Modifications of Au Nanoparticle-Functionalized Graphene for Sensitive Detection of Sulfanilamide

Abstract

In this paper, we present a simple and feasible electrochemical sensor based on Au nanoparticle-functionalized graphene for the determination of sulfanilamide. Au nanoparticles were deposited on graphene, which acted as a platform to prepare excellent nanocomposites. Attributed to the graphene’s large surface area and the Au nanoparticles’ strong conductivity, many sulfanilamide molecules were enriched on the sensor surface and the signal response became more sensitive. Under the optimal conditions, the electrochemical sensors could be used for the efficient detection of sulfanilamide. Good linearity was observed in the range of 0.1–1000 μmol·L−1 and the detection limit was 0.011 μmol·L−1. Most importantly, the Au nanoparticle-functionalized graphene-modified electrode could be successfully applied for the detection of sulfanilamide in animal meat, and exhibited good stability, acceptable recovery, and offered a promising platform for point-of-care detecting in real samples.

Specific Chemical Modification of Nanohole Edges in Membrane Graphene for Protein Binding

“…1 In this case, some of the graphene properties that might affect the detection limit must be considered. 35 The preparation methods of graphene and its derivatives could be tailored to induce a variety of properties to make the graphene suitable for specific applications, such as sensing; 2,30,32,36 in addition, the chemical modifications of the graphene oxide (GO) or reduced graphene oxide (rGO) surfaces can result in new functional groups that make the surfaces specific for different types of targets. Other essential parameters can play significant roles in the sensitivity and selectivity of graphene, such as the number of layers, the binding process between the graphene layer and the bioreceptor, and the number of functional groups on the surface, which significantly control the limit of detection of the target molecules.…”

“…Furthermore, graphene, combined with nanomaterials, e.g., metal nanoparticles, has been investigated as a biosensor . In this case, some of the graphene properties that might affect the detection limit must be considered …”