Modification of fracture repair with selected pulsing electromagnetic fields.

Bassett, C. Andrew L.; Valdés, Michel; Hernandez, Eder

doi:10.2106/00004623-198264060-00012

Cited by 110 publications

(36 citation statements)

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“…The use of specific electromagnetic fields for the treatment of nonunions is well known [2,14,20]. The union rates of ununited fractures treated with pulsed electromagnetic fields (PEMF) are greater than 80% [1,11,20].…”

Section: Introductionmentioning

confidence: 99%

The effect of an intramedullary implant with a static magnetic field on the healing of the osteotomised rabbit femur

Aydın

Bezer

2010

International Orthopaedics (SICOT)

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Static magnetic fields are a type of electromagnetic fields used in clinical practice. To ascertain what effect a static magnetic intramedullary device implanted in the rabbit femur had on fracture healing, 20 male New Zealand white rabbits with magnetic/nonmagnetic intramedullary implants were examined histologically, radiologically and for bone mineral density. Three groups were constituted according to the poles of the magnets. During surgery the intramedullary device was driven into the medulla. A femoral osteotomy was created with a mini Gigli wire at the centre point of the rod. Radiographs were obtained at the second and fourth weeks. Histological examination and bone mineral density were evaluated at the fourth week. The results of this study verified that an intramedullary implant with a static magnetic field improves bone healing in the first two weeks radiologically and that the configuration difference in magnetic poles has an effect on bone quality. Static magnetic fields have minor effects on bone mineral density values.

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Section: Introductionmentioning

confidence: 99%

The effect of an intramedullary implant with a static magnetic field on the healing of the osteotomised rabbit femur

Aydın

Bezer

2010

International Orthopaedics (SICOT)

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“…Small animal models, such as rat and rabbit models, have been used to test the various PEMF signals for bone healing [5,18,28]. Large animal models are necessary to develop clinical application protocols and to validate the benefit of PEMF treatment on functional outcomes.…”

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confidence: 99%

“…Large animal models are necessary to develop clinical application protocols and to validate the benefit of PEMF treatment on functional outcomes. Despite the well-established positive effect of PEMF on osteogenic activities [5,18,25,27,28], results obtained using large animal models, such as horses, canines, and sheep, are still controversial. Positive effects of PEMF on new-bone formation have been shown in a N. h o u r et ul.…”

mentioning

confidence: 99%

Effect of pulsed electromagnetic fields (PEMF) on late‐phase osteotomy gap healing in a canine tibial model

Inoue

Ohnishi

Chen

et al. 2002

Journal Orthopaedic Research

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The effects of a pulsed electromagnetic field (PEMF) on late bone healing phases using an osteotomy gap model in the canine mid-tibia were investigated. A transverse mid-diaphyseal tibial osteotomy with a 2-mm gap was performed unilaterally in 12 adult mixed-breed dogs and stabilized with external fixation. Animals in the variable group ( n = 6) were treated with PEMF for 1 h daily starting 4 weeks after surgery for a total of 8 weeks, whereas no stimulation signal was generated in the control group (n = 6). Functional load-bearing and radiographic assessments were conducted time-sequentially until euthanasia 12 weeks after surgery. Torsional tests and an analysis of undecakified histology were performed on the retrieved mid-tibia1 diaphysis containing the osteotomy site. In the PEMF group, load-bearing of the operated limb recovered earlier when compared to the control group (p < 0.05). Load-bearing in the PEMF group at 8 weeks was greater than in the control group 0, < 0.02). The periosteal callus area increased following surgery at 6 weeks (p < 0.05) and thereafter (p < 0.01) in the PEMF group, while a significant increase was observed at 8 and 10 weeks after surgery (p < 0.05) in the control group. Both the normalized maximum torque and torsional stiffness of the PEMF group were significantly greater than those of the control group (p < 0.04 and p < 0.007, respectively). Histomorphometric analyses revealed greater new-bone formation (p < 0.05) in the osteotomy gap tissue and increased mineral apposition rate (p < 0.04) and decreased porosity in the cortex adjacent to the osteotomy line (p < 0.02) in the PEMF group. PEMF stimulation of 1 h per day for 8 weeks provided faster recovery of load-bearing, a significant increase in new bone formation, and a higher mechanical strength of the healing mid-tibia1 osteotomy. This study revealed enhancing effects of PEMF o n callus formation and maturation in the late-phase of bone healing.

