Modification of respiratory function parameters in patients with severe Parkinson's disease

Pandis, Maria Francesca De; Starace, Antonio; Stefanelli, Francesco; Marruzzo, P; Meoli, Ilernando; Simone, G. De; Prati, Raquel; Stocchi, Fabrizio

doi:10.1007/s100720200074

Cited by 62 publications

(55 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16 The effect of levodopa on restrictive respiratory disease is controversial. some authors have shown an improvement in respiratory function after levodopa 13,14,16 whereas others did not. 17 These discrepancies may be due to differences in the patient's age, disease duration and severity and techniques used to assess respiratory function as well as the parameters measured.…”

Section: Restrictive Respiratory Dysfunctionmentioning

confidence: 95%

“…since sabate et al in 1996, 6 higher incidences of restrictive respiratory disease have been observed in Pd patients [13][14][15] and a link between this and the motor manifestations of Pd has been described. a restrictive pattern has been shown to correlate with falls and freezing but not with tremor, rigidity or bradykinesia.…”

Section: Restrictive Respiratory Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory Dysfunction in Parkinson'S Disease

Torsney

Forsyth

2017

Journal of the Royal College of Physicians of Edinburgh

View full text Add to dashboard Cite

Respiratory dysfunction has been associated with Parkinson's disease since it was first described in 1817. The respiratory symptoms observed in Parkinson's disease patients vary greatly. Most patients remain asymptomatic, whereas others present with acute shortness of breath and even stridor.In August 2016, an electronic literature search was conducted using PubMed and Google Scholar. Results were screened and studies reporting on respiratory dysfunction associated with Parkinson's disease were included.Respiratory dysfunction is due to a combination of factors including restrictive changes, upper airway obstruction, abnormal ventilatory drive and response to medications.Much debate surrounds the mechanism underlying respiratory dysfunction in Parkinson's disease, its prevalence and the effect of levodopa on respiration. It is clear from this review that larger studies, comparing patients of similar disease duration and severity using the same pulmonary function parameters, are required to provide a better understanding of the pathophysiology underlying respiratory dysfunction in Parkinson's disease.

show abstract

Section: Restrictive Respiratory Dysfunctionmentioning

confidence: 95%

Section: Restrictive Respiratory Dysfunctionmentioning

confidence: 99%

Respiratory Dysfunction in Parkinson'S Disease

Torsney

Forsyth

2017

Journal of the Royal College of Physicians of Edinburgh

View full text Add to dashboard Cite

show abstract

“…A avaliação da função pulmonar por este método constitui-se num importante indicador da condição respiratória de pacientes com DP. (17) As medidas de Capacidade Vital (CV) e a Capacidade Vital Forçada (CVF), encontram-se abaixo dos valores teóricos preconizados em pacientes parkinsonianos, (8,17,18) e podem ser decorrentes da rigidez da musculatura da caixa torácica e da bradicinesia. (8) Observa-se que ao comparar a função pulmonar de indivíduos com e sem a doença de Parkinson, pessoas com a doença apresentam redução da CV e CVF.…”

Section: Discussionunclassified

“…Embora o uso da Levodopa seja o tratamento medicamentoso mais eficaz disponível para a doença de Parkinson, existem resultados divergentes. (18) Estudos evidenciaram a melhora sobre a função pulmonar após a administração da Levodopa, (17,23) com aumento nos valores dos parâmetros avaliados, a exemplo da CVF e do PFE (23) na fase on da medicação. Credita--se essa melhora à reversão parcial da deficiência motora, resultando em diminuição do tremor e rigidez muscular, melhora na coordenação dos mús-culos e facilitação do movimento.…”

