Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis

Li, Na; Asan, Onur; Wu, Yuhuan; Luo, Xia; Chen, Zhengyuan; Sang, Chuanlan; Xiong, Tingting

doi:10.1016/j.biopha.2019.109044

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…This result was the same as that of Canani et al , 68 who found that Lactobacillus increased the abundance of butyric-producing bacteria. Li et al 69 pointed out that intestinal dysbacteriosis mice changed the TBA level, which was similar to our study. The results indicated that L. plantarum improved intestinal immunity by modulating the gut microbiota composition to increase SCFAs (acetic acid and butyric acid) and TBA, inhibiting inflammation and protecting the intestinal barrier.…”

Section: Discussionsupporting

confidence: 92%

Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice

et al. 2022

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Section: Discussionsupporting

confidence: 92%

Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice

et al. 2022

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“…Lieber et al (Lefevre et al., 1972) found for the first time that chronic alcohol consumption enlarged the bile acid pool and reduced the excretion of bile acid, which suggested that alcohol consumption could affect the enterohepatic circulation of bile acid. In addition, the signal of bile acid homeostasis can be sensed by the liver and intestine, which is the key to the homeostasis regulation of gut microflora (Li et al., 2019). In this study, alcohol exposure caused gut microflora and liver lipid metabolism disorder, leading to TG, TC, and TBA accumulation, probably caused by reduced excretion of fecal bile acids and increased intestinal reabsorption of bile acids.…”

Section: Discussionmentioning

confidence: 99%

Effect of nicotinamide riboside on lipid metabolism and gut microflora‐bile acid axis in alcohol‐exposed mice

Xue

Liu

et al. 2020

Food Science & Nutrition

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Alcoholic liver disease (ALD) is the most common complication of alcohol abuse, while we lack safe and effective treatment for ALD. This study aimed to explore the effects of nicotinamide riboside (NR) on lipid metabolism and gut microflora‐bile acid axis in alcohol‐exposed mice. NR significantly improved liver histopathological damage and abnormal liver function. NR as a provider of nicotinamide adenine dinucleotide (NAD+) increased the NAD+/NADH ratio. Meanwhile, NR inhibited the activation of the protein phosphatase 1 signaling pathway, decreased the liver triglyceride and total bile acid levels, and reduced lipid accumulation. According to the results of gut microflora species analysis, NR intervention changed the microbial community structure at the phylum, family and genus levels, and the species abundances returned to a level similar to these of the normal control group. Besides, the results of high‐performance liquid chromatograph‐mass spectrometry showed that NR intervention resulted in fecal bile acid levels tending to be normal with decreased chenodeoxycholic acid level and increased deoxycholic acid and hyocholic acid levels. Spearman's correlation analysis showed a correlation between gut microflora and bile acids. Therefore, NR supplementation has the potential to prevent ALD, and its mechanism may be related to regulating lipid metabolism disorders and the gut microflora‐bile acid axis.

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“…Traditional Chinese medicine (TCM) commonly used in feed additives can not only effectively treat various types of medical disorders but also maintain general health and prevent disease in animals ( Cao et al, 2015 ; Du et al, 2018 ; Li et al, 2019 ). Studies have shown that Codonopsis pilosula , as one of the traditional Chinese medicinal plants, has been used to effectively enhance immunity and improve microcirculation ( Fu et al, 2018 ), while another popular medicinal herbal plant Radix astragalus has shown pharmaceutical effects on immunomodulation and anti-oxidation activation ( Gong et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Mixture of Five Fermented Herbs (Zhihuasi Tk) Alters the Intestinal Microbiota and Promotes the Growth Performance in Piglets

Sun

Hong

et al. 2021

Front. Microbiol.

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To explore the feasibility of using fermented Chinese herbal mixture Zhihuasi Tk (Z. Tk) supplementation to increase the swine production, the protective effect of dietary supplementation with Z. Tk on the intestinal oxidative stress model and the regulation of both growth performance and intestinal microbiota of weaned piglets were investigated in vitro. Our results showed that the addition of Z. Tk increased the cell viability, prevented the decrease of glutathione peroxidase, and significantly increased the total antioxidant capacity and reduced the damage caused by H2O2 to the tight junction proteins of the porcine small intestinal epithelial cell line (IPEC-J2). Furthermore, weaned piglets supplemented with either 2 kg/ton zinc oxide (ZnO) or 4 kg/ton of Z. Tk in the diet increased body weight as well as average daily feed intake and daily gain, while the feed conversion rate and diarrhea rate decreased within 0–35 days. Results of the taxonomic structure of the intestinal microbiota showed that, in 21 days after weaning, the Firmicutes/Bacteroidetes ratio in experimental group was increased, while the abundance of beneficial bacteria such, as Lactobacillus, was increased by Z. Tk, showing inhibitory effect on pathogenic bacteria such as members of Proteobacteria. In summary, dietary supplementation with Z. Tk maintained the intestinal microbiota in a favorable state for the host to effectively reduce the abnormal changes in the intestinal microbial structure and improved growth performance of weaned piglets. Therefore, Z. Tk may potentially function as a substitute for ZnO in feed additives for weaned piglets in modern husbandry.

show abstract

Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis

Cited by 21 publications

References 42 publications

Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice

Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice

Effect of nicotinamide riboside on lipid metabolism and gut microflora‐bile acid axis in alcohol‐exposed mice

Mixture of Five Fermented Herbs (Zhihuasi Tk) Alters the Intestinal Microbiota and Promotes the Growth Performance in Piglets

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