Modification of Spherical Polyelectrolyte Brushes by Layer-by-Layer Self-Assembly as Observed by Small Angle X-ray Scattering

Tian, Yanhua; Li, Li; Han, Haoya; Wang, Yunwei; Ye, Zhishuang; Guo, Xuhong

doi:10.3390/polym8040145

Cited by 16 publications

(22 citation statements)

References 54 publications

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“…The data analysis in this work was done as described in the literatures . The scattering intensity, I ( q ), can be expressed as a function of the scattering vector q which is determined according to the following equation:

q = ((), \frac{4 π}{λ}) sin ((), \frac{θ}{2})

…”

Section: Methodsmentioning

confidence: 99%

“…This part dominates the scattering intensity at small scattering angles. For a spherical symmetric particle, this term is equal to the square of the scattering amplitude B ( q ), which could be described as shown below:

B ((), q) = 4 italicπb \int_{0}^{R} ([], ρ^{e} ((), r) - ρ_{m}^{e}) r^{2} \frac{sin italicqr}{qr} italicdr

where b is the Thomson scattering length and equal to 0.282 × 10 −14 m. R is the radius of the spherical particle, and (

ρ^{e} ((), r) - ρ_{m}^{e}

), that is, Δρ e ( r ), denotes the difference between the radial electron density of the particle ρ e ( r ) and the electron density of solvent

ρ_{m}^{e}

. Hence, it is obvious that the higher the contrast of electron density between particle and solvent is, the stronger the scattering signal will be.…”

Section: Methodsmentioning

confidence: 99%

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Controllable immobilization of proteins in quenched spherical polyelectrolyte brushes as observed by fluorescence spectroscopy and small angle X‐ray scattering

Zhao

et al. 2018

J Polym Sci B Polym Phys

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The immobilization of lysozymes (pI = 11) onto anionic spherical polyelectrolyte brushes (SPB) which consist of a solid polystyrene core and a densely grafted poly(styrene sulfonate) (PSS) shell was systematically studied by fluorescence spectroscopy and small angle X‐ray scattering. Results show that the capture of lysozyme by PSS brush is a dynamic process, which involves a quick agglomeration stage and a slow rearrangement one. And lysozyme inclines to immobilize in the inner layer of the brush, and saturation of lysozyme adsorption onto the SPB is gradually reached as the protein concentration increases, proceeding from the inside to the outside of the brush layers. As increasing the pH and ionic strength, the lysozyme previously adsorbed will be partially released and migrate from the inner to the outer layer of SPB. Last competitive adsorption tests between lysozyme and BSA or β‐glucosidase were performed, indicating that besides electrostatic interaction counterion release force also plays an important role in protein adsorption. SPB was proved to be ideal candidate for controllable immobilization of protein, which can be extended into various applications, such as drug delivery and protein separation. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 1577–1588

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q = ((), \frac{4 π}{λ}) sin ((), \frac{θ}{2})

…”

Section: Methodsmentioning

confidence: 99%

B ((), q) = 4 italicπb \int_{0}^{R} ([], ρ^{e} ((), r) - ρ_{m}^{e}) r^{2} \frac{sin italicqr}{qr} italicdr

where b is the Thomson scattering length and equal to 0.282 × 10 −14 m. R is the radius of the spherical particle, and (

ρ^{e} ((), r) - ρ_{m}^{e}

), that is, Δρ e ( r ), denotes the difference between the radial electron density of the particle ρ e ( r ) and the electron density of solvent

ρ_{m}^{e}

. Hence, it is obvious that the higher the contrast of electron density between particle and solvent is, the stronger the scattering signal will be.…”

Section: Methodsmentioning

confidence: 99%

Controllable immobilization of proteins in quenched spherical polyelectrolyte brushes as observed by fluorescence spectroscopy and small angle X‐ray scattering

Zhao

et al. 2018

J Polym Sci B Polym Phys

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“…Moreover, small-angle X-ray scattering (SAXS) of hollow capsules could give a detailed illustration of the inner structure and their size distribution in in situ measurements. SAXS investigations of PAH and poly-ʟaspartic acid multilayers deposited on poly(acrylic acid) (PAA) brush modified PS templates indicated that some PAH chains penetrated into the PAA brush [37]. Notably, SAXS proved to be a powerful tool to gain more information about the inner structure of such systems.…”

Section: Core Templatesmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

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“…More detailed tting process can be found in our previous publications. [41][42][43] Results and discussion…”

Section: Characterizationmentioning

confidence: 99%

Preparation and characterization of Ag–Pd bimetallic nano-catalysts in thermosensitive microgel nano-reactor

Zhang

et al. 2018

RSC Adv.

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Modification of Spherical Polyelectrolyte Brushes by Layer-by-Layer Self-Assembly as Observed by Small Angle X-ray Scattering

Cited by 16 publications

References 54 publications

Controllable immobilization of proteins in quenched spherical polyelectrolyte brushes as observed by fluorescence spectroscopy and small angle X‐ray scattering

Controllable immobilization of proteins in quenched spherical polyelectrolyte brushes as observed by fluorescence spectroscopy and small angle X‐ray scattering

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Preparation and characterization of Ag–Pd bimetallic nano-catalysts in thermosensitive microgel nano-reactor

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