the transplantation of limbal stem cells (LSCs) to induce corneal reconstruction after corneal alkali burns. This study attempts to fabricate a novel in situ Alginate‐Chitosan hydrogel (ACH) for LSCs transplantation. Sodium alginate dialdehyde (SAD), a biological crosslinker, was prepared by periodate‐mediated sodium alginate oxidization. Carboxymethyl chitosan was rapidly crosslinked with SAD via Schiff's base formation between the available aldehyde and amino groups. The ACH is rapidly formed on the wound surface by self‐crosslinking without adding any chemical crosslinking component. Gelation time, transmittance, microscopic structure, equilibrium swelling, cytotoxicity, histocompatibility and degradability of the hydrogel were all examined. Rabbit primary LSCs were encapsulated in the hydrogel and transplanted to alkali burn wounds in vivo . Cornea reconstruction was evaluated by visual observation, slit lamp, histological analysis, and immunofluorescence staining. Results showed that the in situ hydrogel was highly transparent, gelated quickly, biocompatible, and had low cytotoxicity. LSCs cultured in vitro expressed the stem marker p63 but lacked the differentiated epithelial markers cytokeratin 3 and 12. Furthermore, the hydrogel encapsulating LSCs could be formed quickly on the alkali burn wound of the cornea and was shown to significantly improve epithelial reconstruction. Taken together, treatment with this novel in situ hydrogel‐mediated LSC transplantation system may serve as a rapid and effective method for corneal wound healing. © 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 742–754, 2019.

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“…Determination of Digestion Resistibility in SGF, SIF, and SCF. 22 2.2.11.1. Gastric Phase (SGF, pH 1.2).…”

Section: Determination Of Paste Claritymentioning

confidence: 99%

Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

Bhatt

Kumar

Rastogi³

et al. 2023

ACS Omega

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The functional and tableting properties of barnyard millet starch (Echinochloa esculenta) were investigated in its native (alkali-treated) and chemically modified (phosphorylated) states. The grains were pulverized, soaked, and ground before filtration to separate starch and protein. Multiple NaOH treatments were performed. The starch was washed, neutralized, and dried. Sodium tripolyphosphate (STPP) and sodium sulfate were used to modify the starch, followed by maceration, washing, and drying to remove unreacted chemicals. The amylose content of alkali-treated barnyard millet starch increased by 19.96 ± 3.56% w/w. The amount of protein, the kind of starch used, and the size of the starch granules, all affected the ability of the starch granules to swell up. It was observed that alkali-extracted barnyard millet starch (AZS) has a swelling power of 194.3 ± 0.0064% w/w. The swelling capacity of treated starch was lesser as compared to the native alkali barnyard millet starch. Decrement in swelling power of phosphorylated starch was observed due to tightening of bonds in the molecular structure. The moisture content of the excipients may affect the overall stability of the formulation. The moisture content of the AZS was found to be 15.336 ± 1.012% w/w. Compared to AZS, cross-linked barnyard millet starch had a moisture content that was up to 20% lower than AZS. The Hausner ratio for phosphorylated starch was found to be 1.25, which indicates marked flow property. Similar morphologies could be seen in the alkali-isolated barnyard millet starch and the cross-linked/phosphorylated barnyard millet that was cross-linked using a mixture of sodium sulfate and sodium tripolyphosphate. The modest degree of substitution would have no effect on the surface morphology as shown by the scanning electron microscopic study. The crushing and compacting abilities of modified barnyard millet starch were also improved, but its friability and rate of disintegration were decreased. The whole study revealed that after cross-linking, barnyard millet had good tableting properties and it can be used as an excipient in drug delivery.

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Modified Dioscorea hispida starch-based hydrogels and their in-vitro cytotoxicity study on small intestine cell line (FHS-74 Int)

Cited by 20 publications

References 33 publications

Status and future scope of plant-based green hydrogels in biomedical engineering

Status and future scope of plant-based green hydrogels in biomedical engineering

An in situ hydrogel based on carboxymethyl chitosan and sodium alginate dialdehyde for corneal wound healing after alkali burn

Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

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