Modern Plant Metabolomics for the Discovery and Characterization of Natural Products and Their Biosynthetic Genes

Kumar, Santosh; Sumner, Barbara W.; Sumner, Lloyd W.

doi:10.1016/b978-0-12-409547-2.14807-3

Cited by 3 publications

(2 citation statements)

References 340 publications

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“…Methyl eugenol and eugenol belong to the phenylpropanoids class of natural products, which are synthesized from primary metabolites, phenylalanine or tyrosine amino acids, via the shikimic acid pathway in plants [ 88 ]. They are common and major essential oil constituents of many Ocimum species, such as O. basilicum , O. campechianum , O. gratissimum , O. sanctum , and O. urticifolium [ 89 , 90 ].…”

Section: Discussionmentioning

confidence: 99%

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

Lim

Lee

et al. 2023

Insects

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Despite ongoing control efforts, the mosquito population and diseases vectored by them continue to thrive worldwide, causing major health concerns. There has been growing interest in the use of botanicals as alternatives to insecticides due to their widespread insecticidal properties, biodegradability, and adaptability to ecological conditions. In this study, we investigated the larvicidal activity and cytotoxicity effects of solvent extracts from three aromatic plants—Curcuma longa (turmeric), Ocimum americanum (hoary basil), and Petroselinum crispum (parsley)—against Aedes albopictus. Subsequently, we examined the phytochemical composition of the extracts through gas chromatography–mass spectrometry (GC–MS) analysis. Results revealed that the hexane extracts of O. americanum and P. crispum exhibited the greatest larvicidal activity with the lowest median lethal concentration (LC50) values (<30 µg/mL) at 24 h post-treatment, with the former found to be significantly less toxic towards African monkey kidney (Vero) cells. The GC–MS analysis of the said extract indicated the presence of different classes of metabolites, including phenylpropanoids, very long-chain alkanes, fatty acids and their derivatives, and terpenes, with the most abundant component being methyl eugenol (55.28%), most of which, have been documented for their larvicidal activities. These findings provide valuable insights into the potential use and development of bioinsecticides, particularly from O. americanum.

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Section: Discussionmentioning

confidence: 99%

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

Lim

Lee

et al. 2023

Insects

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“…Phenylpropanoids comprise a wide diverse group of secondary metabolites which are synthesized from the primary metabolites, phenylalanine or tyrosine amino acids, either through the shikimate or the phenylpropanoid pathway. Phenylpropanoids can be categorized into five different groups as Flavonoids, Lignans, Phenolic acids, Stilbenes, and Coumarins [ 174 ].…”

Section: Alternate Therapiesmentioning

confidence: 99%

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

Devi

Sarala

2021

Futur J Pharm Sci

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Background Influenza is an acute respiratory tract infection caused by the influenza virus. Vaccination and antiviral drugs are the two methods opted to control the disease. Besides their efficiency, they also cause adverse side effects. Hence, scientists turned their attention to powerful herbal medicines. This review put focus on various proven, scientifically validated anti-influenza compounds produced by the plants suggested for the production of newer drugs for the better treatment of influenza and its related antiviral diseases too. Main body In this review, fifty medicinal herb phytochemical constituents and their anti-influenza activities have been documented. Specifically, this review brings out the accurate and substantiates mechanisms of action of these constituents. This study categorizes the phytochemical constituents into primary and secondary metabolites which provide a source for synthesizing and developing new drugs. Conclusion This article provides a summary of the actions of the herbal constituents. Since the mechanisms of action of the components are elucidated, the pandemic situation arising due to influenza and similar antiviral diseases can be handled promisingly with greater efficiency. However, clinical trials are in great demand. The formulation of usage may be a single drug compound or multi-herbal combination. These, in turn, open up a new arena for the pharmaceutical industries to develop innovative drugs.

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Synthetic Biology of Plants-Derived Medicinal Natural Products

Nipunta,

Kaur,

Sagar

et al. 2024

Biosynthesis of Natural Products in Plants

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Modern Plant Metabolomics for the Discovery and Characterization of Natural Products and Their Biosynthetic Genes

Cited by 3 publications

References 340 publications

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

Synthetic Biology of Plants-Derived Medicinal Natural Products

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