Modification of polyetheretherketone implants: From enhancing bone integration to enabling multi-modal therapeutics

He, Miaomiao; Huang, Yong; Xu, Huan; Feng, Ganjun; Liu, Limin; Li, Yubao; Sun, Dan; Zhang, Li

doi:10.1016/j.actbio.2021.05.009

Cited by 90 publications

(71 citation statements)

References 159 publications

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“…Notably, the S. aureus -treated PEEK/GL13K-EDC sample showed negligible bacterial adhesion and superior biofilm resistance ( Figure 6 e) due to its high hydrophilicity and smooth surface. This highly hydrophilic surface could maintain the simultaneous functions of biofilm resistance and soft tissue attachment for implantable applications [ 7 , 19 ]. Thus, the developed coating was effective at inhibiting bacterial attachment.…”

Section: Resultsmentioning

confidence: 99%

“…Among these, the thermoplastic polyetheretherketone (PEEK) is a state-of-the-art material due to its superior chemical resistance, thermal stability, mechanical strength similar to cortical bone, and radiolucent property [ 5 , 6 ]. PEEK has the potential to replace traditional ceramic and metal- or alloy-based implantable devices for dental, spinal, joint, and orthopedic applications [ 7 , 8 , 9 , 10 ]. However, the hydrophobicity of the pure PEEK increases the chance of biofilm formations and may not eliminate post-surgical bacterial infection [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other AMPs than GL13K were coated on PEEK substrates [ 17 , 30 , 31 , 32 , 33 ]. The conventional peptide coating procedure for a PEEK surface involves roughing using sandpaper, plasma spraying, and alkaline and sulfonating or acid treatments to activate the PEEK surface [ 7 , 34 , 35 ]. However, the usage of sandpaper induces scratches and pinhole cracks on the PEEK surface, whereas a plasma spray may alter the polymeric chains.…”

Section: Introductionmentioning

confidence: 99%

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Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity

Kumar

Tuong

et al. 2021

IJMS

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In the present work, the antimicrobial peptide (AMP) of GL13K was successfully coated onto a polyetheretherketone (PEEK) substrate to investigate its antibacterial activities against Staphylococcus aureus (S. aureus) bacteria. To improve the coating efficiency, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) was mixed with a GL13K solution and coated on the PEEK surface for comparison. Both energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) data confirmed 30% greater peptide coating on PEEK/GL13K-EDC than PEEK without EDC treatment. The GL13K graft levels are depicted in the micrograms per square centimeter range. The PEEK/GL13K-EDC sample showed a smoother and lower roughness (Rq of 0.530 µm) than the PEEK/GL13K (0.634 µm) and PEEK (0.697 µm) samples. The surface of the PEEK/GL13K-EDC was more hydrophilic (with a water contact angle of 24°) than the PEEK/GL13K (40°) and pure PEEK (89°) samples. The pure PEEK disc did not exhibit any inhibition zone against S. aureus. After peptide coating, the samples demonstrated significant zones of inhibition: 28 mm and 25 mm for the PEEK/GL13K-EDC and PEEK/GL13K samples, respectively. The bacteria-challenged PEEK sample showed numerous bacteria clusters, whereas PEEK/GL13K contained a little bacteria and PEEK/GL13K-EDC had no bacterial attachment. The results confirm that the GL13K peptide coating was able to induce antibacterial and biofilm-inhibitory effects. To the best of our knowledge, this is the first report of successful GL13K peptide grafting on a PEEK substrate via EDC coupling. The present work illustrates a facile and promising coating technique for a polymeric surface to provide bactericidal activity and biofilm resistance to medical implantable devices.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity

Kumar

Tuong

et al. 2021

IJMS

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“…Its advantages include favorable mechanical properties, such as high strength and stiffness, with an elastic modulus comparable to that of human bone. It is radiolucent and can be prefabricated as a patient-specific implant [48,49]. However, PEEK is a highly hydrophobic material and therefore does not osseointegrate because it lacks bioactive potential [50].…”

Section: Biomaterialsmentioning

confidence: 99%

A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration

et al. 2022

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Current cranial repair techniques combine the use of autologous bone grafts and biomaterials. In addition to their association with harvesting morbidity, autografts are often limited by insufficient quantity of bone stock. Biomaterials lead to better outcomes, but their effectiveness is often compromised by the unpredictable lack of integration and structural failure. Bone tissue engineering offers the promising alternative of generating constructs composed of instructive biomaterials including cells or cell-secreted products, which could enhance the outcome of reconstructive treatments. This review focuses on cell-based approaches with potential to regenerate calvarial bone defects, including human studies and preclinical research. Further, we discuss strategies to deliver extracellular matrix, conditioned media and extracellular vesicles derived from cell cultures. Recent advances in 3D printing and bioprinting techniques that appear to be promising for cranial reconstruction are also discussed. Finally, we review cell-based gene therapy approaches, covering both unregulated and regulated gene switches that can create spatiotemporal patterns of transgenic therapeutic molecules. In summary, this review provides an overview of the current developments in cell-based strategies with potential to enhance the surgical armamentarium for regenerating cranial vault defects.

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“…Another example that has become increasingly popular recently, comprises the polymeric material polyetheretherketone, also known as PEEK, which is characterized by its high thermostability and potential for high-load. Since it is highly bone-friendly and more compatible with diagnostic imaging compared to metal materials it has an important role as new standard biomaterial for a wide range of applications [25]. Although quite promising, this material has to be improved concerning its limited bioinertness and lack of antibacterial properties.…”

Section: Figurementioning

confidence: 99%

Application of Antimicrobial Peptides on Biomedical Implants: Three Ways to Pursue Peptide Coatings

Drexelius

Neundorf

2021

IJMS

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Biofilm formation and inflammations are number one reasons of implant failure and cause a severe number of postoperative complications every year. To functionalize implant surfaces with antibiotic agents provides perspectives to minimize and/or prevent bacterial adhesion and proliferation. In recent years, antimicrobial peptides (AMP) have been evolved as promising alternatives to commonly used antibiotics, and have been seen as potent candidates for antimicrobial surface coatings. This review aims to summarize recent developments in this field and to highlight examples of the most common techniques used for preparing such AMP-based medical devices. We will report on three different ways to pursue peptide coatings, using either binding sequences (primary approach), linker layers (secondary approach), or loading in matrixes which offer a defined release (tertiary approach). All of them will be discussed in the light of current research in this area.

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Modification of polyetheretherketone implants: From enhancing bone integration to enabling multi-modal therapeutics

Cited by 90 publications

References 159 publications

Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity

Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity

A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration

Application of Antimicrobial Peptides on Biomedical Implants: Three Ways to Pursue Peptide Coatings

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