Modifiable Midlife Risk Factors, Independent Aging, and Survival in Older Men: Report on Long‐Term Follow‐Up of the Uppsala Longitudinal Study of Adult Men Cohort

Franzon, Kristin; Zethelius, Björn; Cederholm, Tommy; Kilander, Lena

doi:10.1111/jgs.13352

Cited by 17 publications

(18 citation statements)

References 32 publications

(63 reference statements)

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“…ULSAM represents a longitudinal epidemiological, still ongoing, study based on all available men born 1920–1924 and who were living in Uppsala county in the beginning of the 1970s. These men had all undergone extensive examinations at approximately 50, 60, 70, 77, 82 and 88 years of age [ 21 , 22 ]. Full screening and official registry data are available in databases, which are being continuously updated ( http://www.pubcare.uu.se/ulsam ).…”

Section: Methodsmentioning

confidence: 99%

Cognitive function in very old men does not correlate to biomarkers of Alzheimer’s disease

Velickaite¹,

Giedraitis²,

Ström³

et al. 2017

BMC Geriatr

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BackgroundThe Alzheimer’s disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to relate cognitive performance to the degree of brain atrophy, CSF biomarker levels and neuropathology in a cohort of aged men.MethodsFifty-eight 86–92-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM) cohort underwent cognitive testing, brain computed tomography and lumbar puncture. Atrophy was graded with established scales. Concentrations of CSF Aβ42, t-tau and p-tau were measured by ELISA. Thirteen brains were examined post mortem.ResultsForty-six of the individuals were considered non-demented, whereas twelve were diagnosed with dementia, either at baseline (n = 4) or during follow-up (n = 8). When comparing subjects with and without dementia, there were no differences in the degree of atrophy, although the mini mental state examination (MMSE) scoring correlated weakly with the degree of medial temporal atrophy (MTA) (p = 0.04). Moreover, the CSF biomarker levels did not differ significantly between healthy (n = 27) and demented (n = 8) subjects (median values 715 vs 472 pg/ml for Aβ42, 414 vs 427 pg/ml for t-tau and 63 vs 60 pg/ml for p-tau). Similarly, there were no differences in the biomarker levels between individuals with mild (n = 24) and severe (n = 11) MTA (median values 643 vs 715 pg/ml for Aβ42, 441 vs 401 pg/ml for t-tau and 64 vs 53 pg/ml for p-tau). Finally, the neuropathological changes did not correlate with any of the other measures.ConclusionIn this cohort of aged men only a weak correlation could be seen between cognitive performance and MTA, whereas the various neuroradiological, biochemical and neuropathological measures did not correlate with each other. Thus, AD biomarkers seem to be less informative in subjects of an advanced age.

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Section: Methodsmentioning

confidence: 99%

Cognitive function in very old men does not correlate to biomarkers of Alzheimer’s disease

Velickaite¹,

Giedraitis²,

Ström³

et al. 2017

BMC Geriatr

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“…Several studies have suggested that midlife may be a crucial time window for the prevention of age‐related health decline . Several studies on the link between corpulence and either multidimensional healthy aging or longevity have been published. However, the commonly used main outcome has been survival , and only four studies have specifically targeted midlife as an exposure period .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies on the link between corpulence and either multidimensional healthy aging or longevity (13)(14)(15)(16)(17)(18)(19)31) have been published. However, the commonly used main outcome has been survival (13,14,18,19), and only four studies have specifically targeted midlife as an exposure period (13,15,17,18).…”

Section: Obesitymentioning

confidence: 99%

“…Current evidence indicates that individuals within the normal body mass index (BMI) range have the potential for better survival and health compared with individuals with overweight or obesity. Specifically, the available prospective observational studies suggest that elevated BMI or an increased body fat percentage plays a detrimental role with respect to healthy aging (13)(14)(15)(16)(17)(18)(19). However, studies that have investigated the relationship between anthropometric measures at midlife and healthy aging based on multidimensional concepts are scant (13,15,17).…”

Section: Introductionmentioning

confidence: 99%

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Prospective association between body mass index at midlife and healthy aging among French adults

Ruhunuhewa

Adjibade

Andreeva

et al. 2017

Obesity

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“…A Swedish study, Uppsala Longitudinal Study of Adult Men, which investigated men aged 49-51 years (n=2,293) in midlife and followed them up for four decades, showed that low work-time physical activity had a stronger association with better physical and cognitive function, but the association between leisure-time physical activity and olderage physical and cognitive function was not statistically significant (Franzon, Zethelius, Cederholm, & Kilander, 2015).…”

Section: Strong Evidence Supporting the Association Between Physicallmentioning

confidence: 99%

Untitled

Kulmala¹

2016

SIIW

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Physical activity earlier in life is considered one of the key determinants of an active and healthy older age. During the recent years, several population-based longitudinal studies with follow-up periods extending up to several decades have shown that a physically active lifestyle is associated with better older-age cognitive capacity and also decreased risk of dementia and Alzheimer's disease. Recent studies also show that increasing physical activity from mid-to late life have beneficial effects on later-life cognition, which indicates that the window of opportunity for preventive physical activity interventions may extend from midlife to old age. Among older people, the first randomized controlled trials aiming to prevent cognitive decline through physical activity and especially multidomain lifestyle-based interventions have been recently conducted, and promising results have been reported. This mini-review brings together information on life-long benefits of a physically active lifestyle, focusing on the favorable effects on brain health.

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Modifiable Midlife Risk Factors, Independent Aging, and Survival in Older Men: Report on Long‐Term Follow‐Up of the Uppsala Longitudinal Study of Adult Men Cohort

Abstract: A normal midlife BMI and not smoking were associated with independent aging close to four decades later, indicating that normal weight at midlife has the potential not only to increase survival, but also to preserve independence with aging.

Cited by 17 publications

References 32 publications

Cognitive function in very old men does not correlate to biomarkers of Alzheimer’s disease

Cognitive function in very old men does not correlate to biomarkers of Alzheimer’s disease

Prospective association between body mass index at midlife and healthy aging among French adults

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