Modification of the Rat Alloimmune Response by Enhancing Antibodies and the Role of Blocking Factors in the Survival of Renal Grafts

Tb, Strom; Cb, Carpenter; Mr, Garovoy; Ak, Abbas; Jm, Corson; Ra, Bear; Jp, Soulillou

doi:10.1097/00007890-197511000-00003

Cited by 23 publications

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“…Secondly, the PAS and RAS could contain antireceptor antibodies, Lewis anti(Lew anti-BN), which have been detected in some HIS that produce enhancement (25). Such anti-idiotypic antibodies have been re-ported in sera obtained after hyperimmunization procedures (26); however, the HIS we have used lack such a factor (6).…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, Ia antigens are present on passenger leukocytes (31,32) and possibly on endothelium of the graft. Secondly, the most important functional alteration of the enhanced host appears to be abrogation of its capacity to produce IgG-mediated lesions in the graft (6, 7), rather than the comparatively minor alterations of cell-mediated immunity (6,33). This alteration of the humoral immune response of the host closely mimics the impaired IgG response seen when T-B collaboration is lacking during the induction phase of immunity (34).…”

Section: Discussionmentioning

confidence: 99%

“…The phenomenon of passive enhancement of tumor and tissue allografts (1,5) has been shown to be associated with only minimal alteration in cellular immune responsiveness in the host (6). In contrast, immunopathological (7,8) and humoral studies (6)(7)(8)(9) have emphasized the depression of host humoral responsiveness and suggest an impairment of B-T-cell cooperation (6).…”

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confidence: 99%

“…In contrast, immunopathological (7,8) and humoral studies (6)(7)(8)(9) have emphasized the depression of host humoral responsiveness and suggest an impairment of B-T-cell cooperation (6). Still, the mechanism by which passive immunization produces this deviation in the immune response remains speculative.…”

mentioning

confidence: 99%

“…An important recent advance has been the finding that, while antibodies of different classes (10) and physicochemical characteristics (11) can induce enhanced graft survival, antibodies specific for the products of the K and D regions of the mouse MHC are unnecessary (12). Similarly, in the rat, the recipients, as previously described (6,17). Animals in experimental groups received intravenous injections of a particular hyperimmune serum (HIS), Lewis anti-BN, immediately after transplantation, whereas control rats received no therapy.…”

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The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

Soulillou¹,

Carpenter²,

d’Apice³

et al. 1976

The Journal of Experimental Medicine

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The ready availability of inbred strains, ability to withstand microvascular surgery, and the ease of production of immunological enhancement have made the rat a popular and valuable model for organ transplantation. A number of studies in the mouse employing skin allografts have demonstrated the central role of gene products of the major histocompatibility H-2 complex in the rejection process. Fragmentary understanding of the rat major histocompatibility gene complex (MHC) 1 has limited the general applicability of data obtained by studying rat organ transplantation. Because important differences exist between the immunobiology of skin and organ allografts (1), it is important to develop a full understanding of the rat MHC. Recent studies have indicated that rat gene products identical to or closely linked to the serologically defined Ag-B system function as immune response genes (2, 3) and stimulate the mixed lymphocyte culture response (4). These studies suggest, therefore, that the rat MHC bears close similarity to the more extensively mapped MHC regions of primates and the mouse.The phenomenon of passive enhancement of tumor and tissue allografts (1, 5) has been shown to be associated with only minimal alteration in cellular immune responsiveness in the host (6). In contrast, immunopathological (7,8) and humoral studies (6-9) have emphasized the depression of host humoral responsiveness and suggest an impairment of B-T-cell cooperation (6). Still, the mechanism by which passive immunization produces this deviation in the immune response remains speculative. An important recent advance has been the finding that, while antibodies of different classes (10) and physicochemical characteristics (11) can induce enhanced graft survival, antibodies specific for the products of the K and D regions of the mouse MHC are unnecessary (12). Similarly, in the rat,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

Soulillou¹,

Carpenter²,

d’Apice³

et al. 1976

The Journal of Experimental Medicine

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Successful cardiac allografts in syngeneic radiation chimeras

Dittmer

Bennett

1978

Mol Cell Biochem

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Successful cardiac allografts were accomplished across the major histocompatibility complex of rats. LEW and F344 (Ag-B2) rats were lethally irradiated and grafted with WF (Ag-B1) hearts on day 0. Either on day 0 or day 2, the hosts were repopulated with syngeneic hemopoietic cells. The best results were obtained (86%) when a mixture of 3.0 x10(7) non-adherent syngeneic bone marrow and thymus cells were used to repopulate the recipients. In contrast, all of the WF to LEW heart grafts were rejected within 30 days if syngeneic thoracic duct and bone marrow cells were used to repopulate the host. Tolerant rats bearing a functioning WF heart graft were able to mount a normal antibody response to SRBC and a proliferative response to Con A. They accepted a second WF heart or a WF kidney graft but rejected WF skin and bone marrow grafts as well as "third-party" ACl or BN hearts. The lymphocytes of tolerant rats had a reduced response to WF antigens as assayed by local or systemic graft-versus-host reactions in (LEW x WF)F1 recipients. Tolerance to the WF hearts was resistant to a large innoculum of normal spleen and lymph node cells. The unresponsive state could be transferred to unirradiated LEW rats with a mixture of spleen, thymus, lymph node and bone marrow cells.

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Die allogene Lebertransplantation

Bockhorn

1981

Res. Exp. Med.

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Although pig liver allograft induces a regular cellular immune response the transplanted live shows only mild injection or can be accepted. Long term survivors show a reduced cellular immunity in vitro involving the lack of donor-specific memory cells and the development of blocking antibodies. These immunoglobins are mainly considered to mediate the increased survival time of the grafted liver. They show anti-Ia-like specificities and their induction is favoured by the particular Ia- and SD-antigen pattern of the liver tissue. The immunological status observed in liver-allografted pigs is comparable to the active enhancement. In terms of morphological, functional and immunological changes the clinical liver transplantation shows striking similarities to the experimental animal model with pigs. The predominant, non-immunological complications could be overcome in the past few years so that the one-year survival rate was increased to 50%. The good survival rate and the low rejection risk due to the immunological peculiarity of the liver seem to justify the clinical application of the liver transplantation in cases of severe liver disorders which cannot be treated by conventional clinical methods.

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Modification of the Rat Alloimmune Response by Enhancing Antibodies and the Role of Blocking Factors in the Survival of Renal Grafts

Cited by 23 publications

References 0 publications

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.

Successful cardiac allografts in syngeneic radiation chimeras

Die allogene Lebertransplantation

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