Modification of glycidyl methacrylate based block copolymers and their aqueous solution behaviours

Koçak, Gökhan; Solmaz, Gökhan; Tuncer, Cansel; Bütün, Vural

doi:10.1016/j.eurpolymj.2018.11.046

Cited by 18 publications

(16 citation statements)

References 67 publications

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“…Tertiary amine‐based polymers, for example, PDMA, are quaternizable by alkyl and aryl halides, similar to the piperazine‐containing polymers . In this study, crosslinked films were obtained using a BIEE crosslinker with bifunctional alkyl iodide.…”

Section: Resultsmentioning

confidence: 99%

“…Glycidyl methacrylate (GMA) monomer, often used to produce functional polymers, is very reactive, cheap, and suitable for various polymerization reactions . Various secondary amines cause the ring‐opening reaction to the epoxy groups of GMA, which leads to the production of tertiary amine and hydroxy‐based bifunctional polymers . We have already investigated the modification of poly(glycidyl methacrylate) (PGMA)‐containing polymers with various secondary amines (1‐methylpiperazine, diethylamine, and morpholine) and their behaviors in aqueous solutions .…”

Section: Introductionmentioning

confidence: 99%

“…Various secondary amines cause the ring‐opening reaction to the epoxy groups of GMA, which leads to the production of tertiary amine and hydroxy‐based bifunctional polymers . We have already investigated the modification of poly(glycidyl methacrylate) (PGMA)‐containing polymers with various secondary amines (1‐methylpiperazine, diethylamine, and morpholine) and their behaviors in aqueous solutions . These studies also produced the quaternary products of (co)polymers containing 2‐hydroxy‐3‐methyl piperazinepropyl methacrylate (HMPPMA units using 1‐methyl piperazine with different alkyl and aryl halides .…”

Section: Introductionmentioning

confidence: 99%

“…We have already investigated the modification of poly(glycidyl methacrylate) (PGMA)‐containing polymers with various secondary amines (1‐methylpiperazine, diethylamine, and morpholine) and their behaviors in aqueous solutions . These studies also produced the quaternary products of (co)polymers containing 2‐hydroxy‐3‐methyl piperazinepropyl methacrylate (HMPPMA units using 1‐methyl piperazine with different alkyl and aryl halides . In this study, the crosslinked films were produced by quaternization reaction using bifunctional 1,2‐bis(2‐iodoethoxy)ethane (BIEE) that has been used in crosslinking of poly[(2 ‐ dimethylamino)ethyl methacrylate] (DMA) and poly(4‐vinyl pyridine) containing polymers .…”

Section: Introductionmentioning

confidence: 99%

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Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

Koçak

2019

J of Applied Polymer Sci

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Metal‐nanoparticle (M‐NP)‐modified glycidyl methacrylate (GMA)‐based hydrogel film composites were synthesized and assessed for their catalytic activities by reducing para‐nitrophenol (p‐NP) to para‐aminophenol (p‐AP) with sodium borohydride. Poly(ethylene glycol)methyl ether‐block‐poly(glycidyl methacrylate)‐block‐poly(methyl methacrylate) (MPEG‐b‐PGMA‐b‐PMMA) triblock copolymer was synthesized via atom transfer‐radical polymerization. The epoxy ring of the PGMA blocks was opened by the addition of 1‐methylpiperazine. The resulting bifunctional polymer containing 2‐hydroxy‐3‐methyl piperazinepropyl methacrylate units was used to synthesize novel crosslinked hydrogel films by quaternization of the tertiary amine (methylpiperazine) with 1,2‐bis(2‐iodoethoxy)ethane. The synthesized hydrogel film swelled in aqueous solution when the pH was changed from basic to acidic. The prepared MPEG‐b‐PHMPPMA‐b‐PMMA hydrogel film was used as an immobilizing matrix to form monometallic silver (Ag) and gold (Au) and bimetallic alloy gold:silver (Au:Ag) nanoparticles. The M‐NP/hydrogel film composites were characterized by transmission electron microscopy, scanning electron microscopy, thermogravimetric analysis, and ultraviolet–visible spectrophotometry. The synthesized M‐NP/hydrogel film composites showed good catalytic activity to reduce p‐NP to p‐AP. The composites were also found to be reusable as their activity only slightly dropped after 10 consecutive uses. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48360.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

Koçak

2019

J of Applied Polymer Sci

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“…As a result, drug delivery vehicles that may be triggered by pH variations are effective and highly desired for treating tumors [107]. Dendrimers are formed using various functional groups, whose pH-dependent release is achieved by disturbing the amphiphilicity of the environment [108]. The disruption of the amphiphilicity of the system can be achieved through the cleavage of primary covalent bonds or interfering with the charges in the dendrimer [109].…”

Section: Recent Trends Of Stimuli-responsive Dendrimers In Controlmentioning

confidence: 99%

Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

Nguyen

Cao

et al. 2019

Pharmaceutics

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Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at the target site, responding to stimuli that originated from internal changes within the body, as well as stimuli manipulated by external sources has recently received significant attention. Owning to the spherical shape and porous structure, dendrimer is utilized as a material for drug delivery. Moreover, the surface region of dendrimer has various moieties facilitating the surface functionalization to develop the desired material. Therefore, multi-stimuli-responsive dendrimers or ‘smart’ dendrimers that respond to more than two stimuli will be an inspired attempt to achieve the site-specific release and reduce as much as possible the side effects of the drug. The aim of this review was to delve much deeper into the recent progress of multi-stimuli-responsive dendrimers in the delivery of anticancer drugs in addition to the major potential challenges.

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Synthesis of quaternary piperazine methacrylate homopolymers and their antibiofilm and anti‐quorum sensing effects on pathogenic bacteria

Koçak

Tamfu

Bütün

et al. 2021

J of Applied Polymer Sci

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In this work, poly(glycidyl methacrylate) (PGMA, G) homopolymers with different molecular weights (5600-21,000 gmol −1) were synthesized by atom transfer radical polymerization (ATRP) method. Epoxy groups of PGMA homopolymers were converted to hydroxyl and 1-methyl piperazin residues by reacting with 1-methyl piperazine via ring-opening reaction. The obtained poly(2-hydroxy-3-methyl piperazinepropyl methacrylate) (PHMPPMA, G-P) homopolymers (from 9450 to 35,900 gmol −1) were reacted with alkyl halides of different carbon chain lengths (methyl-, ethyl-, propyl-, butyl-, pentyl-iodides, hexyl bromide) and benzyl chloride (arylhalide) to form quaternary PHMPPMA homopolymers (G-QP). MIC values varied from 0.125 mg/ml to

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Modification of glycidyl methacrylate based block copolymers and their aqueous solution behaviours

Cited by 18 publications

References 67 publications

Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

Synthesis of quaternary piperazine methacrylate homopolymers and their antibiofilm and anti‐quorum sensing effects on pathogenic bacteria

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