Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Ghoneim, Mohammed M.; Hinrichs, James V.; Noyes, Russell; Anderson, Dorothy J.

doi:10.1159/000118085

Cited by 13 publications

(2 citation statements)

References 28 publications

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“…Another study involving short-term chronic administration of diazepam failed to measure memory impairment several hours following the subject's previous dose (Ghoneim et al 1984a). A similar lack of correlation between the time course of memory impairment and the expected duration of plasma BZ levels has been noted in previous studies with drug-free subjects (Ghoneim et al 1984b;Kothary et al 1981 ;File and Bond 1979). We did not have the opportunity to determine whether the time course of memory impairment was altered by chronic BZ use.…”

Section: Discussionmentioning

confidence: 56%

Chronic use of benzodiazepines and psychomotor and cognitive test performance

1986

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The performance of 43 long-term users (average = 5 years) of benzodiazepine (BZ) medications was examined on a battery of behavioral tasks, cognitive tests, and subjective mood rating scales. The performance of the chronic BZ users did not differ significantly from age- and sex-matched anxious subjects, except that critical flicker fusion (CFF) thresholds were lower and subjective ratings of tranquilization were higher in the BZ users. Twenty-two subjects were reexamined in order to determine the acute effects of BZ medications in long-term users. The acute administration of BZ medications significantly increased CFF thresholds, improved digit-symbol substitution test performance, impaired the delayed recall of verbal material, increased subjective ratings of tranquilization, and reduced physical sedation. Motor performance tests were not impaired and subjective feelings of sedation were not increased after the acute administration of BZs by chronic users. During withdrawal from long-term BZ use (17 subjects), CFF thresholds were elevated, subjective ratings of physical sedation and anxiety were increased, but performance on other psychomotor and cognitive tests was not altered. The results suggest that tolerance develops selectively to different behavioral and subjective effects of BZ medications with their continued use. Tolerance failed to develop to the antianxiety effects, the reduction of CFF threshold, and to the impairment of short-term memory caused by BZs. However, chronic users of BZ medications failed to demonstrate psychomotor-impairing or sedating effects to BZ medications. The results have implications for evaluating the safety of the long-term use of BZ medications.

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Section: Discussionmentioning

confidence: 56%

Chronic use of benzodiazepines and psychomotor and cognitive test performance

1986

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“…Moreover, it has to be considered that some studies were performed in patients and others in healthy volunteers. For instance, Ghoneim et al (1984) found a deterioration in the free recall of a 24-word list after administration of propranolol (in doses from 80 to 320 mg) to patients with panic attacks and agoraphobia.…”

Section: Sleep Eegmentioning

confidence: 99%

Influence of cilazapril on memory functions and sleep behaviour in comparison with metoprolol and placebo in healthy subjects.

Dietrich¹,

Herrmann²

1989

Brit J Clinical Pharma

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1 In a controlled, randomized, double-blind study the influence of cilazapril and metoprolol on learning and memory functions and on sleep behaviour was investigated in healthy young volunteers under steady-state conditions. Twenty-three subjects were given either 2.5 mg cilazapril, 200 mg metoprolol, or placebo for 14 days in a latin square design separated by washout periods of 7 days. 2 To test memory functions different modalities-verbal, visual, numerical associative and two dimensional spatial memory were tested for recent anterograde recall, both shortterm (less than 10 s) and middle-term (up to 15 min) were selected. The test had a content similar to that used in daily life situations. The sleep behaviour was tested both by objective (all night sleep EEG) and subjective measures. 3 Neither antihypertensive drug had an observable influence on memory performance at the dosages used under steady-state conditions. However, sleep was disturbed during metoprolol, while cilazapril could not be differentiated from placebo. The effects of metoprolol on sleep behaviour were observed in the objective and subjective measures. There was more frequent awakening during the night with the subjective complaint of difficulties in sleeping through. 4 From this study it is concluded that cilazapril has no major effect on memory functions and sleep behaviour. This is only true for the dosages given and under steady-state conditions.

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Effects of anxiolytics on memory

Curran¹

1999

Hum. Psychopharmacol. Clin. Exp.

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Behavioral Effects of Diazepam and Propranolol in Patients with Panic Disorder and Agoraphobia

Cited by 13 publications

References 28 publications

Chronic use of benzodiazepines and psychomotor and cognitive test performance

Chronic use of benzodiazepines and psychomotor and cognitive test performance

Influence of cilazapril on memory functions and sleep behaviour in comparison with metoprolol and placebo in healthy subjects.

Effects of anxiolytics on memory

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