Modification of polycystic kidney disease and fatty acid status by soy protein diet

Ogborn, Malcolm R.; Nitschmann, Evan; Weiler, Hope A.; Bankovic-Calic, Neda

doi:10.1046/j.1523-1755.2000.00835.x

Cited by 57 publications

(69 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of an effect of genistein on serum creatinine, kidney size and kidney water content (reflecting cyst growth) was also observed in another model of renal cyst disease, the pcy mouse, in which dietary soya protein has been shown to slow disease progression (Tomobe et al 1998). In contrast, the soya protein given in the weaning period of the current study did affect these parameters, as previously shown (Ogborn et al , 2000Aukema & Housini, 2001;Fair et al 2004). Therefore, the effects of soya protein on disease progression are likely due to several components in the diet and the difference in effects of dietary soya protein in the maternal compared with the weaning periods suggests different mechanisms of action of soya protein at different life stages.…”

Section: Discussionsupporting

confidence: 84%

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

et al. 2007

Self Cite

View full text Add to dashboard Cite

Dietary soya protein substitution for casein initiated at weaning slows disease progression in animal models of chronic renal disease. As there is increasing evidence that fetal programming can have a significant impact on kidney physiology and function in offspring, the objective of the current study was to determine whether exposure to soya protein in the diet earlier than weaning would have further benefits. Han:SPRD-cy (cy/þ ) breeder rats were fed a casein-based or soya protein-based diet 2 weeks prior to mating, throughout pregnancy and during lactation. Following this maternal period, 3-week-old pups were given either the same or the alternate diet for a 7-week weaning period. Dietary soya protein compared with casein in the maternal or weaning period both independently resulted in less renal inflammation (macrophage infiltration lower by 24 % (P¼ 0·0003) and 32 % (P, 0·0001), respectively). When soya protein was given in both feeding periods, the effect was additive. Soya protein substitution for casein resulted in less oxidative damage as indicated by 28 % lower oxidized-LDL staining (P¼ 0·013) when present in the maternal period, or in the weaning period (by 56 %, P,0·0001). Renal cell proliferation was reduced by 29-33 % (P,0·05) in rats given soya protein whether the exposure was during the maternal or weaning period. Soya protein compared with casein in the maternal period also resulted in 33 % (P¼ 0·0013) less proteinuria, indicating superior renal function. Dietary soya protein during pregnancy and lactation represents a potential preventative approach in treating for those with congenital kidney diseases.

show abstract

Section: Discussionsupporting

confidence: 84%

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…Left kidneys, fixed in 10% buffered formalin, were embedded in paraffin, sectioned at 5 µm and processed using our previously described methods for histological and immunohistochemical analyses [4, 5, 8, 9]. Sections for cyst area measurement were stained with hematoxylin and eosin and those for quantitative analysis of fibrosis with Sirius red (in adaptation of Masson’s trichrome stain) which permits image analysis measurement using a standard incandescent microscope light source.…”

Section: Methodsmentioning

confidence: 99%

“…Dietary soy protein has been associated with renoprotective effects in several models of early CKD, including rats with chronic nephriticsyndrome [2], rats with early diabetic nephropathy [3] and rat and mouse modelsof polycystic kidney disease (PKD) [4,5,6,7]. Flax oil-based diets also are beneficial in ameliorating early kidney disease in rats and mice with PKD [8, 9].…”

Section: Introductionmentioning

confidence: 99%

“…Since there are no studies that have examined the effects of dietary intervention of dietary soy protein and flax oil in adult Han:SPRD- cy rats with established renal disease, the aim of this study was to determine whether dietary soy protein or flax oil supplementation could alter further progression of renal injury in Han:SPRD- cy rats with advanced PKD. In addition to assessing disease progression using biochemical, morphological and immunohistochemical parameters, we also examined renal fatty acid concentrations to provide insight into whether soy protein or flax oil diets alter fatty acid profiles in advanced renal injury, similar to the alterations previously reported in early renal disease [4, 5, 8, 9]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Sankaran¹,

