Modifiable Physical Factors Associated With Physical Functioning for Patients Receiving Dialysis: A Systematic Review

Tarca, Brett; Wycherley, Thomas P.; Bennett, Paul N.; Meade, Anthony; Ferrar, Katia

doi:10.1123/jpah.2019-0338

Cited by 11 publications

(16 citation statements)

References 78 publications

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“…In this study, we observed that there are far more men than women with COVID-19 in HD patients who are in line with the previous study on general population. This is due to the fact that the number of women in HD is lower than the men (13:18), and the women have sex hormones and X chromosome, which can regulate adaptive and innate immunity [7]. In addition, most HD patients infected with COVID-19 were mainly the elderly and those with other chronic diseases besides renal failure which is in line with the previous study, but the average age and odds of chronic disease were higher [7].…”

Section: Discussionsupporting

confidence: 84%

“…This is due to the fact that the number of women in HD is lower than the men (13:18), and the women have sex hormones and X chromosome, which can regulate adaptive and innate immunity [7]. In addition, most HD patients infected with COVID-19 were mainly the elderly and those with other chronic diseases besides renal failure which is in line with the previous study, but the average age and odds of chronic disease were higher [7]. This may be because the HD patients had older average age, more complications, and weaker immunity than the general population [6].…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study

Zhang

Cao²,

et al. 2020

Renal Failure

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Aim: Novel coronavirus pneumonia (COVID-19) has become pandemic. It brings serious threat to hemodialysis (HD) patients. Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19. Methods: We retrospectively analyzed the data of 31 HD patients with COVID-19. The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis. Results: 61.3% were severe, and 38.7% were mild. 83.9% had a close contact history with COVID-19 patients. The average age was 62.3 years comprising of 58.1% men and 41.9% women. Ninety percent had chronic diseases except ESRD. Clinical symptoms include cough (85%), fever (43%), and shortness of breath (48.4%), etc. Complications included ARDS (25.8%), AHF (22.6%), and septic shock (16.1%), etc. 64.5% of patients had remission, and 35.5% of patients had no remission with 6.5% deaths. Compared with the baseline before infection, HD patients with COVID-19 had lower lymphocytes, albumin and glucose, and higher D-dimer, albumin, phosphorus, lactate dehydrogenase, and CRP. There was no significant correlation between the neutrophils/lymphocytes ratio and the severity of the disease. Conclusions: Compared with the reported general population, the HD patients are susceptible to COVID-19 infection, especially older men and those with other underlying diseases. Moreover, HD patients have more severe infection and inflammation with less symptoms and worse outcome. COVID-19 infection can cause dialysis patients lower immunity, stronger inflammation, malnutrition, and internal environment disorder. Neutrophils/lymphocytes ratio does not reflect the severity of the HD patients with COVID-19.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study

Zhang

Cao²,

et al. 2020

Renal Failure

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“…Muscle function declines at a rate different from that of muscle size [ 24 ], and the worse physical function of patients on HD compared to non-CKD elderly was not explained by muscle size [ 22 ]. Nonetheless, a recent systematic review discusses how the association between physical function and muscle size in CKD patients is still controversial [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Silva

Antônio

Reis

et al. 2021

Kidney Res Clin Pract

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Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. Results: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 ± 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean ± standard deviation of handgrip strength was 24.7 ± 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. Conclusion: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients.

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“…The prevalence and severity of symptoms are associated with lower QoL [ 5 ]. Non-pharmacological strategies to improve QoL that consider patients’ symptoms are focused on some defined type of symptoms, either related to physical functioning (e.g., improving muscle strength through exercise) [ 9 ] or psycho-emotional (e.g., decreasing depressive and anxious symptoms through psychological interventions) [ 10 ]. Those interventions are effective for their therapeutic target [ 11 ] and involve some degree of active patient’s participation, but they often do not consider the patient’s perspective about their own ability to cope with multiple stressors inherent to their disease [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Differences in Self-Care, Treatment-Related Symptoms, and Quality of Life in Hemodialysis Patients

Lerma

Lima-Zapata

Aguilar

et al. 2021

IJERPH

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Gender and sex differences affect women with kidney failure (KF) negatively at all stages of the disease. This study assessed gender differences in self-care, hemodialysis symptoms, and quality of life in a sample of 102 adult KF patients treated with hemodialysis, from two clinical centers in Mexico. Self-care agency, quality of life, and the symptoms related to hemodialysis were evaluated through questionnaires, and sociodemographic and laboratory variables were obtained from the clinical records. Compared to male patients, female patients reported similar self-care, lower quality of life subscales (symptoms, physical functioning, pain, and overall health), and higher prevalence and intensity of hemodialysis symptoms. There were gender differences regarding the correlation between self-care and quality of life, symptoms intensity, and symptoms prevalence. In conclusion, women with KF treated with hemodialysis perceived a higher impact of hemodialysis and reported a lower quality of life than men. Despite having a similar self-care agency, the self-care correlations with quality of life and hemodialysis symptoms appeared different between men and women treated with chronic hemodialysis. Such differences may be important in future nursing interventions to improve self-care and quality of life among KF patients.

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Modifiable Physical Factors Associated With Physical Functioning for Patients Receiving Dialysis: A Systematic Review

Cited by 11 publications

References 78 publications

Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study

Clinical characteristics of 31 hemodialysis patients with 2019 novel coronavirus: a retrospective study

Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Gender-Specific Differences in Self-Care, Treatment-Related Symptoms, and Quality of Life in Hemodialysis Patients

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