2021
DOI: 10.1016/j.actbio.2021.05.009
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Modification of polyetheretherketone implants: From enhancing bone integration to enabling multi-modal therapeutics

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Cited by 90 publications
(71 citation statements)
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“…Notably, the S. aureus -treated PEEK/GL13K-EDC sample showed negligible bacterial adhesion and superior biofilm resistance ( Figure 6 e) due to its high hydrophilicity and smooth surface. This highly hydrophilic surface could maintain the simultaneous functions of biofilm resistance and soft tissue attachment for implantable applications [ 7 , 19 ]. Thus, the developed coating was effective at inhibiting bacterial attachment.…”
Section: Resultsmentioning
confidence: 99%
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“…Notably, the S. aureus -treated PEEK/GL13K-EDC sample showed negligible bacterial adhesion and superior biofilm resistance ( Figure 6 e) due to its high hydrophilicity and smooth surface. This highly hydrophilic surface could maintain the simultaneous functions of biofilm resistance and soft tissue attachment for implantable applications [ 7 , 19 ]. Thus, the developed coating was effective at inhibiting bacterial attachment.…”
Section: Resultsmentioning
confidence: 99%
“…Among these, the thermoplastic polyetheretherketone (PEEK) is a state-of-the-art material due to its superior chemical resistance, thermal stability, mechanical strength similar to cortical bone, and radiolucent property [ 5 , 6 ]. PEEK has the potential to replace traditional ceramic and metal- or alloy-based implantable devices for dental, spinal, joint, and orthopedic applications [ 7 , 8 , 9 , 10 ]. However, the hydrophobicity of the pure PEEK increases the chance of biofilm formations and may not eliminate post-surgical bacterial infection [ 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Its advantages include favorable mechanical properties, such as high strength and stiffness, with an elastic modulus comparable to that of human bone. It is radiolucent and can be prefabricated as a patient-specific implant [48,49]. However, PEEK is a highly hydrophobic material and therefore does not osseointegrate because it lacks bioactive potential [50].…”
Section: Biomaterialsmentioning
confidence: 99%
“…Another example that has become increasingly popular recently, comprises the polymeric material polyetheretherketone, also known as PEEK, which is characterized by its high thermostability and potential for high-load. Since it is highly bone-friendly and more compatible with diagnostic imaging compared to metal materials it has an important role as new standard biomaterial for a wide range of applications [25]. Although quite promising, this material has to be improved concerning its limited bioinertness and lack of antibacterial properties.…”
Section: Figurementioning
confidence: 99%