Modes of Action of Taurine and Granulocyte Colony-stimulating Factor in Neuroprotection

Buddhala, Chandana; Prentice, Howard; Wu, Jang‐Yen

doi:10.1016/j.jecm.2011.11.001

Cited by 7 publications

(7 citation statements)

References 90 publications

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“…The mechanism by which G-CSF mediates the inhibition of neutrophil apoptosis requires further study. Although neutrophils from G-CSF knockout mice are not known to undergo accelerated apoptosis, it has been reported that G-CSF can inhibit apoptosis by increasing transcription of anti-apoptotic proteins ( 41 ). Our findings that G-CSF treated neutrophils display increased expression of BCL-xL and MCL-1 is in agreement with these reports, and suggests that the upregulation of these anti-apoptotic genes may contribute to the increased viability of neutrophils during infection.…”

Section: Discussionmentioning

confidence: 99%

The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection

et al. 2021

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Aspergillus fumigatus airway infections are associated with increased rates of hospitalizations and declining lung function in patients with chronic lung disease. While the pathogenesis of invasive A. fumigatus infections is well studied, little is known about the development and progression of airway infections. Previous studies have demonstrated a critical role for the IL-1 cytokines, IL-1α and IL-1β in enhancing pulmonary neutrophil recruitment during invasive aspergillosis. Here we use a mouse model of A. fumigatus airway infection to study the role of these IL-1 cytokines in immunocompetent mice. In the absence of IL-1 receptor signaling, mice exhibited reduced numbers of viable pulmonary neutrophils and increased levels of neutrophil apoptosis during fungal airway infection. Impaired neutrophil viability in these mice was associated with reduced pulmonary and systemic levels of G-CSF, and treatment with G-CSF restored both neutrophil viability and resistance to A. fumigatus airway infection. Taken together, these data demonstrate that IL-1 dependent G-CSF production plays a key role for host resistance to A. fumigatus airway infection through suppressing neutrophil apoptosis at the site of infection.

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Section: Discussionmentioning

confidence: 99%

The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection

et al. 2021

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“…Taurine has been shown to exert protective effects against neuronal damage by inhibiting the reverse mode Na + /Ca 2+ exchanger (Buddhala et al 2012 ) and by decreasing calcium in fl ux through L-, P/Q-, and N-type voltage-gated calcium channels as well as N -methyl-d -aspartic acid (NMDA) receptors (Wu et al 2005 ) .…”

Section: Discussionmentioning

confidence: 99%

Taurine Exerts Robust Protection Against Hypoxia and Oxygen/Glucose Deprivation in Human Neuroblastoma Cell Culture

Chen

Pan

Gharibani

et al. 2013

Advances in Experimental Medicine and Biology

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Stroke is one of the leading causes of mortality and disability worldwide. There is no effective treatment for stroke despite extensive research. Taurine is a free amino acid which is present at high concentrations in a range of organs including the brain, heart, and retina in mammalian systems. It had been shown that taurine can significantly increase cell survival under stroke conditions using both in vivo and in vitro models. Recently, we have found that several agents including granulocyte colony-stimulating factor (G-CSF), a stem cell enhancer and facilitator;S-methyl-N-diethylthiolcarbamate sulfoxide (DETC-MeSO), an NMDA receptor partial antagonist; sulindac, a potent antioxidant; and taurine, a neuroprotectant and calcium regulator, are effective in protecting against stroke-induced neuronal injury when used alone or in combination in both animal and tissue/cell culture models. In this chapter, we demonstrate that taurine can protect human neuroblastoma cells measured by ATP assay under conditions of hypoxia or oxygen/glucose deprivation (OGD). In addition, we found that taurine exerts its protective function by suppressing the OGD-induced upregulation of endoplasmic reticulum (ER) stress markers and proapoptotic proteins. A model depicting the mode of action of taurine in protecting neuroblastoma cells under OGD conditions is presented.

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“…Although laboratories should maintain the consistency of results, disproportionate delays in processing might affect the reliability of results (7). Taurine (2-aminoethanesulfonic acid -NH2CH2CH2SO3H), which is a naturallyoccurring ß-sulfonated amino acid, is one of the most abundant free amino acids in the human body (8); a 70 kg person can have up to 70 g of taurine (9). Taurine has been demonstrated to function as a direct or indirect antioxidant, inhibiting lipid peroxidation, and stabilizing bio-membrane structures and function by preventing any increase in membrane permeability due to the effect of oxidants, maintaining intracellular ion homeostasis, and inhibiting membrane protein phosphorylation (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Taurine (2-aminoethanesulfonic acid -NH2CH2CH2SO3H), which is a naturallyoccurring ß-sulfonated amino acid, is one of the most abundant free amino acids in the human body (8); a 70 kg person can have up to 70 g of taurine (9). Taurine has been demonstrated to function as a direct or indirect antioxidant, inhibiting lipid peroxidation, and stabilizing bio-membrane structures and function by preventing any increase in membrane permeability due to the effect of oxidants, maintaining intracellular ion homeostasis, and inhibiting membrane protein phosphorylation (8)(9)(10). Different studies have revealed the stability of whole blood samples when stored at a low temperature or when certain anticoagulants are used (2,5,11-13), however, to the best of our knowledge no published studies have investigated or considered the effect of antioxidants on the stability of CBC parameters.…”

Section: Introductionmentioning

confidence: 99%

Effect of the addition of the antioxidant taurine on the complete blood count of whole blood stored at room temperature and at 4°C for up to 3 days

2024

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Background: The complete blood count is one of the most common routine tests. This study aimed to evaluate possible effects of the antioxidant taurine on the complete blood count of whole blood stored at room temperature and at 4°C over three days.Methods: Venous blood samples of 15 healthy males were distributed into two sets of tubes with each set of three tubes containing 50 μL of solutions with zero, 5 g/L, 10 g/L taurine. The tubes were kept at room temperature or at 4°C. Complete blood counts were performed on three successive days. The mean percentage changes [Δ = (mean value – mean baseline value) / mean baseline value x 100] were calculated and compared.Results: Complete blood count parameters exhibited different patterns of behaviour which were affected by the storage temperature, time and taurine concentration. Taurine at room temperature significantly enhanced the stability of: the platelet count over three days (Δ3 at 5 and 10 g/L taurine were 6.18, and 2.53 x 109 cells/L, respectively); the red blood cell count over three days (Δ3 at 5 and 10 g/L taurine were 2.59, and 1.39 x 1012 cells/L, respectively); mean corpuscular haemoglobin over three days (Δ3 at 5 and 10 g/L taurine were,-0.62 and -0.52 fl respectively); and red cell distribution width over two days (Δ2 at 5 and 10 g/L taurine were 1.30% and -0.1%, respectively). No additional stabilizing effects of taurine were reported for the mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, haematocrit and haemoglobin, while it negatively affected the white blood cell stability.Conclusion: Complete blood count parameters exhibited variable stability patterns in respect to temperature, time and taurine concentration.

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Modes of Action of Taurine and Granulocyte Colony-stimulating Factor in Neuroprotection

Cited by 7 publications

References 90 publications

The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection

The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection

Taurine Exerts Robust Protection Against Hypoxia and Oxygen/Glucose Deprivation in Human Neuroblastoma Cell Culture

Effect of the addition of the antioxidant taurine on the complete blood count of whole blood stored at room temperature and at 4°C for up to 3 days

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