Modification of experimental myocardial infarct size by cardiac drugs

Puri, Pritpal S.

doi:10.1016/0002-9149(74)90612-2

Cited by 36 publications

(7 citation statements)

References 30 publications

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“…Studies by Banka et al (4) and Puri (3) have reported that function returns rapidly after release of occluisions even up to 45 miil. The two miajor differences between those studies (3,4) and the present one are related to the preparation, i.e., conscious vs. anesthetized, and secondly, the techniques utilized for measurement of segment length. The difference is probably not due to effects of anesthesia inasmuch as a preliminary report by Weiner and coworkers (21) (5), but in that study the time-course of recovery for mechanical function was on the order of 2-5 min in contrast to the extended recovery periods of several hours observed in the present study.…”

Section: Discussionmentioning

confidence: 77%

“…It is currently held that coronary artery occlusions of 5-20-min duration do not result in permanent myocardial damage (1,2), and, in fact, that any derangement in function due to the ischemia is repaired quickly (3,4). This concept of rapid recovery is based primarily on studies in anesthetized animals with an open chest (3,4) or on pathological studies demonstrating no histologic evidence of cellular injury after occlusions of less than 18 min (2).…”

Section: Introductionmentioning

confidence: 99%

“…This concept of rapid recovery is based primarily on studies in anesthetized animals with an open chest (3,4) or on pathological studies demonstrating no histologic evidence of cellular injury after occlusions of less than 18 min (2). Furthermore, it is clear that electrocardiographic evidence of ischemia is abolished rapidly after brief periods of coronary occlusion in anesthetized (1,5,6) and conscious animals (7), but that these indices of ischemia do not provide information on the time-course of recovery for mechanical function of the myocardium.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

Heyndrickx¹,

Millard²,

McRitchie³

et al. 1975

J. Clin. Invest.

948

240

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A B S T R A C T The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. Total left ventricular (LV) function was assessed with measurements of LV systolic and diastolic pressures, rate of change of LV pressure (dP/dt), and dP/dt/P. Regional LV function was assessed with measurements of regional segment length and velocity of shortening. An implanted hydraulic occluder on either the left anterior descending or circumflex coronary artery was inflated for 5-and 15-min periods on separate days. A 5-min occlusion depressed overall LV function transiently, but just before release of occlusion overall function had nearlv returned to control. At this time regional function in the ischemic zone was still depressed to the point of absent shortening or paradoxical motion during systole and was associated with marked ST segment elevation (+ 10± 2.2 mV) at the sites where function was measured. With release of occlusion and reperfusion the intramyocardial electrogram returned to normal within 1 min, and reactive hyperemia subsided by 5-10 min. In contrast to the rapid return to preocclusion levels for coronary flow and the electrogram, regional mechanical function remained depressed for over 3 h. A 15-min coronary occlusion resulted in an even more prolonged (> 6 h)

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

Heyndrickx¹,

Millard²,

McRitchie³

et al. 1975

J. Clin. Invest.

948

240

View full text Add to dashboard Cite

show abstract

“…These interventions included postextrasystolic potentiation (21)(22)(23) and infusions of dopamine (24)(25)(26)(27) and isoproterenol (28)(29)(30)(31)(32) inserted into the left atrium for pressure monitoring. The LAD was carefully dissected free of the epicardium, and a balloon occluder device placed around its proximal portion.…”

mentioning

confidence: 99%

“…Infusions were intentionally limited to 2 min at each speed to avoid extreme elevations in heart rate and the secondary depression in myocardial performance known to occur in ischemic myocardium with longer infusion times (27)(28)(29)(30)(31)(32).…”

mentioning

confidence: 99%