Modification of the surface properties of a lens material to influence posterior capsular opacification

Abstract

Posterior capsular opacification is a form of wound healing and the behaviour of lens epithelial cells is central to its progression. Emphasis has been on the elimination of residual lens epithelial cells to combat PCO. This study demonstrated that the phenotype of BLECs was influenced by the surface properties of the intraocular lens materials. Gas plasma treatment of the materials increased their hydrophilicity and allowed the adhered BLECs to maintain their normal epithelial morphology. We believe that controlled growth of lens epithelial cells may reduce the incidence of PCO.

Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology

“…Over the past three decades, various techniques such as plasma processing [3,4], chemical grafting [5], and ion implantation [6] have been applied to the surface modification of PMMA IOL. Among these approaches, plasma-induced graft polymerization is an attractive way for modifying the surface chemistry and morphology of polymeric materials at low temperatures [7][8][9][10].…”

Evaluations of Shorter Exposures of Contact Lens Cleaning Solutions against Fusarium oxysporum Species Complex and Fusarium solani Species Complex To Simulate Inappropriate Usage

“…An insight into this observed phenomenon has been provided in studies by Ahearn and colleagues, who reported that F. oxysporum strains showed greater penetration of contact lenses and survived better after treatment with MPS, while F. solani strains were easily removed (2,35). However, these experimental findings must be reconciled with clinical studies, where other institutions have reported more FSSC in their keratitis patients (3,16,32) Clearly, in vitro experiments are limited in simulating all of the conditions that predispose patients to Fusarium keratitis.…”

Grafting CVD of Poly(vinyl pyrrolidone) for Durable Scleral Lens Coatings

“…[1][2][3]5,6] A plasma treatment to the lenses improved the condition minimally, and likewise has been shown on traditional contact and intraocular lenses to do the same. [7] To further enhance the efficacy of the lens, the work outlined in this paper will explore adding hydrophilic coatings to the exterior of the lens by CVD. CVD thin films are of interest since they are not limited to growth on flat substrates or on particular substrate materials.…”