Modern management of non-chemotherapy drug-induced agranulocytosis: a monocentric cohort study of 90 cases and review of the literature

Andrès, Emmanuel; Maloisel, Frédéric; Kurtz, Jean Emmanuel; Kaltenbach, Georges; Alt, M.; Weber, Jean Christophe; Sibilia, Jean; Schlienger, J. L.; Blicklé, J.F.; Jm, Brogard; Dufour, Patrick

doi:10.1016/s0953-6205(02)00085-7

Cited by 63 publications

(74 citation statements)

References 16 publications

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“…A monocentric study showed that antibiotics caused DIA in approximately 25% of the cases, with betalactams and trimethoprim-sulfamethoxazole being the most common rhabdomyolysis inducing antibiotics [33,34].…”

Section: Discussionmentioning

confidence: 99%

Iatrogenic AKI and Agranulocytosis: a Cautious Tale of Medication Use in Elderly Patients

Qin¹,

Cang²,

Liu³

et al. 2017

J Clin Exp Nephrol

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A 83-year-old female patient suffered from acute kidney injury a month after percutaneous coronary intervention. Two weeks before hospitalization, she experienced nausea and intermittent watery diarrhea. Laboratory test showed high levels of serum creatine kinase and lactate dehydrogenase, which were remarkably decreased after ceasing rosuvastatin and valsartan treatment. Despite the recovery of renal function, unfortunately one week later, she was diagnosed with agranulocytosis because of antibiotic therapy. When we stopped meropenem and switched to granulocyto-colony stimulating factor treatment, her white blood cell count returned to a normal range. In our case, both rhabdomyolysis and agranulocytosis were induced by drugs. We provided a literature review of the causes of acute kidney injury and the pathogenesis of rhabdomyolysis and agranulocytosis. We discussed how drugs might lead to these complications. This case highlights the need to be aware of the potential side effects of drugs, especially those given to elderly patients who are likely to be receiving several medications concurrently for managing chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Iatrogenic AKI and Agranulocytosis: a Cautious Tale of Medication Use in Elderly Patients

Qin¹,

Cang²,

Liu³

et al. 2017

J Clin Exp Nephrol

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“…Higa (9). Currently, this disorder remains a potential serious adverse event due to the frequency of severe sepsis and septic shock in approximately two-thirds of all hospitalized patients (2,10).…”

Section: Discussionmentioning

confidence: 99%

Azithromycin-Related Agranulocytosis in an Elderly Man with Acute Otitis Media

Kajiguchi

2009

Intern. Med.

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“…(Andres et al 2002). However, the data of Ibanez et al on community-acquired drug-induced agranulocytosis do not support that assumption (Ibanez et al 2005).…”

Section: Side Effectsmentioning

confidence: 92%

Thyroid Disorders

Gessl¹,

Lemmens‐Gruber²,

Kautzky‐Willer³

2012

Sex and Gender Differences in Pharmacology

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All forms of thyroid diseases are much more frequently observed in women than men, although the reasons are still not completely elucidated.Hyperthyroidism is defined by elevated circulating free thyroid hormones. The prevalence is about 2 % in women and 0.2 % in men. The most frequent causes are various forms of thyroid autonomy in elderly women and Graves' disease, which occurs mostly in younger women.Hypothyroidism is defined by a lack of thyroid hormones. It is a common endocrine disorder caused by autoimmune thyroiditis (Hashimoto thyroiditis), iodine deficiency or following surgery or radioiodine therapy. Thyroxine requirements depend on fat-free mass and are, therefore, somewhat higher in males who are more often undersubstituted. In pregnancy lower TSH-reference ranges have to be considered and thyroid function should be monitored throughout pregnancy to avoid harm to the foetus caused by maternal thyroid dysfunctions. If overtreated women more often feature fractures, whereas males more often develop atrial fibrillation.

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Modern management of non-chemotherapy drug-induced agranulocytosis: a monocentric cohort study of 90 cases and review of the literature

Cited by 63 publications

References 16 publications

Iatrogenic AKI and Agranulocytosis: a Cautious Tale of Medication Use in Elderly Patients

Iatrogenic AKI and Agranulocytosis: a Cautious Tale of Medication Use in Elderly Patients

Azithromycin-Related Agranulocytosis in an Elderly Man with Acute Otitis Media

Thyroid Disorders

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