Modification of LC Phenotype and Suppression of Contact Hypersensitivity Response by Stress

Hosoi, Junichi; Tsuchiya, Toru; Denda, Mitsuhiro; Ashida, Yutaka; Takashima, Akira; Granstein, Richard D.; Koyama, Junichi

doi:10.1177/120347549800300205

Cited by 34 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perhaps reduced cortisolic responses coupled with stimulation of cutaneous T-cell trafficking 40 play a role, as has been demonstrated in experiments in mice whereby an allergic contact dermatitis response is enhanced in stressed animals. 41 These findings provide further evidence of the existence of a brain-skin axis. Focus on this fascinating area is needed to identify potential mechanisms and to encompass a holistic approach to the treatment of chronic inflammatory skin disease.…”

Section: Commentsupporting

confidence: 55%

Psychological Distress Impairs Clearance of Psoriasis in Patients Treated With Photochemotherapy

Fortune¹,

Richards²,

Kirby³

et al. 2003

Arch Dermatol

208

161

View full text Add to dashboard Cite

Section: Commentsupporting

confidence: 55%

Psychological Distress Impairs Clearance of Psoriasis in Patients Treated With Photochemotherapy

Fortune¹,

Richards²,

Kirby³

et al. 2003

Arch Dermatol

208

161

View full text Add to dashboard Cite

“…Indeed, it has been shown that immobilization stress in mice inhibits elicitation of DTH when the adrenal axis is intact (53). Likewise, CHS reactions in mice have been reported to be suppressed by psychological and social stress induced by immobilization and overcrowding, respectively (54,55). Interestingly, in regard to CHS, a recent study by Flint et al (56) demonstrated that acute restraint before sensitization diminished CHS, whereas restraint administered before challenge enhanced CHS.…”

Section: Figure 5 Intradermal Injection Of Epi Inhibits Chs Inductionmentioning

confidence: 98%

Catecholamines Inhibit the Antigen-Presenting Capability of Epidermal Langerhans Cells

Seiffert¹,

Hosoi²,

Torii³

et al. 2002

The Journal of Immunology

Self Cite

116

View full text Add to dashboard Cite

The sympathetic nervous system modulates immune function at a number of levels. Within the epidermis, APCs (Langerhans cells (LC)) are frequently anatomically associated with peripheral nerves. Furthermore, some neuropeptides have been shown to regulate LC Ag-presenting function. We explored the expression of adrenergic receptors (AR) in murine LC and assessed their functional role on Ag presentation and modulation of cutaneous immune responses. Both purified LC and the LC-like cell lines XS52-4D and XS106 expressed mRNA for the ARs α1A and β2. XS106 cells and purified LC also expressed β1-AR mRNA. Treatment of murine epidermal cell preparations with epinephrine (EPI) or norepinephrine inhibited Ag presentation in vitro. Furthermore, pretreatment of epidermal cells with EPI or norepinephrine in vitro suppressed the ability of these cells to present Ag for elicitation of delayed-type hypersensitivity in previously immunized mice. This effect was blocked by use of the β2-adrenergic antagonist ICI 118,551 but not by the α-antagonist phentolamine. Local intradermal injection of EPI inhibited the induction of contact hypersensitivity to epicutaneously administered haptens. Surprisingly, injection of EPI at a distant site also suppressed induction of contact hypersensitivity. Thus, catecholamines may have both local and systemic effects. We conclude that specific ARs are expressed on LC and that signaling through these receptors can decrease epidermal immune reactions.

show abstract

“…For example, stress has been shown to impair lymphocyte function [77]. Stress has also been shown to decrease the density of Langerhans cells in the epidermis in both mice and humans [78, 79]. Langerhans cells are epidermal members of the dendritic cell family of antigen-presenting cells.…”

Section: Impact Of Psychological Stress On Innate and Adaptive Immmentioning

confidence: 99%

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Hall

Cruser

Podawiltz

et al. 2012

Dermatology Research and Practice

122

106

View full text Add to dashboard Cite

Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis.

show abstract

Modification of LC Phenotype and Suppression of Contact Hypersensitivity Response by Stress

Abstract: Stress affected the cutaneous immune system. There were indications that adrenergic hormones played a role in the regulation of the system.

Cited by 34 publications

References 21 publications

Psychological Distress Impairs Clearance of Psoriasis in Patients Treated With Photochemotherapy

Psychological Distress Impairs Clearance of Psoriasis in Patients Treated With Photochemotherapy

Catecholamines Inhibit the Antigen-Presenting Capability of Epidermal Langerhans Cells

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Contact Info

Product

Resources

About