Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Saario, I.; Linnoila, Markku; Mattila, Mikko

doi:10.1111/j.1365-2125.1976.tb00636.x

Cited by 18 publications

(8 citation statements)

References 16 publications

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“…The effects were similar to those obtained in healthy vol unteers . Similar results were also obtained by Linnoila and his group who, in two studies, found that diazepam in the same dose we used, impaired tracking and divided attention task performance in pa tients and volunteers alike [Saario et al, 1976;Linnoila et al. 1983], These results are reassuring to investigators in the field of behavioral effects of benzodiazepines as they confirm that results obtained in healthy volunteers can be applied to anxious patients.…”

Section: Discussionsupporting

confidence: 79%

Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Ghoneim¹,

Hinrichs²,

Noyes

et al. 1984

Neuropsychobiology

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The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover design. Both drugs impaired immediate free recall but the decrease was greater for diazepam than propranolol. Delayed free recall was also impaired but the two drugs did not differ. Paitents tapped faster after propranolol than diazepam and they were more sedated after diazepam than propranolol. After 2 weeks of treatment, patients tested 5–8 h after the last dose of medication did not show any decrement of performance. These results are similar to those previously found in healthy subjects. Accumulation of drugs was not reflected in prolonged behavioral impairment.

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Section: Discussionsupporting

confidence: 79%

Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Ghoneim¹,

Hinrichs²,

Noyes

et al. 1984

Neuropsychobiology

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“…However, the results obtained in healthy volunteers have previously been applicable to subacute (2 weeks) treatments of outpatients with anxiety (Saario et al 1976) and depression (Sepp~il/i et al 1978). Saario et al (1976) documented an impairment of psychomotor functions both with diazepam (15-30 mg daily) and with thioridazine (75-150 mg daily).…”

Section: Discussionmentioning

confidence: 99%

Objective and subjective assessments of the effects of flupentixol and benzodiazepines on human psychomotor performance

Mattila

Aranko

1988

Psychopharmacology

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The aim of this double-blind crossover trial was to compare the objective and subjective effects of flupentixol and lorazepam on human performance, and to reveal possible interactions between flupentixol and diazepam. Twelve healthy students received at 1-week intervals oral single doses of flupentixol 1 mg, flupentixol 2 mg, lorazepam 2.5 mg, placebo, and diazepam 15 mg alone and with flupentixol 1 mg. After the baseline measurements, the drugs were given in capsule form, and the tests were repeated 1.5, 3 and 4.5 h later. Diazepam was given at 1.5 h, to time its peak effect to coincide with that of lorazepam. Drug effects were measured objectively (two tracking tests, digit substitution, letter cancellation, flicker fusion, Maddox wing, tapping, memory) and subjectively (visual analogue scales, questionnaire). Blood samples were taken after each test time. Flupentixol 1 mg did not differ from placebo objectively or subjectively. Flupentixol 2 mg proved nearly inert objectively and on visual analogue scales. Lorazepam impaired objectively measured test performance, the clearest effects occurring at 3 and 4.5 h. It also impaired subjectively assessed performance. Diazepam impaired objective performance less than lorazepam, its effects peaking at 1.5 h after intake. Diazepam caused subjective drowsiness, clumsiness, mental slowness etc. as much as or more than lorazepam. The combination of 1 mg flupentixol and diazepam modified performance as much as diazepam alone. After the administration of 1 mg flupentixol, plasma concentrations were undetectable and levels after 2 mg were hardly detectable. Concentrations of lorazepam exceeded those of diazepam in direct bioassay, but they were much lower when bioassayed after solvent extraction.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Even 2 weeks' treatment with diazepam had no anxiolytic effects in terms of the patient-rated Morbid Anxiety Inventory (Bonn, Salkind & Linford Rees, 1971) and most studies could not detect anxiolytic effects in terms of psychiatrists' ratings after 1 week of treatment for example with nitrazepam (Malpas et al, 1974) and nordiazepam (Tansella et al, 1974). Definite clinical effects as evaluated by psychiatrists were found only after 2 weeks of treatment with clorazepate (Robin, Curry & Whelpton, 1974) and diazepam (Saario, Linnoila & Mattila, 1976;Dasberg, 1975). Because of the experimental design chosen for this study, and the high drop-out rate, a prolongation of each treatment for another week, requiring the patients to stay 2 months in hospital was impracticable.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the clinical and psychological effects of diazepam and amylobarbitone in anxious patients.

Tansella¹,

Tansella²,

Lader³

1979

Brit J Clinical Pharma

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1. Twenty-four anxious inpatients were treated with diazepam, amylobarbitone sodium and placebo in flexible dosage for 1 week. They each received all three treatments according to a fully-balanced design, using double-blind procedures. 2. The clinical and the psychological effects of the drugs were assessed by the comprehensive battery of psychiatrist's ratings, subjective and psychological tests before treatment and at the end of each week of treatment. The tests included self-rating of anxiolytic and hypnotic effects, reaction-time, card sorting, coding and cancellation tasks, arithmetic and tappin. 3. Diazepam improved significantly subjective anxiety and insomnia, while amylobarbitone improved only the self-rated quality of sleep. Occasion effects were absent on clinical measures, indicating that the patients did not respond to non-specific temporal factors. Performance on motor tasks improved over time because of the expected practice effect, but an impairment relative to placebo was detected on two motor tests after the barbiturate and on four other tests with a cognitive component after the benzodiazepine.

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Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Cited by 18 publications

References 16 publications

Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Objective and subjective assessments of the effects of flupentixol and benzodiazepines on human psychomotor performance

A comparison of the clinical and psychological effects of diazepam and amylobarbitone in anxious patients.

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