Modifications of dietary flavonoids towards improved bioactivity: An update on structure–activity relationship

Abstract

Over the past two decades, extensive studies have revealed that inflammation represents a major risk factor for various human diseases. Chronic inflammatory responses predispose to pathological progression of chronic illnesses featured with penetration of inflammatory cells, dysregulation of cellular signaling, excessive generation of cytokines, and loss of barrier function. Hence, the suppression of inflammation has the potential to delay, prevent, and to treat chronic diseases. Flavonoids, which are widely distributed in humans daily diet, such as vegetables, fruits, tea and cocoa, among others, are considered as bioactive compounds with anti-inflammatory potential. Modification of flavonoids including hydroxylation, o-methylation, and glycosylation, can alter their metabolic features and affect mechanisms of inflammation. Structure-activity relationships among naturally occurred flavonoids hence provide us with a preliminary insight into their anti-inflammatory potential, not only attributing to the antioxidant capacity, but also to modulate inflammatory mediators. The present review summarizes current knowledge and underlies mechanisms of anti-inflammatory activities of dietary flavonoids and their influences involved in the development of various inflammatory-related chronic diseases. In addition, the established structure-activity relationships of phenolic compounds in this review may give an insight for the screening of new anti-inflammatory agents from dietary materials.

Phytochemicals from fern species: potential for medicine applications

“…Many flavonoids, especially flavonols, have been isolated from ferns and characterized (Harborne and Williams 1988;Cao et al 2013a, b). Flavonoids are abundant in Pteris species, and epidemiological and medical data suggest that they play key roles in preventing and managing diseases Xiao and Kai 2012;Xia et al 2014;Xiao et al 2016;Chen et al 2017;Xiao 2016c). Flavonoids from 20 fern species belonging to the genus Pteris have been studied (Gong et al 2007;Chen et al 2007).…”

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

“…Anthocyanins are hydrophilic and water-soluble polyphenolic plant pigments and metabolites, which are one of the important antioxidants. They possess a wide range of pharmacological properties, such as antioxidant, antiaging, anti-inflammatory, antimicrobial and anti-cancer [1][2][3][4].…”

The modulatory effect and the mechanism of flavonoids on obesity

“…Quercetin 3‐ O ‐galactopyranoside, quercetin 3‐ O ‐rhamnopyranoside, quercetin 3‐ O ‐arabinopyranoside and myrisetin 3‐ O ‐glucoside were also confirmed as potential anti‐inflammatory agents (Mothana et al, ). In addition, orientin with 8‐ C‐ glucoside have been proved to possess a higher anti‐inflammatory capacity than isoorientin with 6‐ C ‐glucoside both in vitro and in vivo (Chen et al, ).…”