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“…1974'te, 41 av köpeğinin fi bula osteotomisi bölgesine uygulanan DFDEMA (maksimum 20 mV/cm'lik bir doku voltajı indükle-yerek 0,15 milisaniyelik süredeki akım darbeleri 65 Hz )'nın histolojik ve radyolojik olarak iyileşmeyi artırdığını rapor ettiler. Bassett ve arkadaşları 36 diğer bir çalışmalarında; ratların radiusuna yapılan osteotominin mekanik ve histolojik iyileşmeye etkileri için postoperatif 14 gün DEMA uygulamışlar, kırık iyileşmesinin erken evresinde, daha geniş kalsifi kasyon ve fi bröz kallusun oluştuğunu tespit etmişlerdir. Ottani ve arkadaşları 37 tibial osteotomi uyguladıkları sıçanları DFDEMA'na (bir çift yarım dalga puls ve 50 Hz,70G) maruz bırakıp 2, 3, 5 ve 8. haftalarda kemiğin iyileşme oranını ışık ve elektron mikroskoplarıyla değerlendirmişler ve EMA uygulanan sıçanlarda EMA'ların hücresel düzeydeki diğer rapor edilen etki mekanizmaları: Bağ dokusunda ekstraselüler matriks proteinlerini kodlayan gen ekspresyonunu düzen-leyerek kıkırdak ve kemik doku oluşumunu 16 ve osteoblastları uyarır 45 .…”

Section: Ema'ların Kırık Iyileșmesini Olumlu Etkilediğini Bildiren çAunclassified

The effects of low and high frequency electromagnetic fields on fracture healing

Aslan¹

2012

Kafkas J Med Sci

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Kırık iyileșmesiVücuttaki onarım olayları içerisinde, skar dokusu ile sonlanmadan, gerçeğe en yakın biçimde yeniden yapılanma ile karakterize olan yara iyileşmesi kırık iyileşmesidir. Kırık iyileşmesi; dayanıklılığı, oluşumu, yenilenmesi ve yapılanması çok sayıda genel ve yerel düzenleyicilere bağlı olan, hücresel yapıların karşılıklı etkileşimini içeren karmaşık bir süreçtir. Hematomenfl amasyon, yumuşak kallus, sert kallus ve yeniden şekillenme evrelerinden oluşur (Şekil-1). Bu süreç ve evreler şimdiye kadar iyi tanımlanmakla birlikte hala aydınlatılmayı bekleyen noktalar vardır. Diğer yandan kırık iyileşmesini olumlu ya da olumsuz etkileyen genel ve yerel etkenlerle ilgili birçok çalışma yapılmasına rağmen patofi zyolojisi ve etkileyen faktörlerin mekanizması hala tam aydınlatılamamıştır. Kırık iyileşme-sinde etkili faktörler, iyileşmenin uyarılması ve en iyi tedavi konusunda arayışlar devam etmektedir [1][2][3][4][5][6][7] . Kırık iyileșmesini etkileyen faktörlerKırık iyileşmesi üzerine olumlu ya da olumsuz etkisi olan genel ve yerel faktörler Tablo-1 de gösterilmiş-tir. Literatürde hem bu faktörlerle ilgili, hem de farklı enerji türleri ve elektromanyetik alan (EMA) uygulamaları gibi fi ziksel faktörlerin kırık iyileşmesi üzerine etkileriyle ilgili çeşitli biyolojik sistemlerde yapılmış çok

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Modification of fracture repair with selected pulsing electromagnetic fields.

Cited by 110 publications

References 0 publications

The effect of an intramedullary implant with a static magnetic field on the healing of the osteotomised rabbit femur

The effect of an intramedullary implant with a static magnetic field on the healing of the osteotomised rabbit femur

Effect of pulsed electromagnetic fields (PEMF) on late‐phase osteotomy gap healing in a canine tibial model

The effects of low and high frequency electromagnetic fields on fracture healing

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