This research is about a new approach, which is used for optimizing multipliers designs, which are based on the concept of Vedic mathematics. The design has been targeted to to FPGAs (state-of-the art field-programmable gate arrays). It has been assessed that the multiplier produces partial products by utilizing Vedic mathematics concept by deploying basic 4 × 4 multipliers, which is designed by exploiting special features of multiplexers and 6-input look up tables (LUTs) on the same slices, resulting in considerable minimization in area. The multiplier has been realized on Xilinx® Virtex-5 FPGAs. It is significant to notice that pipeline adders were used to obtain final products. Furthermore, the multiplier is developed and organized by using pipeline schemes, which contribute to the enhancement of operating frequency of the multiplier. The results show that the 32-bit pipeline multiplier can work up to a clock frequency of 450 MHz. It has utilized 514 slices and 1157 flip-flops and has much less dynamic power than the other reported work.