Section: Discussionunclassified

Alterações Funcionais Respiratórias Na Doença De Parkinson

Costa

Santos

Oliveira

et al. 2016

RPF

View full text Add to dashboard Cite

ResumoIntrodução: Caracterizada como uma patologia crônica, neurodegenerativa e progressiva, a Doença de Parkinson (DP) está relacionada a disfunções monoaminérgicas múltiplas, incluindo déficits dos sistemas dopaminérgicos, colinérgicos, serotoninérgicos e noradrenérgicos. Sintomas motores clás-sicos como a rigidez, bradicinesia, tremor em repouso e instabilidade postural são presentes nesta condição. Derivada desta tétrade motora, as alterações posturais, a rigidez e a bradicinesia levam à redução da força muscular respiratória, modificam a biomecânica da caixa torácica causando déficits na expansão pulmonar, podendo ainda, repercutir nos volumes e capacidades pulmonares. Objetivo: Sistematizar o conhecimento acerca das alterações funcionais respiratórias presentes na doença de Parkinson. Metodologia: Trata-se de um estudo de Revisão de Literatura. As bases de dados pesquisadas foram Bireme, Scielo e PubMed, e foram incluídos artigos originais, publicados a partir do ano de 2000, que avaliaram a função pulmonar com medidas da manobra de capacidade vital forçada (espirometria), pico de fluxo de tosse, força muscular respiratória e a mobilidade torácica. Foram excluídos artigos que avaliaram a função pulmonar com outros desfechos e aqueles que não foram disponibilizados na íntegra. Resultados: Foram encontrados 45 artigos, e após a aplicação dos critérios de inclusão e exclusão, foram selecionados 16 estudos. Considerações Finais: Esta revisão de literatura sugere que pessoas com Parkinson apresentam redução da mobilidade torácica, do pico de fluxo de tosse, da força muscular respiratória e de volumes e capacidades pulmonares, implicando no comprometimento da funcionalidade destes indivíduos. Introduction: Parkinson's Disease (PD) is a chronic progressive neurodegenerative pathology related to a multiple monoaminergic dysfunctions, including dopaminergic, cholinergic, serotoninergic and noradrenergic systems deficits. Classic motor system deficits like stiffness, bradikynesia, postural instability and tremors are present in such conditions. The motor system deficits lead to a reduction in respiratory muscle function and the lung mechanics and respiratory function are then modified. Objective: To summarize the PD impact on respiratory function knowledge through a systematized literature review. Methods: This is a literature review study. Bibliographic search was conducted in Bireme, Scielo and PubMed databases. Original papers published from January first, 2000 to June first 2016 were selected. Papers with pulmonary function with measurement of forced vital capacity, cough peak flow, respiratory muscle strength and thoracic mobility were included. Papers with other outcomes and those whose authors had not acess to full text versions were excluded. Results: Forty-five papers were initially selected, being 29 excluded. At the end, sixteen papers entered in the study, and two of them evaluated thoracic mobility, 11 evaluated cogh peak flow and forced vital capacity, and four evaluated respiratory muscle strength. Fi...

show abstract

“…When present, the most common patterns have been characterized as restrictive pulmonary dysfunction, obstructive airflow disease, and upper airway obstruction [1,[7][8][9][21][22][23][24]. Abnormal ventilatory control has also been described, even though respiratory flows and volumes were normal in most of the patients [25].…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of pulmonary function in Parkinson's disease patients with motor fluctuations

Hampson

Kieburtz²,

LeWitt

et al. 2016

International Journal of Neuroscience

View full text Add to dashboard Cite

Background. Spirometry patterns suggesting restrictive and obstructive pulmonary dysfunction have been reported in Parkinson's disease (PD). However, the patterns' precise relation to PD pathophysiology remains unclear. Purpose/Aim. To assess ON-versus OFF-state pulmonary function, the quality of its spirometric evaluation, and the quality of longitudinal spirometric findings in a large sample of PD patients with motor fluctuations. Methods. During a placebo-controlled trial of an inhaled levodopa formulation, CVT-301, in PD patients with ≥2 h/d of OFF time, spirometry was performed by American Thoracic Society (ATS) guidelines at screening and throughout the 4-week treatment period. Results. Among 86 patients, mean motor impairment during an OFF state at screening was moderately severe. However, mean spirometry results at screening were within normal ranges, and in a mixed model for repeated measures (MMRM), the results at screening were not dependent on motor state (ON vs. OFF). In the placebo group (n = 43), 76% of ON-state and 81% of OFF-state examinations throughout the study met ATS quality metrics, and in an MMRM analysis, mean findings at these patients' arrivals for treatment-period visits showed no significant 4-week change. Across all 86 patients, flow-volume curves prior to any study-drug administration showed only a 3% incidence of "sawtooth" morphology. Conclusions. In PD patients with motor fluctuations, longitudinal spirometry of acceptable quality was generally obtained. Although mean findings were normal, about a quarter of spirograms did not meet ATS quality criteria. Spirogram morphology may be less indicative of various forms of respiratory dysfunction than has previously been reported in PD.

show abstract

Modification of respiratory function parameters in patients with severe Parkinson's disease

Cited by 62 publications

References 0 publications

Respiratory Dysfunction in Parkinson'S Disease

Respiratory Dysfunction in Parkinson'S Disease

Alterações Funcionais Respiratórias Na Doença De Parkinson

Prospective evaluation of pulmonary function in Parkinson's disease patients with motor fluctuations

Contact Info

Product

Resources

About