Modes of Action of Microbially-Produced Phytotoxins

Duke, Stephen O.; Dayan, Franck E.

doi:10.3390/toxins3081038

Cited by 108 publications

(77 citation statements)

References 169 publications

(174 reference statements)

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“…These symptoms are similar to herbicides that have a mechanism of action based on the inhibition of carotenoid biosynthesis. This mechanism of action is mainly characterized by depigmentation of the leaves caused by photobleaching of chlorophyll that occurs after blockage of the synthesis of carotenoid pigments (Duke and Dayan, 2011;Copping and Duke, 2007). …”

Section: Resultsmentioning

confidence: 99%

Optimization of solid-state fermentation for bioherbicide production by Phoma sp .

Klaic

Sallet

Foletto

et al. 2017

Braz. J. Chem. Eng.

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-In this work the bioherbicide production from Phoma sp. by solid-state fermentation was optimized. Agroindustrial residues such as bagasse, soybean bran and corn steep liquor were used as substrate. The bioherbicide was extracted from the fermented solid and the supernatant was applied for the control of the target plant. The evaluated responses in the bioassay were plant height, root length, fresh and dry weight, number of flowers and phytotoxicity. The results in the bioassays demonstrated that the bioherbicide presented activity towards the target plant and the intensity of the effect was influenced by the formulation of the fermentation medium. The optimized condition for bioherbicide production was (wt%): moisture content 70.0, soybean bran content 30.0 and corn steep liquor (CSL) 20.0, it being possible to obtain an injury phytotoxicity level of 40. The bioherbicide showed a mode of action based on the inhibition of carotenoid biosynthesis.

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Section: Resultsmentioning

confidence: 99%

Optimization of solid-state fermentation for bioherbicide production by Phoma sp .

Klaic

Sallet

Foletto

et al. 2017

Braz. J. Chem. Eng.

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“…In brain, CerS2 is expressed in oligodendrocytes but not in neurons 128 [27]. However, ceramide levels with distinct acyl chain lengths do not 129 always correlate with CerS expression [24,26,30]; thus, despite high 130 CerS2 expression in small intestine, C16-and C18-ceramides are the [49] (Fig. 1).…”

Section: Introductionmentioning

confidence: 98%

“…Inhibits amyloid beta-peptide biogenesis t4:12 AAL-toxin 0.035-0.04 [130,131] range. The first is FTY720, an FDA-approved drug for treatment of mul-535 tiple sclerosis [110], that upon its phosphorylation by sphingosine ki-536 nase, acts as an agonist of sphingosine 1-phosphate receptors [111].…”

mentioning

confidence: 99%

Ceramide synthases as potential targets for therapeutic intervention in human diseases

Park

Futerman

2014

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

200

176

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“…Microbes are good sources of diverse classes of natural products with many biological activities (Abdou et al 2009;Cutler 1995;Duke and Dayan 2011;Roemer et al 2011;Strobel et al 1991). Both endophytic fungi and pathogenic fungi use the host plant as a source for nutrients.…”

Section: Introductionmentioning

confidence: 99%

Phomalactone from a Phytopathogenic Fungus Infecting ZINNIA elegans (ASTERACEAE) Leaves

et al. 2015

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Zinnia elegans Jacq. plants are infected by a fungus that causes dark red spots with necrosis on leaves, particularly in late spring to the middle of summer in the Mid-South of the United States. This fungal disease causes the leaves to wilt and eventually kills the plant. The fungus was isolated, cultured in potato dextrose broth, and identified as Nigrospora sphaerica by molecular techniques. Two major lactone metabolites (phomalactone and catenioblin A) were isolated from liquid culture of N. sphaerica isolated from Z. elegans. When injected into leaves of Z. elegans, phomalactone caused lesions similar to those of the fungus. The lesion sizes were proportional to the concentration of the phomalactone. Phomalactone, but not catenioblin A, was phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons. This latter effect may be related to the wilting caused by the fungus in mature Z. elegans plants. Phomalactone was moderately fungicidal to Coletotrichum fragariae and two Phomopsis species, indicating that the compound may keep certain other fungi from encroaching into plant tissue that N. sphaerica has infected. Production of large amounts of phomalactone by N. sphaerica contributes to the pathogenic behavior of this fungus, and may have other ecological functions in the interaction of N. sphaerica with other fungi. This is the first report of isolation of catenioblin A from a plant pathogenic fungus. The function of catenioblin A is unclear, as it was neither significantly phyto- nor fungitoxic.

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Modes of Action of Microbially-Produced Phytotoxins

Cited by 108 publications

References 169 publications

Optimization of solid-state fermentation for bioherbicide production by Phoma sp .

Optimization of solid-state fermentation for bioherbicide production by Phoma sp .

Ceramide synthases as potential targets for therapeutic intervention in human diseases

Phomalactone from a Phytopathogenic Fungus Infecting ZINNIA elegans (ASTERACEAE) Leaves

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