Die allogene Lebertransplantation

Abstract

Although pig liver allograft induces a regular cellular immune response the transplanted live shows only mild injection or can be accepted. Long term survivors show a reduced cellular immunity in vitro involving the lack of donor-specific memory cells and the development of blocking antibodies. These immunoglobins are mainly considered to mediate the increased survival time of the grafted liver. They show anti-Ia-like specificities and their induction is favoured by the particular Ia- and SD-antigen pattern of the liver tissue. The immunological status observed in liver-allografted pigs is comparable to the active enhancement. In terms of morphological, functional and immunological changes the clinical liver transplantation shows striking similarities to the experimental animal model with pigs. The predominant, non-immunological complications could be overcome in the past few years so that the one-year survival rate was increased to 50%. The good survival rate and the low rejection risk due to the immunological peculiarity of the liver seem to justify the clinical application of the liver transplantation in cases of severe liver disorders which cannot be treated by conventional clinical methods.

Serial Mixed Lymphocyte Culture Responses in Pigs after Liver or Kidney Auto- or Allotransplantation

“…Bom van Noordloos et al [18], Vaiman et al [19], Flye et al [20], and Bockhorn [21] have shown a dependence on the strain combina tion and SLA compatibility, which has been confirmed in the rat by Zimmerman et al [22] and Tsuchimoto et al [23], However, our own previous experience [7], and the present data accord with that of Caine et al [24], and shows that up to 60% unimmunosuppressed pigs survive despite highly stimu latory MLC responses between donor and recipient pre-operatively. This is also borne out by the fact that the occurrence of rejec tion in human liver allografts appears unre lated to the lymphocyte crossmatch or to MHC mismatch [25,26].…”