Bankovic-Calic²,

Cahill³

et al. 2007

Nephron Exp Nephrol

Self Cite

View full text Add to dashboard Cite

Background/Aims: Dietary soy protein and flax oil retard kidney disease progression when initiated in the early stages of disease in several experimental models, including the Han:SPRD-cy rat. However, individuals with kidney disease often do not become aware of their condition until injury to the kidney is extensive. The objective of this study was to determine whether initiating these interventions in established disease would alter further progression of renal injury. Methods: Two-month-old adult male Han:SPRD-cy rats were given either a flax oil diet (7% flax oil), a soy protein diet (20% soy protein) or a control diet (7% corn oil, 20% casein) for 4 months. Renal disease progression was assessed by examining morphological, immunohistochemical and biochemical parameters. Results: Compared to controls, there was 21–24% less staining of proliferating cells, 21–24% less oxidative damage and 13–15% less renal inflammation in kidneys from rats given dietary soy protein and flax oil. Renal cystic growth and fibrosis and serum creatinine levels were not altered by these dietary treatments. Conclusions: Late intervention with dietary soy protein and flax oil reduces some disease-associated pathologies in established renal disease in Han:SPRD-cy rats. The potential benefits of the antioxidant and anti-inflammatory effects on ultimate renal disease outcome in the long term remains to be determined.

show abstract

“…Запрошені статті / Guest Articles экспрессия трансформирующего фактора роста бета [49,50]. Не только содержание белка, но и белковый состав диеты могут влиять на развитие поликистозно-го заболевания почек.…”

Section: диета при адпкпunclassified

Патогенез І Потенційна Терапія Автосомно-Домінантного Полікістозу Нирок

Melnyk¹

2021

KIDNEYS

View full text Add to dashboard Cite

Кистозная болезнь почек -это группа наслед-ственных или приобретенных заболеваний, которые характеризуются присутствием и ростом в почках единичных или множественных кист, представля-ющих собой закрытую полость, окаймленную эпи-телием и заполненную жидким или желеобразным экссудатом. По своей структуре киста представляет собой расширенный сегмент нефрона или собира-тельной трубки, а ее размер определяется количе-ством содержимого и варьирует от мелкого (менее 2 мм в диаметре) до гигантского. Кистозная жид-кость сообщается с кровеносными сосудами, содер-жимым канальцев и почечной лоханки.Почечные кисты классифицируют в зависимо-сти от происхождения -негенетического и генети-ческого (табл. 1).Одной из форм кистозной болезни почек явля-ется поликистозная болезнь почек (ПБП). ПБП -это генетическое заболевание, которое приводит к образованию и прогрессированию множественных кист в паренхиме почек и в конечном итоге может привести к терминальной стадии болезни почек (ТПН). Это четвертая ведущая причина хрониче-ского заболевания почек, приводящая к ТПН.УДК 616.61.053:658.265 DOI: 10.22141/2307616.61.053:658.265 DOI: 10.22141/ -1257616.61.053:658.265 DOI: 10.22141/ .6.4.2017 Мельник А.А. Ключевые слова: аутосомно-доминантное поликистозное заболевание почек; полицистин-1; по-лицистин-2; реснички; лечениеАутосомно-доминантная поликистозная бо-лезнь почек (АДПБП) является наиболее рас-пространенной формой ПБП с частотой 1 : 400 -1 : 1000 случаев, которой страдают 12,5 млн человек во всем мире всех этнических групп и которая со-ставляют 4-10 % больных ТПН, получающих ле-чение заместительной почечной терапией [1]. У 85-90 % пациентов АДПБП является результатом мутации гена PKD-1, в то время как 10-15 % слу-чаев обусловлены мутацией гена PKD-2 [2]. Ген PKD-1 (polycystic kidney disease 1) кодирует инте-гральный мембранный белок полицистин-1 (РС-1), а ген PKD-2 (polycystic kidney disease 2) -белок по-лицистин-2 (РС-2) [3]. Полицистин-1. Структура и функцияБелок РС-1 имеет молекулярную массу (м.м.) 462 кДа, состоит из 4302 аминокислот с 11 транс-мембранными доменами. В своей структуре содер-жит большой внеклеточный N-конец и короткий С-конец [4]. РС-1 экспрессируется эпителиальны-ми, развивающимися и зрелыми клетками почеч-ных канальцев, а также различными тканями, вклю-чая сердце, печень, кости и эндокринные железы

show abstract

Modification of polycystic kidney disease and fatty acid status by soy protein diet

Cited by 57 publications

References 39 publications

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Патогенез І Потенційна Терапія Автосомно-Домінантного Полікістозу Нирок

Contact Info

Product

Resources

About