Modern encroachment in synthetic approaches to access nifty quinoline heterocycles

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

“…[64] Amongst all the tested compounds, 3-(6-(2,5-dimethoxy phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-5-bromo-1Hindole exhibited promising anticancer action against the sixty human cancer lines, with IC 50 value of between 1.67 μM and 10.3 μM.Sagar et al [65] took the improvement of indole and Cglycosides previously known for various biological potential and structural motifs in numerous natural products. The author disclosed the synthesis and antitumor activity of a new series of pyrazoline and isoxazole bridged indoles C-glycoside hybrids (25). The anticancer activity evaluation of new indole hybrids was tested against MCF-7, MDA-MB-453, and MDA-MB-231 cancer cell lines and some of the tested derivatives exhibit more effective cytotoxic effects with IC 50 values 0.67-4.67 μM.…”

“…Mani et al recent review [16] summarized the available indole-derived AhR ligands includes information on natural and dietary substances, synthetic substances, including drugs utilized in clinical study, endogenous intermediary metabolites, and catabolites produced by human microbiota. In light of the aforementioned findings and as part of our ongoing research, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] it is suggested that the current review provide a general overview of the various research initiatives taking place in this expanding field. Additionally, the review's notch provides information on recent investigations of biologically requisite indole derivatives.…”

Design, Synthesis, Spectral analysis, Drug likeness prediction, and molecular docking investigations of new naphtho[2,1-b]furan encompassing pyrimidines as potential antimicrobial agents

“…Several furan and pyrimidine derived drugs are accessible in the market , in continuation of our research interest on synthesis and biological activities of heterocycles [21][22][23][24][25][26][27][28] and which were encourage our interest to investigate a series of N-(4chlorophenyl)naphtho [1',2':4,5]furo [3,2-d]pyrimidin-8-amines 5(a-l) compounds and examine their binding interaction with microorganisms by the molecular docking method. To categorize possible drug candidates, the newly synthesized compounds were tested for their antimicrobial activity.…”